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View Structure Prediction Details

Protein: PEX5
Organism: Saccharomyces cerevisiae
Length: 612 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PEX5.

Description E-value Query
Range
Subject
Range
PEX5 - Peroxisomal membrane signal receptor for the C-terminal tripeptide signal sequence (PTS1) of peroxis...
PEX5_YEAST - Peroxisomal targeting signal receptor OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PE...
7.0E-98 [1..612] [1..612]
ogt-1 - status:Confirmed UniProt:O18158 protein_id:AAA62535.2
6.0E-80 [34..584] [15..597]
gi|13775066 - gi|13775066|gb|AAK39123.1|AF363030_1 UDP-N-acetylglucosaminyltransferase [Mus musculus]
2.0E-79 [166..593] [83..502]
gi|5052534 - gi|5052534|gb|AAD38597.1|AF145622_1 BcDNA.GH04245 [Drosophila melanogaster]
3.0E-79 [61..570] [3..503]
OGT1_RAT - UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit OS=Rattus norvegicu...
1.0E-78 [115..593] [12..492]
OGT - O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylgluco...
gi|123993895, gi... - gi|224487755|dbj|BAH24112.1| O-linked N-acetylglucosamine (GlcNAc) transferase [synthetic construct]...
2.0E-78 [115..593] [12..492]
gi|15823781 - gi|15823781|dbj|BAB69071.1| short form of PTS1-receptor [Cricetulus griseus]
5.0E-74 [4..610] [9..599]

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Predicted Domain #1
Region A:
Residues: [1-195]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDVGSCSVGN NPLAQLHKHT QQNKSLQFNQ KNNGRLNESP LQGTNKPGIS EAFISNVNAI  60
   61 SQENMANMQR FINGEPLIDD KRRMEIGPSS GRLPPFSNVH SLQTSANPTQ IKGVNDISHW 120
  121 SQEFQGSNSI QNRNADTGNS EKAWQRGSTT ASSRFQYPNT MMNNYAYASM NSLSGSRLQS 180
  181 PAFMNQQQSG RSKEG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [196-395]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VNEQEQQPWT DQFEKLEKEV SENLDINDEI EKEENVSEVE QNKPETVEKE EGVYGDQYQS  60
   61 DFQEVWDSIH KDAEEVLPSE LVNDDLNLGE DYLKYLGGRV NGNIEYAFQS NNEYFNNPNA 120
  121 YKIGCLLMEN GAKLSEAALA FEAAVKEKPD HVDAWLRLGL VQTQNEKELN GISALEECLK 180
  181 LDPKNLEAMK TLAISYINEG 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 525.221849
Match: 1fchA_
Description: Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [396-471]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YDMSAFTMLD KWAETKYPEI WSRIKQQDDK FQKEKGFTHI DMNAHITKQF LQLANNLSTI  60
   61 DPEIQLCLGL LFYTKD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 525.221849
Match: 1fchA_
Description: Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peroxisome targeting sequence binding 6.28836842401449 bayes_pls_golite062009
peroxisome matrix targeting signal-1 binding 5.30441166392789 bayes_pls_golite062009
binding 2.14253214573541 bayes_pls_golite062009
protein binding 1.83529176977066 bayes_pls_golite062009
signal sequence binding 1.13935627118933 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [472-531]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DFDKTIDCFE SALRVNPNDE LMWNRLGASL ANSNRSEEAI QAYHRALQLK PSFVRARYNL  60
   61 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 525.221849
Match: 1fchA_
Description: Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [532-612]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AVSSMNIGCF KEAAGYLLSV LSMHEVNTNN KKGDVGSLLN TYNDTVIETL KRVFIAMNRD  60
   61 DLLQEVKPGM DLKRFKGEFS F

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 525.221849
Match: 1fchA_
Description: Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle