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View Structure Prediction Details

Protein: CWC2
Organism: Saccharomyces cerevisiae
Length: 339 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CWC2.

Description E-value Query
Range		 Subject
Range
CWC2_YEAST - Pre-mRNA-splicing factor CWC2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CWC2 PE=1 ...
gi|151941798 - gi|151941798|gb|EDN60154.1| complexed with cef1p [Saccharomyces cerevisiae YJM789]
CWC2 - Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms...
 3.0E-78 [1..339] [1..339]
PABPC4 - poly(A) binding protein, cytoplasmic 4 (inducible form)
 5.0E-55 [21..329] [60..370]
gi|126540996, gi... - gi|22507391|ref|NP_683717.1| poly(A) binding protein, cytoplasmic 4 isoform 2 [Mus musculus], gi|163...
 6.0E-54 [21..329] [60..370]
PABP1_RAT - Polyadenylate-binding protein 1 OS=Rattus norvegicus GN=Pabpc1 PE=1 SV=1
 7.0E-54 [21..329] [60..370]
gi|13540314 - gi|13540314|gb|AAK29408.1|AF338225_1 embryonic poly(A) binding protein [Xenopus laevis]
 4.0E-53 [5..329] [44..370]
gi|19526272 - gi|19526272|gb|AAL89666.1|AF411956_7 polyA-binding protein [Takifugu rubripes]
 6.0E-53 [23..329] [62..370]
gi|2665654 - gi|2665654|gb|AAB88449.1| polyadenylate binding protein [Petromyzon marinus]
 2.0E-52 [21..329] [60..371]

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Predicted Domain #1
Region A:
Residues: [1-122] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSWRDKSAK VQVKESELPS SIPAQTGLTF NIWYNKWSQG FAGNTRFVSP FALQPQLHSG  60
   61 KTRGDNDGQL FFCLFFAKGM CCLGPKCEYL HHIPDEEDIG KLALRTEVLD CFGREKFADY 120
  121 RE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 31.09691
Match: 3sxlA_
Description: Sex-lethal protein
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [123-224] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DMGGIGSFRK KNKTLYVGGI DGALNSKHLK PAQIESRIRF VFSRLGDIDR IRYVESKNCG  60
   61 FVKFKYQANA EFAKEAMSNQ TLLLPSDKEW DDRREGTGLL VK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.69897
Match: 1ha1__
Description: Nuclear ribonucleoprotein A1 (RNP A1, UP1)
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [225-339] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WANEDPDPAA QKRLQEELKL ESLNMMVHLI NNNTNSAGTE VNNKNNERLD RTFPEASVDN  60
   61 VKKRLLPLDN GMESDDFIEK LKKVKKNISR ENISSKPSVG KLGGPLLDYL SSDED

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.69897
Match: 1ha1__
Description: Nuclear ribonucleoprotein A1 (RNP A1, UP1)
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle