YRC Public Data Repository - Protein Structure Prediction

Protein:	GYP7
Organism:	Saccharomyces cerevisiae
Length:	746 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GYP7.

Description	E-value	Query Range	Subject Range
GYP7 - GTPase-activating protein for yeast Rab family members including: Ypt7p (most effective), Ypt1p, Ypt... gi\|190405222 - gi\|190405222\|gb\|EDV08489.1\| GTPase-activating protein GYP7 [Saccharomyces cerevisiae RM11-1a] GYP7_YEAST - GTPase-activating protein GYP7 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GYP7 PE=1...	0.0	[1..746]	[1..746]
gi\|16944459 - gi\|16944459\|emb\|CAC18154.2\| probable GTPase activating protein [Neurospora crassa]	0.0	[10..707]	[83..774]
GYP7_YARLI - GTPase-activating protein GYP7 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=GYP7 PE=3 SV=2 GYP7_YARLI - GTPase-activating protein GYP7 OS=Yarrowia lipolytica GN=GYP7 PE=3 SV=2	0.0	[10..742]	[20..725]
gyp7 - GTPase activating protein Gyp7 GYP7_SCHPO - GTPase-activating protein gyp7 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=gyp7 PE=3 S...	0.0	[4..729]	[31..730]
TBC1D17 - TBC1 domain family, member 17	0.0	[3..716]	[7..605]
gi\|21450327, gi\|... - gi\|21450327\|ref\|NP_659173.1\| TBC1 domain family, member 17 [Mus musculus], gi\|17160868\|gb\|AAH17607.1...	2.0E-96	[3..628]	[7..515]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	3.0E-80	[140..746]	[493..1038]

Back

Predicted Domain #1

Region A:
Residues: [1-250]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKILFCKSK VFLHPTSDAR DNIAGFLLLT LEANKLSHQA ILQYIPESGL STLEISKLLK  60
   61 HEAKVGTCPT STPFVIENSI NFSNLVNTSL GQAFEISLSQ IYCIQFRPPS PNGWYVGSLV 120
  121 IYPLTEQFTG FQPPVLFFHD QLCPSTTDKL KRLRKSMNPF DDSDELYWGG VDLRNKINEL 180
  181 MELKKSNLEP EFWLVNPSLN DLRNFVSKDL LESYNNSKKD TTELATAGVK LNEKFQEWKW 240
  241 NVMSKIADVT

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [251-352]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TKSTNFIDSW LTNNSPIQKS QIDNEYLQKL LNNEKVKQIE QDYDSARVYL ANWSLGVKQE  60
   61 AERYQKQNKL FDSYRNNIFN DLNLTDELSD TEINNALQRQ FP

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [353-570]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LTEAKWNSLW DENDGRLRVT VNEVKDFIFH GGLENDSLRG KVWGFLLEIY PWDSSQDERV  60
   61 QIDQTLAAEY DQLKLTWSKD FLQFDDEDEE EYWNDQLFRI SKDVRRCDRN LEIFQYNTID 120
  121 GLPPPPQQLP ANENNSTSPE SANDESDDAD DGVRNPHLIH LQNILITYNV YNTNLGYVQG 180
  181 MTDLLSPIYV IMKEEWKTFW CFTHFMDIME RNFLRDQS

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [624-632]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HIWENFWTF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	101.0103
Match:	1fkmA_
Description:	Ypt/Rab-GAP domain of gyp1p
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [571-623]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GIHEQMLTLV ELVQLMLPEL SEHLNKCDSG NLFFCFRMLL VWFKREFEME DIM

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	101.0103
Match:	1fkmA_
Description:	Ypt/Rab-GAP domain of gyp1p
Matching Structure (courtesy of the PDB):

Predicted Domain #5

Region A:
Residues: [633-746]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YYSSQFQLFF MLAILQKNSQ AILQHLNQFD QILKFFNELN GKLDWNDLMV RAELLFKKFE  60
   61 KMMHVMERDL QNVSSSSSSS STGVLPCQSE RLTLLLSKKP IIRHEGQRSK NSVK

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.836	0.229	Rab GTPase activator activity	a.21.1	HMG-box

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits