YRC Public Data Repository - Protein Structure Prediction

Protein:	MPH2
Organism:	Saccharomyces cerevisiae
Length:	609 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MPH2.

Description	E-value	Query Range	Subject Range
MPH2 - Alpha-glucoside permease, transports maltose, maltotriose, alpha-methylglucoside, and turanose; iden... MPH2_YEAST - Alpha-glucosides permease MPH2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MPH2 PE=2...	0.0	[1..609]	[1..609]
KHT2_KLULC - Hexose transporter 2 OS=Kluyveromyces lactis GN=KHT2 PE=3 SV=1	0.0	[54..582]	[16..547]
STC_RICCO - Sugar carrier protein C OS=Ricinus communis GN=STC PE=2 SV=1	0.0	[84..576]	[12..507]
gi\|115470211, gi... - gi\|50508995\|dbj\|BAD31944.1\| putative monosaccharide transport protein MST1 [Oryza sativa Japonica Gr... gi\|125556956 - gi\|125556956\|gb\|EAZ02492.1\| hypothetical protein OsI_24597 [Oryza sativa Indica Group] gi\|11991114 - gi\|11991114\|dbj\|BAB19864.1\| monosaccharide transporter 3 [Oryza sativa]	0.0	[89..569]	[15..498]

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Predicted Domain #1

Region A:
Residues: [1-68]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKNLSFLINR RKENTSDSNV YPGKAKSHEP SWIEMDDQTK KDGLDIVHVE FSPDTRAPSD  60
   61 SNKVITEI

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.366	0.890	carbohydrate transport	a.4.5	"Winged helix" DNA-binding domain

Predicted Domain #2

Region A:
Residues: [69-291]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FDATEDAKEA DESERGMPLA TALNTYPKAA AWSLLVSTTL IMEGYDTAIL GAFYALPIFQ  60
   61 RKFGSQNDKT GEWEISASWQ IGLTLCYMAG EIVGLQLTGP SVDLVGNRYT LIIALFFLAA 120
  121 FTFILYFCNS LGMIAVGQAL CGMPWGCFQC LTVSYASEIC PLALRYYLTT YSNLCWLFGQ 180
  181 LFAAGIMKNS QKKYADSELG YKLPFALQWI LPVPLALGIF FAP

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [344-549]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKEGSYSDCF EDKINRRRTR ITCLCWAGQA TCGSILIGYS TYFYEKAGVS TEMSFTFSII  60
   61 QYCLGICATF LSWWASKYFG RYDLYAFGLA FQTIVFFIIG GLGCSSTHGS KMGSGSLLMA 120
  121 VAFFYNLGIA PVVFCLVSEM PSSRLRTKTI ILARNTYNVV SIICSVLILY QLNSKKWNWG 180
  181 AKSGFFWGVL CFCTLIWAVV DLPETA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	194.0103
Match:	1ja5A_
Description:	No description for 1ja5A_ was found.

Predicted functions:

Term	Confidence	Notes
transporter activity	4.09176719149278	bayes_pls_golite062009
substrate-specific transporter activity	3.59744164024479	bayes_pls_golite062009
transmembrane transporter activity	3.5865018981083	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	3.54194478414824	bayes_pls_golite062009
hexose phosphate transmembrane transporter activity	3.3746965264994	bayes_pls_golite062009
glucose-6-phosphate transmembrane transporter activity	3.3746965264994	bayes_pls_golite062009
sugar:hydrogen symporter activity	2.99050613058546	bayes_pls_golite062009
cation:sugar symporter activity	2.99050613058546	bayes_pls_golite062009
monosaccharide transmembrane transporter activity	2.63293544825311	bayes_pls_golite062009
carbohydrate transmembrane transporter activity	2.62141276633776	bayes_pls_golite062009
sugar transmembrane transporter activity	2.47557586092261	bayes_pls_golite062009
ion transmembrane transporter activity	2.21266150105753	bayes_pls_golite062009
solute:hydrogen symporter activity	2.10485633822652	bayes_pls_golite062009
cation transmembrane transporter activity	1.79369588808394	bayes_pls_golite062009
active transmembrane transporter activity	1.59419818573076	bayes_pls_golite062009
secondary active transmembrane transporter activity	1.22264637452409	bayes_pls_golite062009
alcohol transmembrane transporter activity	0.924836669821548	bayes_pls_golite062009
polyol transmembrane transporter activity	0.924836669821548	bayes_pls_golite062009
binding	0.873217664940684	bayes_pls_golite062009
glycerol transmembrane transporter activity	0.812001619402678	bayes_pls_golite062009
symporter activity	0.74591237387473	bayes_pls_golite062009
solute:cation symporter activity	0.74591237387473	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [292-343]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ESPWWLVKKG RFDEARRSLR RTLSGKGPEK EILVTLEVDK IKVTIDKEKR LT

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [550-609]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GKTFVEINEL FKLGVSARKF KSTKVDPFVV KTPLKTSLIT TPREISKLPL QRNSNVSHHL  60
   61

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	194.0103
Match:	1ja5A_
Description:	No description for 1ja5A_ was found.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: