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View Structure Prediction Details

Protein: NPP2
Organism: Saccharomyces cerevisiae
Length: 493 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NPP2.

Description E-value Query
Range
Subject
Range
NPP2_YEAST - Ectonucleotide pyrophosphatase/phosphodiesterase 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 /...
NPP2 - Nucleotide pyrophosphatase/phosphodiesterase family member; mediates extracellular nucleotide phosph...
0.0 [1..493] [1..493]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
2.0E-89 [57..491] [195..591]
gi|219945, gi|13... - gi|219945|dbj|BAA02054.1| nucleotide pyrophosphatase [Homo sapiens], gi|189650|gb|AAA63237.1| plasma...
3.0E-89 [57..491] [143..539]
gi|16588834 - gi|16588834|gb|AAL26912.1| ecto-nucleotide pyrophosphatase [Rattus norvegicus]
3.0E-89 [62..491] [178..573]
gi|148672837, gi... - gi|15099945|gb|AAK84174.1|AF339910_1 ectonucleotide pyrophosphatase/phosphodiesterase 1 allotype b [...
5.0E-88 [62..491] [178..573]

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Predicted Domain #1
Region A:
Residues: [1-68]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLLFEQPVDL EKNNEDDTNI KPFAISRHFL LKLLLCGIIL IELLLYSKCP KPIDNGPRTI  60
   61 ANRSNTYF

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [69-493]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NGTHDFKTLT ILISIDGFHP RLIDAKYTPF LYNLHNLRSP YDMNITTAPY MIPSFPTQTF  60
   61 PNHWSMVTGK YPIEHGIVSN IFWDNFTSSE FRPNNLDARI WSNTADPIWQ LLQTESQGEY 120
  121 KVATHMWPGS EVVYEDHGDV PRERMPFYFG KFNQWEKLQD KLAQIFRYID MPQLKDRPEL 180
  181 VISYIPNVDS YGHSFGYDLR DKRLQKLIGE VDGFFLDLIE GLQKRNLLKI SNVMIVSDHG 240
  241 MSNVNANDGE HVVVWERVFP ADAMSAFISH LYNEGPMMMV CLKNPRDKQW ICDLIEAQLE 300
  301 KAYGDEISRK FHVILKEDFD PSWKYFQYDN RKHRYDDRVG DIWILADEYY AIVKEMGDVP 360
  361 IGIMGTHGYN FNNCSDMASI FIGMGPMFNN EVVPPFENIE VYNMLIKASA LLGEEKTKKE 420
  421 KSLLQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 44.30103
Match: 1e1zP_
Description: Arylsulfatase A
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle