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View Structure Prediction Details

Protein: MAD1
Organism: Saccharomyces cerevisiae
Length: 749 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MAD1.

Description E-value Query
Range		 Subject
Range
MYH4_PIG - Myosin-4 OS=Sus scrofa GN=MYH4 PE=2 SV=1
 3.0E-88 [1..746] [911..1628]
gi|45383668, gi|... - gi|9800486|gb|AAF99314.1|AF272033_1 fast myosin heavy chain isoform 2 [Gallus gallus], gi|45383668|r...
 9.0E-87 [1..746] [917..1634]
MYH4_RABIT - Myosin-4 OS=Oryctolagus cuniculus GN=MYH4 PE=1 SV=1
 1.0E-86 [1..746] [912..1629]
MYH2_BOVIN - Myosin-2 OS=Bos taurus GN=MYH2 PE=2 SV=1
 1.0E-86 [1..746] [914..1631]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 2.0E-86 [1..746] [911..1628]
MYH1 - myosin, heavy chain 1, skeletal muscle, adult
 2.0E-86 [1..746] [913..1630]

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Predicted Domain #1
Region A:
Residues: [1-275] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDVRAALQCF FSALSGRFTG KKLGLEIYSI QYKMSNSGGS SPFLESPGGS PDVGSTNGQS  60
   61 NRQIQALQFK LNTLQNEYEI EKLQLQKQTN ILEKKYKATI DELEKALNDT KYLYESNDKL 120
  121 EQELKSLKER SANSMNDKDK CIEELRTTLQ NKDLEMETLR QQYDSKLSKV TNQCDHFKLE 180
  181 AESSHSLLMK YEKEIKRQSV DIKDLQHQVM EKDDELSSVK ASKMINSHPN YSTEEFNELT 240
  241 EMNKMIQDQV QYTKELELAN MQQANELKKL KQSQD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.154902
Match: 1i84S_
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [276-364] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TSTFWKLENE KLQNKLSQLH VLESQYENLQ LENIDLKSKL TKWEIYNDSD DDDDNNVNNN  60
   61 DNNNNNKNDN NNDNNNDTSN NNNINNNNR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.69897
Match: 2tmaA_
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [365-446] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TKNNIRNNPE EIIRDWKLTK KECLILTDMN DKLRLDNNNL KLLNDEMALE RNQILDLNKN  60
   61 YENNIVNLKR LNHELEQQKS LS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.69897
Match: 2tmaA_
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [447-508] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FEECRLLREQ LDGLYSAQNN ALLEVENSET HASNKNVNED MNNLIDTYKN KTEDLTNELK  60
   61 KL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.69897
Match: 2tmaA_
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [509-619] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NDQLLSNSND VETQRKKRKL TSDQIGLNYS QRLNELQLEN VSVSRELSKA QTTIQLLQEK  60
   61 LEKLTKLKEK KIRILQLRDG PFIKDQFIKK NKLLLLEKEN ADLLNELKKN N

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.69897
Match: 2tmaA_
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [620-749] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PAVETVPISV YDSLNFELKQ FEQEVFKSNK RFSRLKQVFN NKSLEFIDVV NSLLGFKLEF  60
   61 QQDSRVKIFS CFKPEKYLIA DLNENTLKSN LDADIEGWDD LMNLWVEDRG QLPCFLATIT 120
  121 LRLWEQRQAK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.837 0.313 nuclear pore a.25.1 Ferritin-like
View Download 0.807 N/A N/A a.25.1 Ferritin-like
View Download 0.663 N/A N/A f.14.1 Voltage-gated potassium channels
View Download 0.632 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.611 N/A N/A a.3.1 Cytochrome c
View Download 0.606 N/A N/A d.129.1 TATA-box binding protein-like
View Download 0.600 N/A N/A a.69.1 C-terminal domain of alpha and beta subunits of F1 ATP synthase
View Download 0.596 N/A N/A f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.558 N/A N/A a.47.2 t-snare proteins
View Download 0.531 N/A N/A a.1.1 Globin-like
View Download 0.529 N/A N/A a.25.2 Thermoplasma ferritin-like 4-helical bundle
View Download 0.509 N/A N/A a.24.3 Cytochromes
View Download 0.488 N/A N/A i.11.1 Computational models partly based on NMR data
View Download 0.488 N/A N/A a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.483 N/A N/A a.70.1 N-terminal domain of the delta subunit of the F1F0-ATP synthase
View Download 0.478 N/A N/A f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.475 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.469 N/A N/A c.23.12 Formate/glycerate dehydrogenase catalytic domain-like
View Download 0.451 N/A N/A a.47.2 t-snare proteins
View Download 0.442 N/A N/A a.24.4 Hemerythrin
View Download 0.435 N/A N/A f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.427 N/A N/A a.24.9 alpha-catenin/vinculin
View Download 0.423 N/A N/A a.25.2 Thermoplasma ferritin-like 4-helical bundle
View Download 0.420 N/A N/A a.24.16 Nucleotidyltransferase substrate binding subunit/domain
View Download 0.413 N/A N/A a.24.16 Nucleotidyltransferase substrate binding subunit/domain
View Download 0.412 N/A N/A a.7.5 Tubulin chaperone cofactor A
View Download 0.408 N/A N/A i.11.1 Computational models partly based on NMR data
View Download 0.400 N/A N/A a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.390 N/A N/A b.34.9 Tudor/PWWP/MBT
View Download 0.382 N/A N/A a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.380 N/A N/A c.53.1 Resolvase-like
View Download 0.379 N/A N/A a.24.9 alpha-catenin/vinculin
View Download 0.378 N/A N/A f.21.2 Fumarate reductase respiratory complex transmembrane subunits
View Download 0.377 N/A N/A a.25.2 Thermoplasma ferritin-like 4-helical bundle
View Download 0.373 N/A N/A a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.369 N/A N/A a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.359 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.356 N/A N/A a.24.9 alpha-catenin/vinculin
View Download 0.354 N/A N/A a.24.9 alpha-catenin/vinculin
View Download 0.346 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.345 N/A N/A f.18.1 F1F0 ATP synthase subunit A
View Download 0.336 N/A N/A a.29.3 Acyl-CoA dehydrogenase C-terminal domain-like
View Download 0.335 N/A N/A a.118.8 TPR-like
View Download 0.329 N/A N/A d.224.1 SufE-like
View Download 0.327 N/A N/A c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.321 N/A N/A a.170.1 BRCA2 helical domain
View Download 0.320 N/A N/A a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain
View Download 0.319 N/A N/A a.24.4 Hemerythrin
View Download 0.317 N/A N/A a.47.2 t-snare proteins
View Download 0.311 N/A N/A a.7.7 BAG domain
View Download 0.305 N/A N/A d.110.4 SNARE-like
View Download 0.299 N/A N/A f.18.1 F1F0 ATP synthase subunit A
View Download 0.298 N/A N/A f.21.2 Fumarate reductase respiratory complex transmembrane subunits
View Download 0.291 N/A N/A d.134.1 Sulfite reductase hemoprotein (SiRHP), domains 2 and 4
View Download 0.290 N/A N/A a.25.1 Ferritin-like
View Download 0.286 N/A N/A a.24.9 alpha-catenin/vinculin
View Download 0.280 N/A N/A a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.280 N/A N/A a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.278 N/A N/A a.63.1 Apolipophorin-III
View Download 0.274 N/A N/A a.7.6 Ribosomal protein S20
View Download 0.269 N/A N/A f.21.2 Fumarate reductase respiratory complex transmembrane subunits
View Download 0.268 N/A N/A a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.268 N/A N/A a.126.1 Serum albumin-like
View Download 0.259 N/A N/A a.7.1 Spectrin repeat
View Download 0.258 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.257 N/A N/A a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.256 N/A N/A a.7.1 Spectrin repeat
View Download 0.250 N/A N/A a.126.1 Serum albumin-like
View Download 0.248 N/A N/A a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.247 N/A N/A a.29.3 Acyl-CoA dehydrogenase C-terminal domain-like
View Download 0.246 N/A N/A a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.243 N/A N/A a.25.1 Ferritin-like
View Download 0.241 N/A N/A a.25.2 Thermoplasma ferritin-like 4-helical bundle
View Download 0.241 N/A N/A a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.241 N/A N/A a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.237 N/A N/A a.39.1 EF-hand
View Download 0.233 N/A N/A a.126.1 Serum albumin-like
View Download 0.228 N/A N/A a.40.1 Calponin-homology domain, CH-domain
View Download 0.226 N/A N/A a.73.1 Retrovirus capsid protein, N-terminal core domain
View Download 0.223 N/A N/A d.19.1 MHC antigen-recognition domain
View Download 0.220 N/A N/A c.44.2 Enzyme IIB-cellobiose
View Download 0.219 N/A N/A a.63.1 Apolipophorin-III
View Download 0.219 N/A N/A d.95.2 Homing endonucleases
View Download 0.217 N/A N/A a.7.7 BAG domain
View Download 0.217 N/A N/A d.14.1 Ribosomal protein S5 domain 2-like
View Download 0.216 N/A N/A a.7.7 BAG domain
View Download 0.215 N/A N/A a.7.7 BAG domain
View Download 0.215 N/A N/A a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.214 N/A N/A a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.213 N/A N/A a.126.1 Serum albumin-like
View Download 0.209 N/A N/A e.34.1 NSP3 homodimer
View Download 0.208 N/A N/A a.39.1 EF-hand
View Download 0.206 N/A N/A a.3.1 Cytochrome c
View Download 0.205 N/A N/A d.108.1 Acyl-CoA N-acyltransferases (Nat)
View Download 0.204 N/A N/A a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.204 N/A N/A a.71.2 Helical domain of Sec23/24
View Download 0.203 N/A N/A a.118.8 TPR-like
View Download 0.202 N/A N/A a.7.5 Tubulin chaperone cofactor A
View Download 0.202 N/A N/A a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle