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View Structure Prediction Details

Protein: MOB2
Organism: Saccharomyces cerevisiae
Length: 287 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MOB2.

Description E-value Query
Range
Subject
Range
MOB2 - Component of the RAM signaling network, that activates the Cbk1p kinase, thereby facilitating the Ac...
gi|190406540 - gi|190406540|gb|EDV09807.1| maintenance of ploidy protein MOB2 [Saccharomyces cerevisiae RM11-1a]
MOB2_YEAST - CBK1 kinase activator protein MOB2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MOB2 ...
0.0 [1..287] [1..287]
gi|2832633, gi|7... - pir||T04426 hypothetical protein T18B16.20 - Arabidopsis thaliana, gi|7268700|emb|CAB78907.1| putat...
4.0E-92 [56..278] [1171..1401]
MOL1B_PONPY - Mps one binder kinase activator-like 1B - Pongo pygmaeus (Orangutan)
gi|55606148 - gi|55606148|ref|XP_515735.1| PREDICTED: Mob4B protein isoform 4 [Pan troglodytes]
tr|G1SUR2|G1SUR2... - Uncharacterized protein OS=Oryctolagus cuniculus GN=MOB1A PE=4 SV=2
MOB1A_MOUSE - MOB kinase activator 1A OS=Mus musculus GN=Mob1a PE=2 SV=3
MOBKL1B - MOB1, Mps One Binder kinase activator-like 1B (yeast)
MOB1A_PONAB - MOB kinase activator 1A OS=Pongo abelii GN=MOB1A PE=2 SV=3
MOB1A_RAT - MOB kinase activator 1A OS=Rattus norvegicus GN=Mob1a PE=2 SV=3
gi|111305145, gi... - gi|76628940|ref|XP_871266.1| PREDICTED: similar to Mob4B protein [Bos taurus], gi|115496426|ref|NP_0...
gi|73980517 - gi|73980517|ref|XP_852858.1| PREDICTED: similar to Mob4B protein isoform 1 [Canis familiaris]
6.0E-90 [68..278] [5..211]
CE18580 - status:Confirmed UniProt:Q7JLW3 protein_id:CAA93647.1
2.0E-86 [3..275] [22..294]

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Predicted Domain #1
Region A:
Residues: [1-64]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFFNFKAFG RNSKKNKNQP LNVAQPPAMN TIYSSPHSSN SRLSLRNKHH SPKRHSQTSF  60
   61 PAQK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.400 a.60.1 SAM/Pointed domain
View Download 0.301 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.330 a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.338 a.60.3 C-terminal domain of RNA polymerase alpha subunit
View Download 0.400 a.60.1 SAM/Pointed domain
View Download 0.338 a.60.3 C-terminal domain of RNA polymerase alpha subunit
View Download 0.330 a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.323 a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.323 a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.311 a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.254 a.4.5 "Winged helix" DNA-binding domain
View Download 0.239 a.60.2 RuvA domain 2-like
View Download 0.235 a.4.2 Methylated DNA-protein cysteine methyltransferase, C-terminal domain

Predicted Domain #2
Region A:
Residues: [65-287]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 STPQSQQLTS TTPQSQQQEA SERSESQQIM FLSEPFVRTA LVKGSFKTIV QLPKYVDLGE  60
   61 WIALNVFEFF TNLNQFYGVV AEYVTPDAYP TMNAGPHTDY LWLDANNRQV SLPASQYIDL 120
  121 ALTWINNKVN DKNLFPTKNG LPFPQQFSRD VQRIMVQMFR IFAHIYHHHF DKIVHLSLEA 180
  181 HWNSFFSHFI SFAKEFKIID RKEMAPLLPL IESFEKQGKI IYN

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 112.142668
Match: PF03637
Description: Mob1/phocein family

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted functions:

Term Confidence Notes
binding 1.92301852481284 bayes_pls_golite062009
kinase regulator activity 1.89112613830997 bayes_pls_golite062009
enzyme regulator activity 1.85961781963242 bayes_pls_golite062009
protein binding 1.70532605681329 bayes_pls_golite062009
protein kinase regulator activity 1.22656624834768 bayes_pls_golite062009
enzyme activator activity 1.01199608762933 bayes_pls_golite062009
kinase activator activity 0.48120280834988 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle