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View Structure Prediction Details

Protein: SPC25
Organism: Saccharomyces cerevisiae
Length: 221 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPC25.

Description E-value Query
Range
Subject
Range
SPC25 - Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-...
SPC25_YEAST - Kinetochore protein SPC25 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SPC25 PE=1 SV=...
gi|151944727 - gi|151944727|gb|EDN62986.1| spindle pole component [Saccharomyces cerevisiae YJM789]
2.0E-55 [1..221] [1..221]
K2C8_BOVIN - (P05786) Keratin, type II cytoskeletal 8 (Cytokeratin-8) (CK-8) (Keraton-8) (K8) (Cytokeratin-A) (Fr...
1.0E-34 [2..133] [218..365]
KRT84 - keratin 84
1.0E-34 [2..156] [393..546]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
2.0E-32 [2..105] [319..422]

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Predicted Domain #1
Region A:
Residues: [1-151]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASIDAFSDL ERRMDGFQKD VAQVLARQQN HARQQLQQFQ AEMRQLHNQH QHLIDELQRL  60
   61 ATQRTALQQQ IHAAQQATNT TREQWRSYHE RESELSRRQS TLAAQSRELD SLLQQRGKEC 120
  121 VQLRARWAAQ SGNDAAEVAL YERLLQLRVL P

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 23.0
Match: 1gk4A_
Description: Vimentin coil
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [152-221]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GASDVHDVRF VFGDDSRCWI EVAMHGDHVI GNSHPALDPK SRATLEHVLT VQGDLAAFLV  60
   61 VARDMLLASL 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.629 b.36.1 PDZ domain-like
View Download 0.537 b.40.4 Nucleic acid-binding proteins
View Download 0.505 d.93.1 SH2 domain
View Download 0.497 a.48.3 Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
View Download 0.490 b.61.3 D-aminopeptidase, middle and C-terminal domains
View Download 0.474 a.60.4 DNA repair protein Rad51, N-terminal domain
View Download 0.416 d.50.1 dsRNA-binding domain-like
View Download 0.409 a.144.1 PABC (PABP) domain
View Download 0.395 b.40.4 Nucleic acid-binding proteins
View Download 0.394 b.40.4 Nucleic acid-binding proteins
View Download 0.394 d.87.1 FAD/NAD-linked reductases, dimerisation (C-terminal) domain
View Download 0.389 b.40.6 MOP-like
View Download 0.384 b.71.1 Glycosyl hydrolase domain
View Download 0.383 d.87.1 FAD/NAD-linked reductases, dimerisation (C-terminal) domain
View Download 0.381 a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.375 b.40.6 MOP-like
View Download 0.367 b.40.4 Nucleic acid-binding proteins
View Download 0.363 b.114.1 N-utilization substance G protein NusG, insert domain
View Download 0.361 d.15.7 Immunoglobulin-binding domains
View Download 0.361 b.71.1 Glycosyl hydrolase domain
View Download 0.360 d.95.1 Glucose permease domain IIB
View Download 0.342 b.40.4 Nucleic acid-binding proteins
View Download 0.334 d.87.1 FAD/NAD-linked reductases, dimerisation (C-terminal) domain
View Download 0.332 b.55.1 PH domain-like
View Download 0.329 b.40.4 Nucleic acid-binding proteins
View Download 0.313 d.15.1 Ubiquitin-like
View Download 0.298 g.18.1 Complement control module/SCR domain
View Download 0.287 a.4.5 "Winged helix" DNA-binding domain
View Download 0.284 d.64.1 eIF1-like
View Download 0.259 a.50.1 Anaphylotoxins (complement system)
View Download 0.257 a.156.1 S13-like H2TH domain
View Download 0.246 d.212.1 TolA/TonB C-terminal domain
View Download 0.245 a.60.1 SAM/Pointed domain
View Download 0.240 a.163.1 Crustacean CHH/MIH/GIH neurohormone
View Download 0.239 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.234 c.55.7 Methylated DNA-protein cysteine methyltransferase domain
View Download 0.233 b.84.2 Rudiment single hybrid motif
View Download 0.229 d.58.10 Acylphosphatase-like
View Download 0.228 b.15.1 HSP20-like chaperones
View Download 0.222 b.40.4 Nucleic acid-binding proteins
View Download 0.220 d.93.1 SH2 domain
View Download 0.213 d.58.18 Regulatory domain in the aminoacid metabolism
View Download 0.212 b.36.1 PDZ domain-like
View Download 0.212 d.199.1 DNA-binding C-terminal domain of the transcription factor MotA
View Download 0.211 d.87.1 FAD/NAD-linked reductases, dimerisation (C-terminal) domain
View Download 0.208 d.93.1 SH2 domain
View Download 0.205 d.87.1 FAD/NAD-linked reductases, dimerisation (C-terminal) domain
View Download 0.205 b.1.2 Fibronectin type III
View Download 0.204 d.93.1 SH2 domain


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle