YRC Public Data Repository - Protein Structure Prediction

Protein:	TRP2
Organism:	Saccharomyces cerevisiae
Length:	507 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TRP2.

Description	E-value	Query Range	Subject Range
gi\|207345914 - gi\|207345914\|gb\|EDZ72578.1\| YER090Wp-like protein [Saccharomyces cerevisiae AWRI1631] TRPE_YEAST - Anthranilate synthase component 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TRP2 P... TRP2 - Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional ... gi\|190405654 - gi\|190405654\|gb\|EDV08921.1\| anthranilate synthase component I [Saccharomyces cerevisiae RM11-1a]	0.0	[1..507]	[1..507]
gi\|17227824, gi\|... - gi\|17227824\|ref\|NP_484372.1\| anthranilate synthase component I [Nostoc sp. PCC 7120], gi\|17129673\|db... gi\|25291358 - pir\|\|AG1847 anthranilate synthetase alpha-chain [imported] - Nostoc sp. (strain PCC 7120)	0.0	[7..494]	[2..501]
gi\|67916452, gi\|... - gi\|67916452\|ref\|ZP_00510162.1\| Anthranilate synthase component I [Clostridium thermocellum ATCC 2740... TRPE_CLOTM - Anthranilate synthase component 1 OS=Clostridium thermocellum GN=trpE PE=3 SV=1	0.0	[7..499]	[2..493]
TRPE_SCHPO - Probable anthranilate synthase component 1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN... trp3 - anthranilate synthase component I	0.0	[5..507]	[1..488]
TRPE_PSEPU - Anthranilate synthase component 1 OS=Pseudomonas putida GN=trpE PE=3 SV=1	0.0	[10..502]	[2..493]
TRPE_PSESS - Anthranilate synthase component 1 OS=Pseudomonas savastanoi GN=trpE PE=3 SV=1 gi\|151623 - gi\|151623\|gb\|AAA26016.1\| anthranilate synthase large subunit [Pseudomonas syringae]	0.0	[10..489]	[2..480]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[10..489]	[2..480]
TRPE_ARATH - Anthranilate synthase alpha subunit 1, chloroplastic OS=Arabidopsis thaliana GN=ASA1 PE=1 SV=1	0.0	[5..503]	[55..595]
gi\|11268487, gi\|... - gi\|5051452\|emb\|CAB44973.1\| putative anthranilate synthase component I [Neisseria meningitidis], pir\|... TRPE_NEIMA - Anthranilate synthase component 1 OS=Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)... TRPE_NEIMA - Anthranilate synthase component 1 OS=Neisseria meningitidis serogroup A GN=trpE PE=3 SV=1	0.0	[15..498]	[4..487]

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Predicted Domain #1

Region A:
Residues: [1-507]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTASIKIQPD IDSLKQLQQQ NDDSSINMYP VYAYLPSLDL TPHVAYLKLA QLNNPDRKES  60
   61 FLLESAKTNN ELDRYSFIGI SPRKTIKTGP TEGIETDPLE ILEKEMSTFK VAENVPGLPK 120
  121 LSGGAIGYIS YDCVRYFEPK TRRPLKDVLR LPEAYLMLCD TIIAFDNVFQ RFQIIHNINT 180
  181 NETSLEEGYQ AAAQIITDIV SKLTDDSSPI PYPEQPPIKL NQTFESNVGK EGYENHVSTL 240
  241 KKHIKKGDII QGVPSQRVAR PTSLHPFNIY RHLRTVNPSP YLFYIDCLDF QIIGASPELL 300
  301 CKSDSKNRVI THPIAGTVKR GATTEEDDAL ADQLRGSLKD RAEHVMLVDL ARNDINRICD 360
  361 PLTTSVDKLL TIQKFSHVQH LVSQVSGVLR PEKTRFDAFR SIFPAGTVSG APKVRAMELI 420
  421 AELEGERRGV YAGAVGHWSY DGKTMDNCIA LRTMVYKDGI AYLQAGGGIV YDSDEYDEYV 480
  481 ETMNKMMANH STIVQAEELW ADIVGSA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	742.228787
Match:	1qdlA_
Description:	Anthranilate synthase aminodeoxyisochorismate synthase/lyase subunit, TrpE
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
anthranilate synthase activity	11.4918303265177	bayes_pls_golite062009
4-amino-4-deoxychorismate synthase activity	9.91522831720207	bayes_pls_golite062009
oxo-acid-lyase activity	9.57649905871948	bayes_pls_golite062009
carbon-carbon lyase activity	2.42362294309332	bayes_pls_golite062009
catalytic activity	2.11110806828104	bayes_pls_golite062009
binding	1.73874372115438	bayes_pls_golite062009
lyase activity	0.454734323696838	bayes_pls_golite062009
protein binding	0.323833479841771	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: