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View Structure Prediction Details

Protein: PHO8
Organism: Saccharomyces cerevisiae
Length: 566 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PHO8.

Description E-value Query
Range
Subject
Range
PPB_YEAST - Repressible alkaline phosphatase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PHO8 PE...
PHO8 - Repressible alkaline phosphatase, a glycoprotein localized to the vacuole; regulated by levels of in...
0.0 [1..566] [1..566]
gi|3510651 - gi|3510651|gb|AAC33853.1| intestinal alkaline phosphatase III; IAP III [Bos taurus]
0.0 [50..552] [36..509]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [50..549] [36..506]
gi|178446 - gi|178446|gb|AAA51704.1| intestinal alkaline phosphatase precursor
0.0 [50..549] [36..506]

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Predicted Domain #1
Region A:
Residues: [1-566]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMTHTLPSEQ TRLVPGSDSS SRPKKRRISK RSKIIVSTVV CIGLLLVLVQ LAFPSSFALR  60
   61 SASHKKKNVI FFVTDGMGPA SLSMARSFNQ HVNDLPIDDI LTLDEHFIGS SRTRSSDSLV 120
  121 TDSAAGATAF ACALKSYNGA IGVDPHHRPC GTVLEAAKLA GYLTGLVVTT RITDATPASF 180
  181 SSHVDYRWQE DLIATHQLGE YPLGRVVDLL MGGGRSHFYP QGEKASPYGH HGARKDGRDL 240
  241 IDEAQSNGWQ YVGDRKNFDS LLKSHGENVT LPFLGLFADN DIPFEIDRDE KEYPSLKEQV 300
  301 KVALGALEKA SNEDKDSNGF FLMVEGSRID HAGHQNDPAS QVREVLAFDE AFQYVLEFAE 360
  361 NSDTETVLVS TSDHETGGLV TSRQVTASYP QYVWYPQVLA NATHSGEFLK RKLVDFVHEH 420
  421 KGASSKIENF IKHEILEKDL GIYDYTDSDL ETLIHLDDNA NAIQDKLNDM VSFRAQIGWT 480
  481 THGHSAVDVN IYAYANKKAT WSYVLNNLQG NHENTEVGQF LENFLELNLN EVTDLIRDTK 540
  541 HTSDFDATEI ASEVQHYDEY YHELTN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 481.0
Match: 1ew2A_
Description: Alkaline phosphatase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
hydrolase activity, acting on ester bonds 6.35436087302893 bayes_pls_golite062009
phosphatase activity 5.08780872782393 bayes_pls_golite062009
phosphoric ester hydrolase activity 4.87860141195575 bayes_pls_golite062009
hydrolase activity 4.01787687283658 bayes_pls_golite062009
arylsulfatase activity 3.10080557624784 bayes_pls_golite062009
catalytic activity 2.31328968099128 bayes_pls_golite062009
sulfuric ester hydrolase activity 2.02024402809818 bayes_pls_golite062009
binding 0.543713736726232 bayes_pls_golite062009
protein binding 0.322439940070363 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.206358849559315 bayes_pls_golite062009
kinase activity 0.194466496743156 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.0492613068838462 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
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