YRC Public Data Repository - Protein Structure Prediction

Protein:	ERG4
Organism:	Saccharomyces cerevisiae
Length:	473 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ERG4.

Description	E-value	Query Range	Subject Range
ERG4 - C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, ... ERG4_YEAST - Delta(24(24(1)))-sterol reductase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ERG4 P...	0.0	[1..473]	[1..473]
LBR_RAT - Lamin-B receptor OS=Rattus norvegicus GN=Lbr PE=1 SV=1	0.0	[8..473]	[183..620]
gi\|19527034, gi\|... - gi\|27502750\|gb\|AAH42522.1\| Lbr protein [Mus musculus], gi\|19527034\|ref\|NP_598576.1\| lamin B receptor...	0.0	[14..473]	[195..626]
gi\|168277676 - gi\|168277676\|dbj\|BAG10816.1\| lamin-B receptor [synthetic construct] gi\|119590148, gi... - gi\|439434\|gb\|AAA59495.1\| integral nuclear envelope inner membrane protein [Homo sapiens], gi\|1890533...	0.0	[27..473]	[196..615]
LBR_CHICK - Lamin-B receptor OS=Gallus gallus GN=LBR PE=1 SV=1	0.0	[22..469]	[189..604]
gi\|16944336 - gi\|16944336\|emb\|CAC18223.2\| probable sterol C-24 reductase [Neurospora crassa]	0.0	[37..472]	[186..621]
ERG24_FUSSO - Delta(14)-sterol reductase OS=Fusarium solani subsp. pisi PE=3 SV=1 gi\|1134869, gi\|3... - sp\|Q01447\|ER24_FUSSO Delta(14)-sterol reductase (C-14 sterol reductase) (Sterol C14-reductase), gi\|1...	0.0	[24..473]	[2..485]
sts1 - C-24(28) sterol reductase Sts1 STS1_SCHPO - Delta(24(24(1)))-sterol reductase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=sts1 PE=...	0.0	[28..473]	[1..453]

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Predicted Domain #1

Region A:
Residues: [1-473]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAKDNSEKLQ VQGEEKKSKQ PVNFLPQGKW LKPNEIEYEF GGTTGVIGML IGFPLLMYYM  60
   61 WICAEFYHGK VALPKAGESW MHFIKHLYQL VLENGIPEKY DWTIFLTFWV FQIIFYYTLP 120
  121 GIWTKGQPLS HLKGKQLPYF CNAMWTLYVT TTLVLVLHFT NLFRLYVIID RFGRIMTCAI 180
  181 ISGFAFSIIL YLWTLFISHD YHRMTGNHLY DFFMGAPLNP RWGILDLKMF FEVRLPWFTL 240
  241 YFITLGACLK QWETYGYVTP QLGVVMLAHW LYANACAKGE ELIVPTWDMA YEKFGFMLIF 300
  301 WNIAGVPYTY CHCTLYLYYH DPSEYHWSTL YNVSLYVVLL CAYYFFDTAN AQKNAFRKQM 360
  361 SGDKTGRKTF PFLPYQILKN PKYMVTSNGS YLLIDGWYTL ARKIHYTADW TQSLVWALSC 420
  421 GFNSVFPWFF PVFFLVVLIH RAFRDQAKCK RKYGKDWDEY CKHCPYVFIP YVF

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	1000.0
Match:	PF01222
Description:	Ergosterol biosynthesis ERG4/ERG24 family

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits