YRC Public Data Repository - Protein Structure Prediction

Protein:	CUP2
Organism:	Saccharomyces cerevisiae
Length:	225 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CUP2.

Description	E-value	Query Range	Subject Range
CUP2_YEAST - Transcriptional activator protein CUP2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=C... CUP2 - Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and...	8.0E-95	[1..225]	[1..225]
AMT1_CANGA - Metal-activated transcriptional activator protein AMT1 OS=Candida glabrata GN=AMT1 PE=1 SV=1 AMT1_CANGA - Metal-activated transcriptional activator protein AMT1 OS=Candida glabrata (strain ATCC 2001 / CBS 1...	5.0E-77	[1..224]	[1..245]
CRF1_YARLI - Copper resistance protein CRF1 OS=Yarrowia lipolytica GN=CRF1 PE=4 SV=1 CRF1_YARLI - Copper resistance protein CRF1 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=CRF1 PE=3 SV=1	2.0E-30	[1..127]	[1..110]
cuf1 - Cu metalloregulatory transcription factor Cuf1 CUF1_SCHPO - Metal-binding regulatory protein cuf1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=cuf1...	4.0E-22	[1..68]	[1..66]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	6.0E-19	[1..85]	[1..72]

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Predicted Domain #1

Region A:
Residues: [1-75]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVVINGVKYA CETCIRGHRA AQCTHTDGPL QMIRRKGRPS TTCGHCKELR RTKNFNPSGG  60
   61 CMCASARRPA VGSKE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	115.24799
Match:	1co4A_
Description:	Zinc domain conserved in yeast copper-regulated transcription factors
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [76-225]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DETRCRCDEG EPCKCHTKRK SSRKSKGGSC HRRANDEAAH VNGLGIADLD VLLGLNGRSS  60
   61 DVDMTTTLPS LKPPLQNGEI KADSIDNLDL ASLDPLEQSP SISMEPVSIN ETGSAYTTTN 120
  121 TALNDIDIPF SINELNELYK QVSSHNSHSQ

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits