YRC Public Data Repository - Protein Structure Prediction

Protein:	DUG1
Organism:	Saccharomyces cerevisiae
Length:	481 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DUG1.

Description	E-value	Query Range	Subject Range
gi\|15620780 - gi\|15620780\|emb\|CAC69883.1\| glutamate carboxypeptidase [Homo sapiens]	0.0	[2..480]	[1..475]
CNDP2_MOUSE - Cytosolic non-specific dipeptidase OS=Mus musculus GN=Cndp2 PE=1 SV=1	0.0	[2..479]	[1..474]
DUG1 - Cys-Gly metallo-di-peptidase; forms a complex with Dug2p and Dug3p to degrade glutathione (GSH) and ... DUG1_YEAST - Cys-Gly metallodipeptidase DUG1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DUG1 PE=... gi\|207345611 - gi\|207345611\|gb\|EDZ72376.1\| YFR044Cp-like protein [Saccharomyces cerevisiae AWRI1631]	7.0E-97	[1..481]	[1..481]
DUG1_SCHPO - Cys-Gly metallodipeptidase dug1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=dug1 PE=2 ... SPBC1198.08 - dipeptidase Dug1	2.0E-94	[4..478]	[2..472]
pes-9 - Yeast hypothetical 52.9 KD protein like status:Confirmed UniProt:O18000 protein_id:CAB07646.1	2.0E-91	[1..477]	[1..472]
gi\|25312288 - pir\|\|C84134 hypothetical protein BH3875 [imported] - Bacillus halodurans (strain C-125) gi\|15616437, gi\|... - gi\|15616437\|ref\|NP_244742.1\| hypothetical protein BH3875 [Bacillus halodurans C-125], gi\|10176500\|db...	7.0E-84	[5..481]	[1..458]
gi\|25520910 - pir\|\|G97371 argE/dapE/acy1 family protein [imported] - Agrobacterium tumefaciens (strain C58, Cereon... gi\|15154979, gi\|... - gi\|15887462\|ref\|NP_353143.1\| hypothetical protein AGR_C_165 [Agrobacterium tumefaciens str. C58], gi...	8.0E-84	[2..477]	[45..506]
gi\|25527699 - pir\|\|AE3480 aminoacylase (EC 3.5.1.14) [imported] - Brucella melitensis (strain 16M) gi\|17988110, gi\|... - gi\|17988110\|ref\|NP_540744.1\| hypothetical protein BMEI1827 [Brucella melitensis 16M], gi\|17983863\|gb...	1.0E-83	[1..477]	[13..480]
gi\|15073105 - gi\|15073105\|emb\|CAC41564.1\| Putative succinyl-diaminopimelate desuccinylase [Sinorhizobium meliloti ... gi\|15963930 - gi\|15963930\|ref\|NP_384283.1\| hypothetical protein SMc02852 [Sinorhizobium meliloti 1021]	1.0E-83	[1..476]	[1..462]

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Predicted Domain #1

Region A:
Residues: [1-217]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSHSLTSVFQ KIDSLKPQFF SRLTKAIQIP AVSSDESLRS KVFDKAKFIS EQLSQSGFHD  60
   61 IKMVDLGIQP PPISTPNLSL PPVILSRFGS DPSKKTVLVY GHYDVQPAQL EDGWDTEPFK 120
  121 LVIDEAKGIM KGRGVTDDTG PLLSWINVVD AFKASGQEFP VNLVTCFEGM EESGSLKLDE 180
  181 LIKKEANGYF KGVDAVCISD NYWLGTKKPV LTYGLRG

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [387-481]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GAYWVSDPFN AQFTAAKKAT KLVYGVDPDF TREGGSIPIT LTFQDALNTS VLLLPMGRGD  60
   61 DGAHSINEKL DISNFVGGMK TMAAYLQYYS ESPEN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	39.522879
Match:	1cg2A_
Description:	Carboxypeptidase G2, catalytic domain; Carboxypeptidase G2
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [218-386]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CNYYQTIIEG PSADLHSGIF GGVVAEPMID LMQVLGSLVD SKGKILIDGI DEMVAPLTEK  60
   61 EKALYKDIEF SVEELNAATG SKTSLYDKKE DILMHRWRYP SLSIHGVEGA FSAQGAKTVI 120
  121 PAKVFGKFSI RTVPDMDSEK LTSLVQKHCD AKFKSLNSPN KCRTELIHD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	39.522879
Match:	1cg2A_
Description:	Carboxypeptidase G2, catalytic domain; Carboxypeptidase G2
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits