YRC Public Data Repository - Protein Structure Prediction

Protein:	ARO3
Organism:	Saccharomyces cerevisiae
Length:	370 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ARO3.

Description	E-value	Query Range	Subject Range
AROF_YEAST - Phospho-2-dehydro-3-deoxyheptonate aldolase, phenylalanine-inhibited OS=Saccharomyces cerevisiae (st... gi\|151942027 - gi\|151942027\|gb\|EDN60383.1\| 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase isoenzyme [S... ARO3 - 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic am... gi\|207346828 - gi\|207346828\|gb\|EDZ73205.1\| YDR035Wp-like protein [Saccharomyces cerevisiae AWRI1631] gi\|190404992 - gi\|190404992\|gb\|EDV08259.1\| 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase isoenzyme [Saccharo...	0.0	[1..370]	[1..370]
gi\|11527262 - gi\|11527262\|gb\|AAG36950.1\|AF283009_1 phe-inhibited DAHP synthase [Aspergillus nidulans]	0.0	[2..367]	[5..369]
AROG_ECO57 - Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive OS=Escherichia coli O157:H7 GN=aroG PE=3 ... gi\|238859808, gi... - gi\|238900012\|ref\|YP_002925808.1\| 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, phenylalanine... EG10079 - 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, phenylalanine repressible / 3-deoxy-D-arabino-... gi\|242376509, gi... - gi\|251784236\|ref\|YP_002998540.1\| hypothetical protein B21_00696 [Escherichia coli BL21], gi\|24237650... gi\|15800463, gi\|... - gi\|15800463\|ref\|NP_286475.1\| phospho-2-dehydro-3-deoxyheptonate aldolase [Escherichia coli O157:H7 E... gi\|253976912, gi... - gi\|254287605\|ref\|YP_003053353.1\| 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, phenylalanine... AROG_ECOLI - Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive (EC 2.5.1.54) (Phospho-2-keto-3-deoxyhept... gi\|253972718, gi... - gi\|254160817\|ref\|YP_003043925.1\| 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, phenylalanine... gi\|254591304, gi... - gi\|254791904\|ref\|YP_003076741.1\| 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, phenylalanine... gi\|168750246, gi... - gi\|188015532\|gb\|EDU53654.1\| 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive [Escherichia coli O... gi\|1651339, gi\|8... - gi\|89107605\|ref\|AP_001385.1\| 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, phenylalanine rep... gi\|13360241, gi\|... - gi\|15830036\|ref\|NP_308809.1\| phospho-2-dehydro-3-deoxyheptonate aldolase [Escherichia coli O157:H7 s... gi\|168763344, gi... - gi\|189366448\|gb\|EDU84864.1\| 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive [Escherichia coli O... gi\|168757043, gi... - gi\|189355850\|gb\|EDU74269.1\| 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive [Escherichia coli O... gi\|187768162, gi... - gi\|187768162\|gb\|EDU32006.1\| 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive [Escherichia coli O... gi\|189363458, gi... - gi\|189363458\|gb\|EDU81877.1\| 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive [Escherichia coli O... gi\|189373159, gi... - gi\|189373159\|gb\|EDU91575.1\| 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive [Escherichia coli O... gi\|168779242, gi... - gi\|189002923\|gb\|EDU71909.1\| 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive [Escherichia coli O... gi\|81240176, gi\|... - gi\|82776028\|ref\|YP_402375.1\| phospho-2-dehydro-3-deoxyheptonate aldolase [Shigella dysenteriae Sd197... gi\|217326155, gi... - gi\|217326155\|ref\|ZP_03442239.1\| 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive [Escherichia co... EG10079 - 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, phenylalanine repressible / 3-deoxy-D-arabino-... gi\|81244585, gi\|... - gi\|82543174\|ref\|YP_407121.1\| phospho-2-dehydro-3-deoxyheptonate aldolase [Shigella boydii Sb227], gi... gi\|209917998, gi... - gi\|209917998\|ref\|YP_002292082.1\| phospho-2-dehydro-3-deoxyheptonate aldolase [Escherichia coli SE11]... gi\|192926766, gi... - gi\|75256338\|ref\|ZP_00728008.1\| COG0722: 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase ... gi\|75511356, gi\|... - gi\|75511356\|ref\|ZP_00734041.1\| COG0722: 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase ... gi\|218694171, gi... - gi\|218694171\|ref\|YP_002401838.1\| phospho-2-dehydro-3-deoxyheptonate aldolase [Escherichia coli 55989... gi\|170020908, gi... - gi\|170020908\|ref\|YP_001725862.1\| phospho-2-dehydro-3-deoxyheptonate aldolase [Escherichia coli ATCC ... gi\|83584861, gi\|... - gi\|83584861\|ref\|ZP_00923520.1\| COG0722: 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase ... gi\|168800814, gi... - gi\|189376981\|gb\|EDU95397.1\| 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive [Escherichia coli O... gi\|195936742 - gi\|195936742\|ref\|ZP_03082124.1\| phospho-2-dehydro-3-deoxyheptonate aldolase [Escherichia coli O157:H... gi\|170080414, gi... - gi\|170080414\|ref\|YP_001729734.1\| 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, phenylalanine... gi\|194412266, gi... - gi\|75209077\|ref\|ZP_00709335.1\| COG0722: 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase ... gi\|208731490, gi... - gi\|208814842\|ref\|ZP_03256021.1\| 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive [Escherichia co... gi\|75228379, gi\|... - gi\|75228379\|ref\|ZP_00715027.1\| COG0722: 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase ... gi\|208808417, gi... - gi\|208808417\|ref\|ZP_03250754.1\| 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive [Escherichia co... gi\|187427742, gi... - gi\|75175250\|ref\|ZP_00695560.1\| COG0722: 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase ... gi\|124531871, gi... - gi\|124531871\|ref\|ZP_01701970.1\| phospho-2-dehydro-3-deoxyheptonate aldolase [Escherichia coli B], gi... gi\|209400570, gi... - gi\|209400570\|ref\|YP_002269381.1\| 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive [Escherichia c... gi\|75194907, gi\|... - gi\|75194907\|ref\|ZP_00704977.1\| COG0722: 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase ... gi\|208737562, gi... - gi\|208822077\|ref\|ZP_03262396.1\| 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive [Escherichia co...	0.0	[10..365]	[1..349]
gi\|205327720, gi... - gi\|205327720\|gb\|EDZ14484.1\| 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive [Salmonella enteric... gi\|197290090, gi... - gi\|197290090\|gb\|EDY29447.1\| 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive [Salmonella enteric... gi\|161364372, gi... - gi\|161615008\|ref\|YP_001588973.1\| phospho-2-dehydro-3-deoxyheptonate aldolase [Salmonella enterica su... lcl\|NC_016856.1_... - [gene=aroG] [protein=phospho-2-dehydro-3-deoxyheptonate aldolase] [protein_id=YP_005236479.2] [locat... gi\|199602771, gi... - gi\|200390326\|ref\|ZP_03216937.1\| 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive [Salmonella ent... gi\|194734297, gi... - gi\|194734297\|ref\|YP_002113862.1\| 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive [Salmonella en... gi\|16764125, gi\|... - gi\|16764125\|ref\|NP_459740.1\| phospho-2-dehydro-3-deoxyheptonate aldolase [Salmonella typhimurium LT2... gi\|197248245, gi... - gi\|197248245\|ref\|YP_002145716.1\| 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive [Salmonella en...	0.0	[10..365]	[1..349]
gi\|224467101, gi... - gi\|224582574\|ref\|YP_002636372.1\| 3-deoxy-7-phosphoheptulonate synthase [Salmonella enterica subsp. e... gi\|213649740 - gi\|213649740\|ref\|ZP_03379793.1\| phospho-2-dehydro-3-deoxyheptonate aldolase [Salmonella enterica sub... gi\|197264402, gi... - gi\|197264402\|ref\|ZP_03164476.1\| 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive [Salmonella ent... gi\|194470112, gi... - gi\|194470112\|ref\|ZP_03076096.1\| 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive [Salmonella ent... gi\|194447367, gi... - gi\|194447367\|ref\|YP_002044789.1\| phospho-2-dehydro-3-deoxyheptonate aldolase [Salmonella enterica su... gi\|194404569, gi... - gi\|194445906\|ref\|YP_002039996.1\| 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive [Salmonella en... gi\|213427703 - gi\|213427703\|ref\|ZP_03360453.1\| phospho-2-dehydro-3-deoxyheptonate aldolase [Salmonella enterica sub... gi\|213163244 - gi\|213163244\|ref\|ZP_03348954.1\| phospho-2-dehydro-3-deoxyheptonate aldolase [Salmonella enterica sub... gi\|206708002, gi... - gi\|207856199\|ref\|YP_002242850.1\| phospho-2-dehydro-3-deoxyheptonate aldolase [Salmonella enterica su... gi\|197939792, gi... - gi\|198245276\|ref\|YP_002214725.1\| 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive [Salmonella en... gi\|205334730, gi... - gi\|205334730\|gb\|EDZ21494.1\| 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive [Salmonella enteric... gi\|205324476, gi... - gi\|205324476\|gb\|EDZ12315.1\| 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive [Salmonella enteric... gi\|162139602 - gi\|162139602\|ref\|YP_215746.2\| phospho-2-dehydro-3-deoxyheptonate aldolase [Salmonella enterica subsp... gi\|29138164, gi\|... - gi\|29142533\|ref\|NP_805875.1\| phospho-2-dehydro-3-deoxyheptonate aldolase [Salmonella enterica subsp.... gi\|205343148, gi... - gi\|205343148\|gb\|EDZ29912.1\| 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive [Salmonella enteric... gi\|16759694 - gi\|16759694\|ref\|NP_455311.1\| phospho-2-dehydro-3-deoxyheptonate aldolase [Salmonella enterica subsp.... gi\|168468100, gi... - gi\|195628821\|gb\|EDX48243.1\| 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive [Salmonella enteric... gi\|205347179, gi... - gi\|205347179\|gb\|EDZ33810.1\| 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive [Salmonella enteric... gi\|25291146, gi\|... - gi\|25291146\|pir\|\|AG0593 phospho-2-dehydro-3-deoxyheptonate aldolase (DAHP synthetase) phenylalanine ... gi\|168240614, gi... - gi\|205340111\|gb\|EDZ26875.1\| 3-deoxy-7-phosphoheptulonate synthase, Phe-sensitive [Salmonella enteric...	0.0	[10..365]	[1..349]
gi\|17427754 - gi\|17427754\|emb\|CAD14273.1\| probable phospho-2-dehydro-3-deoxyheptonate aldolase, phe-sensitive (dah... gi\|17545462 - gi\|17545462\|ref\|NP_518864.1\| phospho-2-dehydro-3-deoxyheptonate aldolase [Ralstonia solanacearum GMI...	0.0	[4..366]	[35..391]
AROF_CANAX - Phospho-2-dehydro-3-deoxyheptonate aldolase, phenylalanine-inhibited OS=Candida albicans GN=ARO3 PE=...	0.0	[1..367]	[1..368]
SPAC24H6.10c - phospho-2-dehydro-3-deoxyheptonate aldolase AROF_SCHPO - Putative phospho-2-dehydro-3-deoxyheptonate aldolase OS=Schizosaccharomyces pombe (strain 972 / ATCC...	0.0	[3..366]	[8..367]
gi\|12720830, gi\|... - gi\|15602428\|ref\|NP_245500.1\| phospho-2-dehydro-3-deoxyheptonate aldolase [Pasteurella multocida subs...	0.0	[15..369]	[13..361]

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Predicted Domain #1

Region A:
Residues: [1-370]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFIKNDHAGD RKRLEDWRIK GYDPLTPPDL LQHEFPISAK GEENIIKARD SVCDILNGKD  60
   61 DRLVIVIGPC SLHDPKAAYD YADRLAKISE KLSKDLLIIM RAYLEKPRTT VGWKGLINDP 120
  121 DMNNSFQINK GLRISREMFI KLVEKLPIAG EMLDTISPQF LSDCFSLGAI GARTTESQLH 180
  181 RELASGLSFP IGFKNGTDGG LQVAIDAMRA AAHEHYFLSV TKPGVTAIVG TEGNKDTFLI 240
  241 LRGGKNGTNF DKESVQNTKK QLEKAGLTDD SQKRIMIDCS HGNSNKDFKN QPKVAKCIYD 300
  301 QLTEGENSLC GVMIESNINE GRQDIPKEGG REGLKYGCSV TDACIGWEST EQVLELLAEG 360
  361 VRNRRKALKK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1145.0
Match:	1gg1A_
Description:	3-deoxy-D-arabino-heptulosonate-7-phosphate synthase (DAHP synthase, AroG)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
3-deoxy-7-phosphoheptulonate synthase activity	2.72022882819661	bayes_pls_golite062009
catalytic activity	2.67031204377352	bayes_pls_golite062009
lyase activity	0.740424046054758	bayes_pls_golite062009
transferase activity, transferring aldehyde or ketonic groups	0.719960432098845	bayes_pls_golite062009
oxo-acid-lyase activity	0.606352769346285	bayes_pls_golite062009
ligase activity, forming carbon-carbon bonds	0.490222900376021	bayes_pls_golite062009
transferase activity	0.464721888799972	bayes_pls_golite062009
carbon-carbon lyase activity	0.36754360512349	bayes_pls_golite062009
3-deoxy-8-phosphooctulonate synthase activity	0.0356008407895519	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: