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View Structure Prediction Details

Protein: EUG1
Organism: Saccharomyces cerevisiae
Length: 517 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EUG1.

Description E-value Query
Range
Subject
Range
EUG1 - Protein disulfide isomerase of the endoplasmic reticulum lumen, function overlaps with that of Pdi1p...
EUG1_YEAST - Protein disulfide-isomerase EUG1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=EUG1 PE...
0.0 [1..517] [1..517]
gi|5326749 - gi|5326749|gb|AAD42032.1|AF075246_1 protein disulfide isomerase precursor [Kluyveromyces marxianus]
0.0 [1..507] [1..500]
PDI_ASPNG - Protein disulfide-isomerase OS=Aspergillus niger GN=pdiA PE=2 SV=1
0.0 [6..517] [2..515]
PDIA1_RABIT - Protein disulfide-isomerase OS=Oryctolagus cuniculus GN=P4HB PE=2 SV=1
0.0 [8..517] [1..509]
gi|5650705, gi|4... - gi|5650705|emb|CAB51612.1| protein disulfide isomerase [Kluyveromyces lactis], gi|49641377|emb|CAH01...
gi|50304577, gi|... - gi|50304577|ref|XP_452244.1| unnamed protein product [Kluyveromyces lactis], gi|49641377|emb|CAH0109...
0.0 [13..498] [11..491]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [1..507] [1..505]
PDIA1_MOUSE, PDI... - (P09103) Protein disulfide-isomerase precursor (EC 5.3.4.1) (PDI) (Prolyl 4-hydroxylase beta subunit...
0.0 [8..517] [1..509]
SPAC1F5.02 - protein disulfide isomerase
PDI1_SCHPO - Putative protein disulfide-isomerase C1F5.02 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) ...
0.0 [17..517] [6..492]

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Predicted Domain #1
Region A:
Residues: [1-146]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQVTTRFISA IVSFCLFASF TLAENSARAT PGSDLLVLTE KKFKSFIESH PLVLVEFFAP  60
   61 WCLHSQILRP HLEEAASILK EHNVPVVQID CEANSMVCLQ QTINTYPTLK IFKNGRIFDG 120
  121 QVYRGVKITD EITQYMIQLY EASVIY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 140.29073
Match: 1mek__
Description: Protein disulfide isomerase, PDI
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [147-255]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LNSEDEIQPY LENATLPVVI NRGLTGLNET YQEVALDLAE DYVFLSLLDS EDKSLSIHLP  60
   61 NTTEPILFDG NVDSLVGNSV ALTQWLKVVI LPYFTDIEPD LFPKYISSN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 7.39794
Match: 1bjx__
Description: Protein disulfide isomerase, PDI
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [256-330]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPLAYFFYTS EEELEDYTDL FTQLGKENRG QINFIALNST MFPHHVRFLN MREQFPLFAI  60
   61 HNMINNLKYG LPQLP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.722 0.979 protein disulfide isomerase activity c.47.1 Thioredoxin-like
View Download 0.805 0.004 protein disulfide isomerase activity d.58.17 Metal-binding domain
View Download 0.942 0.003 protein disulfide isomerase activity c.51.1 Anticodon-binding domain of Class II aaRS
View Download 0.622 N/A N/A c.51.1 Anticodon-binding domain of Class II aaRS
View Download 0.603 N/A N/A c.44.2 Enzyme IIB-cellobiose
View Download 0.571 N/A N/A c.58.1 Aminoacid dehydrogenase-like, N-terminal domain
View Download 0.538 N/A N/A c.47.1 Thioredoxin-like
View Download 0.523 N/A N/A d.52.1 Alpha-lytic protease prodomain
View Download 0.506 N/A N/A c.30.1 PreATP-grasp domain
View Download 0.487 N/A N/A d.51.1 Eukaryotic type KH-domain (KH-domain type I)
View Download 0.465 N/A N/A d.58.12 eEF-1beta-like
View Download 0.460 N/A N/A c.47.2 RNA 3'-terminal phosphate cyclase, RPTC, insert domain
View Download 0.457 N/A N/A c.47.1 Thioredoxin-like
View Download 0.433 N/A N/A d.58.1 4Fe-4S ferredoxins
View Download 0.421 N/A N/A d.58.5 GlnB-like
View Download 0.405 N/A N/A d.57.1 DNA damage-inducible protein DinI
View Download 0.401 N/A N/A d.58.7 RNA-binding domain, RBD
View Download 0.394 N/A N/A c.15.1 BRCT domain
View Download 0.373 N/A N/A d.68.1 Translation initiation factor IF3, C-terminal domain
View Download 0.364 N/A N/A c.13.2 Anti-sigma factor antagonist SpoIIaa
View Download 0.352 N/A N/A d.68.3 SirA-like
View Download 0.347 N/A N/A a.60.1 SAM/Pointed domain
View Download 0.343 N/A N/A c.51.1 Anticodon-binding domain of Class II aaRS
View Download 0.329 N/A N/A d.74.3 RBP11-like subunits of RNA polymerase
View Download 0.328 N/A N/A c.114.1 YchN-like
View Download 0.317 N/A N/A a.35.1 lambda repressor-like DNA-binding domains
View Download 0.311 N/A N/A c.55.7 Methylated DNA-protein cysteine methyltransferase domain
View Download 0.309 N/A N/A a.20.1 PGBD-like
View Download 0.306 N/A N/A d.58.11 EF-G/eEF-2 domains III and V
View Download 0.303 N/A N/A d.58.25 Killer toxin KP6 alpha-subunit
View Download 0.296 N/A N/A c.47.1 Thioredoxin-like
View Download 0.289 N/A N/A d.58.44 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains
View Download 0.286 N/A N/A d.58.7 RNA-binding domain, RBD
View Download 0.284 N/A N/A a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.282 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.278 N/A N/A a.77.1 DEATH domain
View Download 0.262 N/A N/A d.237.1 Hypothetical protein YjiA, C-terminal domain
View Download 0.258 N/A N/A c.78.2 Aspartate/glutamate racemase
View Download 0.258 N/A N/A d.74.1 Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH)
View Download 0.251 N/A N/A d.58.14 Ribosomal protein S6
View Download 0.251 N/A N/A c.102.1 Cell-division inhibitor MinC, N-terminal domain
View Download 0.245 N/A N/A d.230.3 Amyloid beta a4 protein copper binding domain (domain 2)
View Download 0.244 N/A N/A d.94.1 HPr-like
View Download 0.240 N/A N/A c.23.1 CheY-like
View Download 0.238 N/A N/A d.45.1 ClpS-like
View Download 0.238 N/A N/A a.60.8 HRDC-like
View Download 0.235 N/A N/A d.58.8 Viral DNA-binding domain
View Download 0.221 N/A N/A d.58.17 Metal-binding domain
View Download 0.214 N/A N/A d.58.36 Sulfite reductase, domains 1 and 3
View Download 0.212 N/A N/A c.47.1 Thioredoxin-like
View Download 0.212 N/A N/A d.58.7 RNA-binding domain, RBD
View Download 0.207 N/A N/A c.51.3 B12-dependend dehydatases associated subunit
View Download 0.205 N/A N/A c.47.1 Thioredoxin-like
View Download 0.201 N/A N/A a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain

Predicted Domain #4
Region A:
Residues: [331-517]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EEEYAKLEKP QPLDRDMIVQ LVKDYREGTA KPIVKSEEIP KEQKSNVYKI VGKTHDDIVH  60
   61 DDDKDVLVKY YATWCIHSKR FAPIYEEIAN VLASDESVRD KILIAEVDSG ANDILSFPVT 120
  121 GYPTIALYPA GNNSKPIIFN KIRNLEDVFE FIKESGTHHI DGQAIYDKLH QAKDSEVSTE 180
  181 DTVHDEL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 70.70927
Match: 1dbyA_
Description: Thioredoxin
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle