YRC Public Data Repository - Protein Structure Prediction

Protein:	LCL3
Organism:	Saccharomyces cerevisiae
Length:	274 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LCL3.

Description	E-value	Query Range	Subject Range
LCL3_YEAST - Probable endonuclease LCL3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=LCL3 PE=1 SV=... LCL3_YEAS1 - Probable endonuclease LCL3 OS=Saccharomyces cerevisiae (strain RM11-1a) GN=LCL3 PE=3 SV=1 LCL3 - Putative protein of unknown function, has homology to Staphylococcus aureus nuclease; green fluoresc... LCL3_YEAS2 - Probable endonuclease LCL3 OS=Saccharomyces cerevisiae (strain JAY291) GN=LCL3 PE=3 SV=1 LCL3_YEAS7 - Probable endonuclease LCL3 OS=Saccharomyces cerevisiae (strain YJM789) GN=LCL3 PE=3 SV=1	2.0E-83	[1..274]	[1..274]
Y38K_CAPSE - Uncharacterized 38.1 kDa protein OS=Capnoides sempervirens PE=2 SV=1	2.0E-51	[50..273]	[141..333]
CAN1_ARATH - Staphylococcal-like nuclease CAN1 OS=Arabidopsis thaliana GN=CAN1 PE=1 SV=1	6.0E-49	[50..273]	[127..318]
gi\|14030876 - gi\|14030876\|gb\|AAK52082.1\| nuclease [Nicotiana tabacum]	1.0E-47	[50..273]	[132..323]
CAN1_ORYSJ - Probable staphylococcal-like nuclease CAN1 OS=Oryza sativa subsp. japonica GN=Os01g0166100 PE=2 SV=1	6.0E-45	[50..272]	[133..324]
LCL3_SCHPO - Probable endonuclease C19F8.04c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPBC19F8.0... SPBC19F8.04c - nuclease	1.0E-41	[18..274]	[10..230]
gi\|9507655, gi\|5... - gi\|9507655\|ref\|NP_052986.1\| hypothetical protein R100p106 [Plasmid R100], gi\|5103254\|dbj\|BAA78890.1\|... YFI3_ECOLX - Uncharacterized endonuclease OS=Escherichia coli PE=3 SV=1	5.0E-38	[107..273]	[1..152]
gi\|189366704, gi... - gi\|189366704\|gb\|EDU85120.1\| nuclease homolog [Escherichia coli O157:H7 str. EC4501], gi\|168763045\|re... gi\|168790170, gi... - gi\|189370335\|gb\|EDU88751.1\| nuclease homolog [Escherichia coli O157:H7 str. EC869], gi\|168790170\|ref... gi\|3337063, gi\|1... - gi\|3337063\|dbj\|BAA31822.1\| unnamed protein product [Escherichia coli O157:H7 str. Sakai], gi\|1095533... gi\|7435213, gi\|3... - gi\|7435213\|pir\|\|T00303 nuclease homolog - Escherichia coli plasmid pO157, gi\|3337063\|dbj\|BAA31822.1\|... gi\|75994450 - gi\|75994450\|ref\|YP_325563.1\| hypothetical protein L7003 [Escherichia coli O157:H7 EDL933] YFI3_ECO57 - Uncharacterized endonuclease OS=Escherichia coli O157:H7 GN=L7003 PE=3 SV=1	5.0E-38	[107..273]	[1..152]
gi\|149930788, gi... - gi\|37695776\|gb\|AAR00438.1\|AF401292_40 w0002 [Escherichia coli], gi\|149930788\|ref\|YP_001294666.1\| w00...	3.0E-37	[107..273]	[1..152]

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Predicted Domain #1

Region A:
Residues: [1-84]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MREGDSNSKK SADVAVLSII LTGSTLTLIY TYKRYLTQFK RTNDIPRRIF RKHWLYGKVT  60
   61 SVGDGDNFHF FHMPGGIRGG WGWL

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [85-274]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RPVPQMIKND STAEKLVGDS RNMRFFNFNW ITHGRSTKSK IQKAKSQFLK LNVPYKNRKN  60
   61 LPTIPIRLCG IDAPERAHFG NPAQPFGNEA LIWLQNRILG KKVWVKPLSI DQYNRCVARV 120
  121 SYWDWFGGWK DLSLEMLKDG LAVVYEGKVN TEFDDREDKY RYYEFLARSR KKGLWIQNKF 180
  181 ETPGEYKKRI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	31.0
Match:	1ey7A_
Description:	Staphylococcal nuclease
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits