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View Structure Prediction Details

Protein: MAK21
Organism: Saccharomyces cerevisiae
Length: 1025 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MAK21.

Description E-value Query
Range
Subject
Range
MAK21 - Constituent of 66S pre-ribosomal particles, required for large (60S) ribosomal subunit biogenesis; i...
MAK21_YEAST - Ribosome biogenesis protein MAK21 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MAK21 ...
0.0 [1..1025] [1..1025]
CBF_MOUSE, CEBPZ... - (P53569) CCAAT/enhancer-binding protein zeta (CCAAT-box-binding transcription factor) (CCAAT-binding...
0.0 [29..968] [17..933]
SPAC4F10.09c - ribosome biogenesis protein Noc1
YEK9_SCHPO - Uncharacterized protein C4F10.09c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAC4F10...
0.0 [174..1021] [2..859]
NOC3L_CRIGR - Nucleolar complex protein 3 homolog OS=Cricetulus griseus GN=NOC3L PE=2 SV=1
0.0 [39..856] [1..793]
CE09599 - CCAAT binding factor 1 protein like status:Confirmed UniProt:Q19753 protein_id:CAB01168.1
0.0 [123..908] [11..796]
gi|25350651, gi|... - pir||E96748 hypothetical protein T10D10.9 [imported] - Arabidopsis thaliana, gi|15218492|ref|NP_177...
0.0 [82..701] [2..636]
NOC4L - nucleolar complex associated 4 homolog (S. cerevisiae)
gi|123983406, gi... - gi|123998109|gb|ABM86656.1| nucleolar complex associated 4 homolog (S. cerevisiae) [synthetic constr...
0.0 [303..805] [16..499]

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Predicted Domain #1
Region A:
Residues: [1-213]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSENNGNPLD LSSLRNKISS KLRDNNSKKA KKTHKGKDVK ASSNSKKVNE DIRREALALG  60
   61 ASEEDLKLIQ GLSDDDDAKS EQEFDAVADE DADDKGFKND LQNFMKNVGF DQHKLEDVDD 120
  121 DDIEEESTSS KESKIPAQEK EHAQSNIASS TIEKTSQESI DNGSEQEENT VEEANLSSDQ 180
  181 EPESESAEKE KKEEKDGGLI TQTTIISSDK LII

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [214-922]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PYDKPWYEIP LDPQVGQNDD VEELSKEQIE KLFERGKQTL EADNQTYYEE FTKDSSQAKF  60
   61 MSQILSDGTL NDKISAVTLL IQDSPLHNTK SLETLVSYCG KKSRNSALQS LNALKDLFLN 120
  121 GLLPNRKLRY FKNQPGLSMM LNKKTLAIFY FEDYLKKLFF RVLEVLEVLS HDPIIHVRLQ 180
  181 ILNHVFDLLT NQPEQEFNLL RLGVNKIGDI DSKVSSKASY LLLKLEQAHP NMKSIVIDAI 240
  241 VDIALRPNAD YHTTYYSVIT LNQTILKRSE DSVANKLVKT YFTLFEKFLI NTDKDNTNGV 300
  301 VKSNSKSYEE KRKKNFKKGK HGGKSVKIEK TENEVLDEKN SKLFSALLTG INRAFPFAQI 360
  361 PASVYEVHME TLFKITHSSN FNTSIQALVL INQVTVKAKL NSDRYYRTLY ESLFDPRLVN 420
  421 SSKQGIYLNL LYKSLKQDAL NVERVEAFVK RILQVCSHWL NVGTITGFFF LLIQLAKTVP 480
  481 QIKNLLTNTP VDYEYESDAE EEQGDKDIKR KEYDGRKRDP KFANAEKSSL WEINNFINHF 540
  541 HPTVKTYANA YVTGETEQIA KPDLGLFTLS HFLDRFVYRS AKQTNTARGT SIMQPLFSGS 600
  601 RVNDSVLVKA SDIMHDQGPV NTEDWLTKKV EDIKPEDKFF YQYFTTKKTA DGKGKKSNKA 660
  661 SNFDSDDEMD ENEIWSALVK SRPDVEDDSD DSELDFAEDD FSDSTSDDE

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 1000.0
Match: PF03914
Description: CBF/Mak21 family

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted functions:

Term Confidence Notes
binding 2.81296846555705 bayes_pls_golite062009
RNA binding 2.62914297393378 bayes_pls_golite062009
structural molecule activity 2.41912877876968 bayes_pls_golite062009
protein binding 1.81870125631028 bayes_pls_golite062009
mRNA binding 0.868658457661827 bayes_pls_golite062009
cytoskeletal protein binding 0.19418057335311 bayes_pls_golite062009
nucleic acid binding 0.118461769548431 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [923-1025]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PKLDAIDDED AKSEGSQESD QEEGLDEDIF YSFDGEQDNS DKKRSFAESS EEDESSEEEK  60
   61 EEEENKEVSA KRAKKKQRKN MLKSLPVFAS ADDYAQYLDQ DSD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.532 a.118.1 ARM repeat
View Download 0.509 a.29.2 Bromodomain
View Download 0.499 a.24.4 Hemerythrin
View Download 0.536 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.497 a.7.6 Ribosomal protein S20
View Download 0.441 a.24.17 Group V grass pollen allergen
View Download 0.397 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.387 a.7.1 Spectrin repeat
View Download 0.369 a.29.4 RecG, N-terminal domain
View Download 0.353 a.61.1 Retroviral matrix proteins
View Download 0.348 d.15.4 2Fe-2S ferredoxin-like
View Download 0.326 a.24.3 Cytochromes
View Download 0.324 a.121.1 Tetracyclin repressor-like, C-terminal domain
View Download 0.318 i.1.1 Ribosome and ribosomal fragments
View Download 0.311 a.64.1 Saposin
View Download 0.304 a.24.7 FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
View Download 0.293 a.3.1 Cytochrome c
View Download 0.266 a.126.1 Serum albumin-like
View Download 0.261 a.26.1 4-helical cytokines
View Download 0.252 a.79.1 Antitermination factor NusB
View Download 0.244 a.24.11 Bacterial GAP domain
View Download 0.233 a.130.1 Chorismate mutase II
View Download 0.227 a.39.2 Insect pheromon/odorant-binding proteins
View Download 0.217 a.118.8 TPR-like
View Download 0.215 d.54.1 Enolase N-terminal domain-like
View Download 0.214 a.4.1 Homeodomain-like
View Download 0.211 i.11.1 Computational models partly based on NMR data
View Download 0.207 a.36.1 Signal peptide-binding domain
View Download 0.206 a.1.1 Globin-like
View Download 0.203 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.202 a.91.1 Regulator of G-protein signalling, RGS


YRC Informatics Platform - Version 3.0
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