YRC Public Data Repository - Protein Structure Prediction

Protein:	HEM13
Organism:	Saccharomyces cerevisiae
Length:	328 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HEM13.

Description	E-value	Query Range	Subject Range
gi\|171316 - gi\|171316\|gb\|AAA34529.1\| coproporphyrinogen oxidase (EC 1.3.3.3)	0.0	[1..328]	[1..328]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[5..327]	[72..385]
HEM6_SOYBN - Oxygen-dependent coproporphyrinogen-III oxidase, chloroplastic OS=Glycine max GN=CPX PE=2 SV=1	0.0	[5..327]	[72..385]
HEM61_ARATH - Coproporphyrinogen-III oxidase 1, chloroplastic OS=Arabidopsis thaliana GN=CPX1 PE=2 SV=1	0.0	[7..327]	[75..386]
gi\|158280948, gi... - gi\|4731370\|gb\|AAD28475.1\|AF133672_1 coproporphyrinogen III oxidase precursor [Chlamydomonas reinhard...	0.0	[3..327]	[50..365]
gi\|18376156 - gi\|18376156\|emb\|CAD21231.1\| probable coproporphyrinogen oxidase precursor [Neurospora crassa] gi\|164428005, gi... - gi\|164428005\|ref\|XP_956249.2\| coproporphyrinogen III oxidase [Neurospora crassa OR74A], gi\|157071970...	0.0	[7..327]	[94..409]
Coprox-PA, FBpp0... - The gene Coproporphyrinogen oxidase is referred to in FlyBase by the symbol Dmel\Coprox (CG3433, FBg... gi\|220953578, gi... - gi\|220953578\|gb\|ACL89332.1\| Coprox-PA [synthetic construct], gi\|220943608\|gb\|ACL84347.1\| Coprox-PA [...	0.0	[12..327]	[85..390]
HEM6_TOBAC - Oxygen-dependent coproporphyrinogen-III oxidase, chloroplastic OS=Nicotiana tabacum GN=CPX PE=2 SV=1	0.0	[6..327]	[84..397]

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Predicted Domain #1

Region A:
Residues: [1-328]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPAPQDPRNL PIRQQMEALI RRKQAEITQG LESIDTVKFH ADTWTRGNDG GGGTSMVIQD  60
   61 GTTFEKGGVN VSVVYGQLSP AAVSAMKADH KNLRLPEDPK TGLPVTDGVK FFACGLSMVI 120
  121 HPVNPHAPTT HLNYRYFETW NQDGTPQTWW FGGGADLTPS YLYEEDGQLF HQLHKDALDK 180
  181 HDTALYPRFK KWCDEYFYIT HRKETRGIGG IFFDDYDERD PQEILKMVED CFDAFLPSYL 240
  241 TIVKRRKDMP YTKEEQQWQA IRRGRYVEFN LIYDRGTQFG LRTPGSRVES ILMSLPEHAS 300
  301 WLYNHHPAPG SREAKLLEVT TKPREWVK

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	265.283997
Match:	PF01218
Description:	Coproporphyrinogen III oxidase

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
coproporphyrinogen oxidase activity	5.81247465629978	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor	5.1724965213902	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors	3.24343461428814	bayes_pls_golite062009
binding	1.8297496024321	bayes_pls_golite062009
catalytic activity	1.56559069221062	bayes_pls_golite062009
protein binding	0.374996803717649	bayes_pls_golite062009
oxidoreductase activity	0.0360049460478797	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: