YRC Public Data Repository - Protein Structure Prediction

Protein:	CTS2
Organism:	Saccharomyces cerevisiae
Length:	511 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CTS2.

Description	E-value	Query Range	Subject Range
CHI2_YEAST - Sporulation-specific chitinase 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CTS2 PE... CTS2 - Protein similar to Ashbya gossypii sporulation-specific chitinase	0.0	[1..511]	[1..511]
gi\|7804919 - gi\|7804919\|gb\|AAF70180.1\|AF251793_1 extracellular chitinase ChiA [Aeromonas hydrophila]	0.0	[27..506]	[110..589]
gi\|483820 - gi\|483820\|gb\|AAA93130.1\| chitinase protein precursor [Aeromonas punctata]	0.0	[27..506]	[110..588]
gi\|25486807 - pir\|\|D83764 chitinase BH0916 [imported] - Bacillus halodurans (strain C-125) gi\|15613479, gi\|... - gi\|15613479\|ref\|NP_241782.1\| chitinase [Bacillus halodurans C-125], gi\|10173531\|dbj\|BAB04635.1\| chit...	0.0	[67..511]	[34..498]
gi\|123187380 - gi\|123187380\|gb\|ABM69267.1\| ChiA [Serratia sp. KCK] gi\|12746408 - gi\|12746408\|gb\|AAK07482.1\| endochitinase A [Serratia liquefaciens]	0.0	[27..476]	[110..563]
gi\|17225117 - gi\|17225117\|gb\|AAL37255.1\| chitinase A [Vibrio parahaemolyticus]	0.0	[27..504]	[111..615]
gi\|229371752, gi... - gi\|229605266\|ref\|YP_002875970.1\| chitinase [Vibrio cholerae MJ-1236], gi\|229371752\|gb\|ACQ62174.1\| ch... gi\|229345492, gi... - gi\|229517456\|ref\|ZP_04406901.1\| chitinase [Vibrio cholerae RC9], gi\|229345492\|gb\|EEO10465.1\| chitina... gi\|15600798, gi\|... - gi\|9657407\|gb\|AAF95941.1\| chitinase [Vibrio cholerae O1 biovar eltor str. N16961], gi\|15600798\|ref\|N... gi\|11354465 - pir\|\|D82510 chitinase VCA0027 [imported] - Vibrio cholerae (strain N16961 serogroup O1) gi\|229352858, gi... - gi\|229510413\|ref\|ZP_04399893.1\| chitinase [Vibrio cholerae B33], gi\|229352858\|gb\|EEO17798.1\| chitina... gi\|254846000, gi... - gi\|254850295\|ref\|ZP_05239645.1\| chitinase [Vibrio cholerae MO10], gi\|254846000\|gb\|EET24414.1\| chitin...	0.0	[23..507]	[107..619]
gi\|158937165 - gi\|158937165\|dbj\|BAF91600.1\| chitinase [Vibrio parahaemolyticus] gi\|12830478, gi\|... - gi\|12830478\|emb\|CAC29091.1\| chitinase [Vibrio alginolyticus], gi\|12697608\|dbj\|BAB21607.1\| chitinase ...	0.0	[27..507]	[111..618]

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Predicted Domain #1

Region A:
Residues: [1-69]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVGHSAQHRS KSSLVSHLLI LLIFITIIIE MCLYNKIFKN QRSDDIRDNF NNGGHRVPSN  60
   61 VQNHGTHIR

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
chitinase activity	6.40555694403866	bayes_pls_golite062009
hydrolase activity, hydrolyzing O-glycosyl compounds	1.91170236789651	bayes_pls_golite062009
amylase activity	1.38959979746158	bayes_pls_golite062009
hydrolase activity, acting on glycosyl bonds	1.34796838721403	bayes_pls_golite062009
chitin binding	1.29046765706168	bayes_pls_golite062009
binding	0.931465888895274	bayes_pls_golite062009
growth factor activity	0.803631304661827	bayes_pls_golite062009
glucosidase activity	0.766503513427695	bayes_pls_golite062009
receptor binding	0.607116029438976	bayes_pls_golite062009
catalytic activity	0.534516847146079	bayes_pls_golite062009
carbohydrate binding	0.4998423581103	bayes_pls_golite062009
transferase activity, transferring hexosyl groups	0.266938437560648	bayes_pls_golite062009
hydrolase activity	0.178746202646272	bayes_pls_golite062009

Predicted Domain #2

Region A: Residues: [70-76]	1 11 21 31 41 51 \| \| \| \| \| \| 1 DEAFISG [Run NCBI BLAST on this sequence.]
Region B: Residues: [280-295]	1 11 21 31 41 51 \| \| \| \| \| \| 1 ITEIDQYVDY WNMMTY [Run NCBI BLAST on this sequence.]
Region C: Residues: [320-342]	1 11 21 31 41 51 \| \| \| \| \| \| 1 NFAMHYMIDR FGVNSRKLVL GMA [Run NCBI BLAST on this sequence.]
Region D: Residues: [427-480]	1 11 21 31 41 51 \| \| \| \| \| \| 1 KSVKTKAEYV THNNLGGGFW WESCGEAYAN ESRSLINAFN EGLHFNVSSK PSIF [Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	616.228787
Match:	1d2kA_
Description:	Chitinase 1
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A: Residues: [77-279]	1 11 21 31 41 51 \| \| \| \| \| \| 1 VYYSNWSPYK PRFHFPHDIN LKQVSHIYYA FFKINSRTGG IENTDSWSDL EMNLYKSLAI 60 61 KNSELIKESS NNSVQNILPL GCIGELFYLK NTCSDKKFKV IMSIGGWSDS ENFKIIIKDD 120 121 KLLQNFVDSS VETMFRLGFD GIDLDWEFPG NNESEPRGYL KLVRMLRLKL NSLESQIFGK 180 181 RTEDHFQLSI AAPAFKDKLF YLP [Run NCBI BLAST on this sequence.]
Region B: Residues: [296-319]	1 11 21 31 41 51 \| \| \| \| \| \| 1 DYYGSWSETT GYHSNLFSET ELNG [Run NCBI BLAST on this sequence.]
Region C: Residues: [343-426]	1 11 21 31 41 51 \| \| \| \| \| \| 1 AYGRSFHIKD NKFEPFNQNT VLINKIFKGV GKPTKEIDKA DGKEGIWPYK NLPKIGTIEQ 60 61 YDPKYVSAYC FDEKNSIFIS YDNT [Run NCBI BLAST on this sequence.]
Region D: Residues: [481-511]	1 11 21 31 41 51 \| \| \| \| \| \| 1 QDVRVKKYYL NKYGDGGFLS PYLKHLDSRK Q [Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	616.228787
Match:	1d2kA_
Description:	Chitinase 1
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: