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View Structure Prediction Details

Protein: COS4
Organism: Saccharomyces cerevisiae
Length: 379 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for COS4.

Description E-value Query
Range
Subject
Range
COS1 - Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-enc...
COS1_YEAST - Protein COS1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=COS1 PE=1 SV=1
588.0 [0..1] [379..1]

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Predicted Domain #1
Region A:
Residues: [1-61]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKENELKNEK SVDVLSFKQL ESQKIVLPQD LFRSSFTWFC YEIYKSLAFR IWMLLWLPLS  60
   61 V

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [62-168]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WWKLSNNWIY PLMVSLLVLF WGPVFVLVIF RLSRKRSLSK QLTQFCKEIT KSTPSSDPHD  60
   61 WEVVAANLNS YLYENKAWNI RYFFFNAMGC QEAFRTTLLE PFSLKKD

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 46.30103
Match: PF00674
Description: DUP family

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.957 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.938 N/A N/A a.24.21 Description not found.
View Download 0.938 N/A N/A a.29.4 RecG, N-terminal domain
View Download 0.932 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.932 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.899 N/A N/A a.24.17 Group V grass pollen allergen
View Download 0.899 N/A N/A a.24.17 Group V grass pollen allergen
View Download 0.888 N/A N/A a.29.2 Bromodomain
View Download 0.888 N/A N/A a.29.2 Bromodomain

Predicted Domain #3
Region A:
Residues: [169-241]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EAAKVKSFKD SVPYIEEALG VYFREVEKQW KLFNSEKSWS PVGLEDAKLP KEAYRFKLTW  60
   61 FLKRISNIFM LIP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.847 d.58.17 Metal-binding domain
View Download 0.777 d.74.5 Hypothetical protein Yml108w
View Download 0.747 d.58.49 YajQ-like
View Download 0.747 d.58.49 YajQ-like
View Download 0.709 a.163.1 Crustacean CHH/MIH/GIH neurohormone
View Download 0.709 a.163.1 Crustacean CHH/MIH/GIH neurohormone
View Download 0.650 d.58.17 Metal-binding domain
View Download 0.649 d.58.17 Metal-binding domain
View Download 0.649 d.58.17 Metal-binding domain
View Download 0.541 d.57.1 DNA damage-inducible protein DinI

Predicted Domain #4
Region A:
Residues: [242-379]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FLNFLCCIYV SRGMCLLLRT LYLGWILFML VQGFQNIRVL IMSMEHKMQF LSTIINEQES  60
   61 GANGWDEIAR KMNRYLFEKK VWKNEEFFFD GIDCEWFFSH FFYRVLSAKK SMRALSLNVE 120
  121 LWPYIKEAQL SCSEESLA

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 59.275724
Match: PF00674
Description: DUP family

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.692 N/A N/A a.160.1 Poly(A) polymerase, middle domain
View Download 0.510 N/A N/A a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.510 N/A N/A a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.481 N/A N/A a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.437 N/A N/A d.153.1 N-terminal nucleophile aminohydrolases (Ntn hydrolases)
View Download 0.437 N/A N/A d.153.1 N-terminal nucleophile aminohydrolases (Ntn hydrolases)
View Download 0.370 N/A N/A a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.370 N/A N/A a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.367 N/A N/A d.58.44 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains
View Download 0.367 N/A N/A d.58.44 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle