YRC Public Data Repository - Protein Structure Prediction

Protein:	PEX14
Organism:	Saccharomyces cerevisiae
Length:	341 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PEX14.

Description	E-value	Query Range	Subject Range
gi\|190407097 - gi\|190407097\|gb\|EDV10364.1\| peroxisomal membrane protein PEX14 [Saccharomyces cerevisiae RM11-1a] PEX14_YEAST - Peroxisomal membrane protein PEX14 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PEX14... PEX14 - Peroxisomal membrane peroxin that is a central component of the peroxisomal protein import machinery... gi\|151943660 - gi\|151943660\|gb\|EDN61970.1\| peroxin [Saccharomyces cerevisiae YJM789]	2.0E-85	[1..341]	[1..341]
gi\|85085658 - gi\|85085658\|ref\|XP_957540.1\| hypothetical protein NCU03901 [Neurospora crassa OR74A] gi\|32405214, gi\|... - gi\|32405214\|ref\|XP_323220.1\| hypothetical protein [Neurospora crassa], gi\|28918633\|gb\|EAA28304.1\| co...	1.0E-65	[8..327]	[3..343]
PEX14_MOUSE - Peroxisomal membrane protein PEX14 OS=Mus musculus GN=Pex14 PE=1 SV=1	7.0E-62	[9..303]	[25..288]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	1.0E-61	[8..327]	[3..347]
gi\|4126962, gi\|2... - gi\|4126962\|dbj\|BAA36835.1\| peroxisomal membrane anchor protein [Rattus norvegicus], gi\|25453374\|ref\|...	7.0E-60	[9..303]	[25..288]
PEX14_CRILO - Peroxisomal membrane protein PEX14 OS=Cricetulus longicaudatus GN=PEX14 PE=2 SV=1	1.0E-58	[9..303]	[25..288]
PEX14 - peroxisomal biogenesis factor 14 gi\|114553893 - gi\|114553893\|ref\|XP_001162201.1\| PREDICTED: similar to peroxisomal membrane anchor protein HsPex14p ... gi\|123984941, gi... - gi\|60821767\|gb\|AAX36586.1\| peroxisomal biogenesis factor 14 [synthetic construct], gi\|123998459\|gb\|A...	5.0E-58	[9..302]	[25..287]
PEX14_PICAN - Peroxisomal membrane protein PER10 OS=Pichia angusta GN=PEX14 PE=3 SV=1 PEX14_PICAN, PEX... - (P78723) Peroxisomal membrane protein PER10 (Peroxin-14), Peroxisomal membrane protein PER10 OS=Pich...	8.0E-53	[9..318]	[10..318]
PEX14_PICPA - Peroxisomal membrane protein PEX14 OS=Komagataella pastoris GN=PEX14 PE=1 SV=1 jgi\|Picpa1\|40303... - null gi\|238034041, gi... - gi\|254574266\|ref\|XP_002494242.1\| Peroxisomal membrane peroxin that is a central component of the per...	5.0E-50	[5..309]	[1..356]
PEX14_SCHPO - Peroxisomal membrane protein pex14 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=pex14 P... pex14 - peroxisomal membrane anchor protein	7.0E-48	[9..272]	[2..245]

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Predicted Domain #1

Region A:
Residues: [1-124]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDVVSKDRK ALFDSAVSFL KDESIKDAPL LKKIEFLKSK GLTEKEIEIA MKEPKKDGIV  60
   61 GDEVSKKIGS TENRASQDMY LYEAMPPTLP HRDWKDYFVM ATATAGLLYG AYEVTRRYVI 120
  121 PNIL

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.263	0.524	protein binding, bridging	c.2.1	NAD(P)-binding Rossmann-fold domains
View	Download	0.263	0.523	peroxisomal membrane	c.2.1	NAD(P)-binding Rossmann-fold domains
View	Download	0.268	0.250	protein binding, bridging	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.268	0.250	peroxisomal membrane	a.4.5	"Winged helix" DNA-binding domain
View	Download	0.280	0.021	protein binding, bridging	a.156.1	S13-like H2TH domain
View	Download	0.280	0.021	peroxisomal membrane	a.156.1	S13-like H2TH domain
View	Download	0.209	0.018	protein binding, bridging	a.73.1	Retrovirus capsid protein, N-terminal core domain
View	Download	0.221	0.006	peroxisomal membrane	a.4.3	ARID-like
View	Download	0.232	N/A	N/A	a.156.1	S13-like H2TH domain
View	Download	0.209	N/A	N/A	a.73.1	Retrovirus capsid protein, N-terminal core domain

Predicted Domain #2

Region A:
Residues: [125-253]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PEAKSKLEGD KKEIDDQFSK IDTVLNAIEA EQAEFRKKES ETLKELSDTI AELKQALVQT  60
   61 TRSREKIEDE FRIVKLEVVN MQNTIDKFVS DNDGMQELNN IQKEMESLKS LMNNRMESGN 120
  121 AQDNRLFSI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	18.30103
Match:	1i84S_
Description:	Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [254-341]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPNGIPGIDT IPSASEILAK MGMQEESDKE KENGSDANKD DNAVPAWKKA REQTIDSNAS  60
   61 IPEWQKNTAA NEISVPDWQN GQVEDSIP

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.218	a.64.1	Saposin
View	Download	0.298	a.134.1	Fungal elicitin

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits