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View Structure Prediction Details

Protein: TPN1
Organism: Saccharomyces cerevisiae
Length: 579 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TPN1.

Description E-value Query
Range
Subject
Range
gi|151943630 - gi|151943630|gb|EDN61940.1| pyridoxine transporter [Saccharomyces cerevisiae YJM789]
TPN1_YEAST - Vitamin B6 transporter TPN1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TPN1 PE=1 SV...
TPN1 - Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamil...
gi|207345489 - gi|207345489|gb|EDZ72297.1| YGL186Cp-like protein [Saccharomyces cerevisiae AWRI1631]
0.0 [1..579] [1..579]
gi|10303307 - gi|10303307|emb|CAC10063.1| purine-cytosine permease, putative [Kluyveromyces marxianus]
0.0 [3..579] [7..561]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [15..579] [27..528]
gi|447739 - gi|447739|prf||1915304A nylB upstream ORF
1.0E-97 [12..532] [38..581]

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Predicted Domain #1
Region A:
Residues: [1-68]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNRDNMDTTK RKEDHTKHTT DVIEFYEEGT AASSLNIATE KANSSPSILR RIINRAAWLS  60
   61 KKVDAMGV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.409 a.4.1 Homeodomain-like
View Download 0.512 a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.630 a.50.1 Anaphylotoxins (complement system)
View Download 0.481 a.118.11 Cytochrome c oxidase subunit E
View Download 0.438 d.54.1 Enolase N-terminal domain-like
View Download 0.387 a.4.1 Homeodomain-like
View Download 0.386 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.370 a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.359 a.60.3 C-terminal domain of RNA polymerase alpha subunit
View Download 0.359 a.4.5 "Winged helix" DNA-binding domain
View Download 0.351 a.4.5 "Winged helix" DNA-binding domain
View Download 0.312 a.4.1 Homeodomain-like
View Download 0.305 a.4.5 "Winged helix" DNA-binding domain
View Download 0.303 a.118.8 TPR-like
View Download 0.303 a.4.5 "Winged helix" DNA-binding domain
View Download 0.289 a.36.1 Signal peptide-binding domain
View Download 0.285 a.64.1 Saposin
View Download 0.279 a.23.5 Hemolysin expression modulating protein HHA
View Download 0.277 a.60.5 Barrier-to-autointegration factor, BAF
View Download 0.277 a.60.1 SAM/Pointed domain
View Download 0.259 a.4.1 Homeodomain-like
View Download 0.257 a.4.1 Homeodomain-like
View Download 0.257 a.4.13 Sigma3 and sigma4 domains of RNA polymerase sigma factors
View Download 0.254 c.13.2 Anti-sigma factor antagonist SpoIIaa
View Download 0.250 a.4.1 Homeodomain-like
View Download 0.248 a.4.1 Homeodomain-like
View Download 0.248 a.159.1 Protein serine/threonine phosphatase 2C, C-terminal domain
View Download 0.246 a.4.8 Ribosomal protein S18
View Download 0.240 a.60.2 RuvA domain 2-like
View Download 0.235 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.222 a.4.11 RNA polymerase subunit RPB10
View Download 0.219 a.65.1 Annexin
View Download 0.217 a.181.1 Antibiotic binding domain of TipA-like multidrug resistance regulators
View Download 0.203 a.74.1 Cyclin-like
View Download 0.202 a.85.1 Hemocyanin, N-terminal domain

Predicted Domain #2
Region A:
Residues: [69-579]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ESTGIQRISP YERGTSKKQF LHVAGLWLSA TGGLSSMSSF LLGPLLFGLS FRESVASSLI  60
   61 SVTIGCLIAA YCSIMGPQSG CRQMVTARYL FGWWFVKLVA LASIIGVMGW SVVNSVVGGE 120
  121 MLAAISNDKV PLWVGIVIVT VCSFLVAIFG IKQVIKVETY LSVPVLTAFL LLYISSSDKY 180
  181 SFVNAYVSKG NLDSSTRKGN WMSFFSLCYS ITATWGSITA DYYILFPEDT PYIQIFCLTF 240
  241 FGTFLPTCFV GILGLLLASV AMSYKPWSVE YDSHGMGGLL WAGFQRWNGF GKFCVVVLVF 300
  301 SLVSNNIINT YSAAFSIQLS SVFCAKIPRW FWSIVCTIIC LVCALIGRNH FSTILGNFLP 360
  361 MIGYWISMYF ILLFEENLVF RRFFLHLYTK EFPTVTGEIN GPELVGSSKE VEKDAVTNIH 420
  421 LLKRKHKVTK HRYNWDKWED YEVLTHGYAA TFAFIVGVAG VVVGMAQAYW IGPIAAKFGE 480
  481 YGGDVAMWLS MAFSGVVYPP CRYLELRKFG R

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 4.136677
Match: PF02133
Description: Permease for cytosine/purines, uracil, thiamine, allantoin

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [502-579]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NWDKWEDYEV LTHGYAATFA FIVGVAGVVV GMAQAYWIGP IAAKFGEYGG DVAMWLSMAF  60
   61 SGVVYPPCRY LELRKFGR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


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