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View Structure Prediction Details

Protein: DNF2
Organism: Saccharomyces cerevisiae
Length: 1612 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DNF2.

Description E-value Query
Range		 Subject
Range
DNF2 - Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contribute...
ATC4_YEAST - Phospholipid-transporting ATPase DNF2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DN...
 0.0 [1..1612] [1..1612]
SPAC24B11.12c - P-type ATPase
ATCX_SCHPO - Putative phospholipid-transporting ATPase C24B11.12c OS=Schizosaccharomyces pombe (strain 972 / ATCC...
 0.0 [191..1520] [47..1363]
gi|11994361 - gi|11994361|dbj|BAB02320.1| P-type transporting ATPase-like protein [Arabidopsis thaliana]
 0.0 [308..1511] [32..1234]
ATP8A1 - ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
 0.0 [302..1524] [5..1160]
AT8A2_MOUSE - Phospholipid-transporting ATPase IB OS=Mus musculus GN=Atp8a2 PE=1 SV=1
 0.0 [344..1528] [21..1148]

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Predicted Domain #1
Region A:
Residues: [1-172] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSPSKPTSP FVDDIEHESG SASNGLSSMS PFDDSFQFEK PSSAHGNIEV AKTGGSVLKR  60
   61 QSKPMKDIST PDLSKVTFDG IDDYSNDNDI NDDDELNGKK TEIHEHENEV DDDLHSFQAT 120
  121 PMPNTGGFED VELDNNEGSN NDSQADHKLK RVRFGTRRNK SGRIDINRSK TL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [173-319] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KWAKKNFHNA IDEFSTKEDS LENSALQNRS DELRTVYYNL PLPEDMLDED GLPLAVYPRN  60
   61 KIRTTKYTPL TFFPKNILFQ FHNFANIYFL ILLILGAFQI FGVTNPGFAS VPLIVIVIIT 120
  121 AIKDGIEDSR RTVLDLEVNN TRTHILS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.709 0.832 intracellular protein transport a.47.2 t-snare proteins

Predicted Domain #3
Region A:
Residues: [320-358] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GVKNENVAVD NVSLWRRFKK ANTRALIKIF EYFSENLTA

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [428-584] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RTLQPNPECR FAKDYWKNVK VGDIVRVHNN DEIPADMILL STSDVDGACY VETKNLDGET  60
   61 NLKVRQSLKC SKIIKSSRDI TRTKFWVESE GPHANLYSYQ GNFKWQDTQN GNIRNEPVNI 120
  121 NNLLLRGCTL RNTKWAMGMV IFTGDDTKIM INAGVTP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1000.0
Match: 1eulA_
Description: Calcium ATPase, transduction domain A; Calcium ATPase, catalytic domain P; Calcium ATPase; Calcium ATPase, transmembrane domain M

Predicted Domain #4
Region A:
Residues: [359-419] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AGREKKLQKK REELRRKRNS RSFGPRGSLD SIGSYRMSAD FGRPSLDYEN LNQTMSQANR  60
   61 Y

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [585-669] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TKKSRISREL NFSVILNFVL LFILCFTAGI VNGVYYKQKP RSRDYFEFGT IGGSASTNGF  60
   61 VSFWVAVILY QSLVPISLYI SVEII

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [1177-1460] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DVAMIQSADV GVGIAGEEGR QAVMCSDYAI GQFRYVTRLV LVHGKWCYKR LAEMIPQFFY  60
   61 KNVIFTLSLF WYGIYNNFDG SYLFEYTYLT FYNLAFTSVP VILLAVLDQD VSDTVSMLVP 120
  121 QLYRVGILRK EWNQTKFLWY MLDGVYQSVI CFFFPYLAYH KNMVVTENGL GLDHRYFVGV 180
  181 FVTAIAVTSC NFYVFMEQYR WDWFCGLFIC LSLAVFYGWT GIWTSSSSSN EFYKGAARVF 240
  241 AQPAYWAVLF VGVLFCLLPR FTIDCIRKIF YPKDIEIVRE MWLR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1000.0
Match: 1eulA_
Description: Calcium ATPase, transduction domain A; Calcium ATPase, catalytic domain P; Calcium ATPase; Calcium ATPase, transmembrane domain M

Predicted Domain #5
Region A:
Residues: [420-427] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NDGENLVD

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [670-719] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KTAQAIFIYT DVLLYNAKLD YPCTPKSWNI SDDLGQIEYI FSDKTGTLTQ

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [1010-1176] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LQDGVPDSIA LLAEAGIKLW VLTGDKVETA INIGFSCNVL NNDMELLVVK ASGEDVEEFG  60
   61 SDPIQVVNNL VTKYLREKFG MSGSEEELKE AKREHGLPQG NFAVIIDGDA LKVALNGEEM 120
  121 RRKFLLLCKN CKAVLCCRVS PAQKAAVVKL VKKTLDVMTL AIGDGSN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1000.0
Match: 1eulA_
Description: Calcium ATPase, transduction domain A; Calcium ATPase, catalytic domain P; Calcium ATPase; Calcium ATPase, transmembrane domain M

Predicted Domain #6
Region A:
Residues: [720-1009] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NVMEFKKCTI NGVSYGRAYT EALAGLRKRQ GVDVESEGRR EKEEIAKDRE TMIDELRSMS  60
   61 DNTQFCPEDL TFVSKEIVED LKGSSGDHQQ KCCEHFLLAL ALCHSVLVEP NKDDPKKLDI 120
  121 KAQSPDESAL VSTARQLGYS FVGSSKSGLI VEIQGVQKEF QVLNVLEFNS SRKRMSCIIK 180
  181 IPGSTPKDEP KALLICKGAD SVIYSRLDRT QNDATLLEKT ALHLEEYATE GLRTLCLAQR 240
  241 ELTWSEYERW VKTYDVAAAS VTNREEELDK VTDVIERELI LLGGTAIEDR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1000.0
Match: 1eulA_
Description: Calcium ATPase, transduction domain A; Calcium ATPase, catalytic domain P; Calcium ATPase; Calcium ATPase, transmembrane domain M

Predicted Domain #7
Region A:
Residues: [1461-1612] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GDFDLYPQGY DPTDPSRPRI NEIRPLTDFK EPISLDTHFD GVSHSQETIV TEEIPMSILN  60
   61 GEQGSRKGYR VSTTLERRDQ LSPVTTTNNL PRRSMASARG NKLRTSLDRT REEMLANHQL 120
  121 DTRYSVERAR ASLDLPGINH AETLLSQRSR DR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle