YRC Public Data Repository - Protein Structure Prediction

Protein:	LYS21
Organism:	Saccharomyces cerevisiae
Length:	440 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LYS21.

Description	E-value	Query Range	Subject Range
gi\|89104762, gi\|... - gi\|89104762\|ref\|ZP_01177296.1\| COG0119: Isopropylmalate/homocitrate/citramalate synthases [Yersinia ... LEU1_YERPA - 2-isopropylmalate synthase OS=Yersinia pestis bv. Antiqua (strain Antiqua) GN=leuA PE=3 SV=1 gi\|165992051, gi... - gi\|166008712\|ref\|ZP_02229610.1\| 2-isopropylmalate synthase [Yersinia pestis biovar Antiqua str. E197... LEU1_YERPS - 2-isopropylmalate synthase OS=Yersinia pseudotuberculosis GN=leuA PE=3 SV=1 gi\|165919820, gi... - gi\|165928209\|ref\|ZP_02224041.1\| 2-isopropylmalate synthase [Yersinia pestis biovar Orientalis str. F... gi\|167049327, gi... - gi\|167401302\|ref\|ZP_02306802.1\| 2-isopropylmalate synthase [Yersinia pestis biovar Antiqua str. UG05... gi\|166206878, gi... - gi\|166212132\|ref\|ZP_02238167.1\| 2-isopropylmalate synthase [Yersinia pestis biovar Antiqua str. B420... gi\|45443381, gi\|... - gi\|45443381\|ref\|NP_994920.1\| 2-isopropylmalate synthase [Yersinia pestis biovar Microtus str. 91001]... gi\|16120862, gi\|... - gi\|218927730\|ref\|YP_002345605.1\| 2-isopropylmalate synthase [Yersinia pestis CO92], gi\|16120862\|ref\|... LEU1_YERPS - 2-isopropylmalate synthase OS=Yersinia pseudotuberculosis serotype I (strain IP32953) GN=leuA PE=3 S... LEU1_YERPG - 2-isopropylmalate synthase OS=Yersinia pestis bv. Antiqua (strain Angola) GN=leuA PE=3 SV=1 LEU1_YERP3 - 2-isopropylmalate synthase OS=Yersinia pseudotuberculosis serotype O:1b (strain IP 31758) GN=leuA PE... LEU1_YERPN - 2-isopropylmalate synthase OS=Yersinia pestis bv. Antiqua (strain Nepal516) GN=leuA PE=3 SV=1 LEU1_YERPE - 2-isopropylmalate synthase OS=Yersinia pestis GN=leuA PE=3 SV=1 gi\|167469504 - gi\|167469504\|ref\|ZP_02334208.1\| 2-isopropylmalate synthase [Yersinia pestis FV-1] gi\|166960132, gi... - gi\|167421995\|ref\|ZP_02313748.1\| 2-isopropylmalate synthase [Yersinia pestis biovar Orientalis str. M... LEU1_YERPB - 2-isopropylmalate synthase OS=Yersinia pseudotuberculosis serotype IB (strain PB1/+) GN=leuA PE=3 SV... gi\|149289839, gi... - gi\|150260431\|ref\|ZP_01917159.1\| 2-isopropylmalate synthase [Yersinia pestis CA88-4125], gi\|149289839... LEU1_YERPY - 2-isopropylmalate synthase OS=Yersinia pseudotuberculosis serotype O:3 (strain YPIII) GN=leuA PE=3 S... gi\|229836878, gi... - gi\|229836878\|ref\|ZP_04457043.1\| 2-isopropylmalate synthase [Yersinia pestis Pestoides A], gi\|2297058... LEU1_YERPP - 2-isopropylmalate synthase OS=Yersinia pestis (strain Pestoides F) GN=leuA PE=3 SV=1 gi\|229840424, gi... - gi\|229840424\|ref\|ZP_04460583.1\| 2-isopropylmalate synthase [Yersinia pestis biovar Orientalis str. P... gi\|229843035, gi... - gi\|229843035\|ref\|ZP_04463185.1\| 2-isopropylmalate synthase [Yersinia pestis biovar Orientalis str. I...	0.0	[33..439]	[1..424]
gi\|3282740, gi\|1... - gi\|3282740\|gb\|AAD12600.1\| 2-isopropylmalate synthase [Buchnera aphidicola], gi\|10954458\|ref\|NP_04718... LEU1_BUCDN - 2-isopropylmalate synthase OS=Buchnera aphidicola subsp. Diuraphis noxia GN=leuA PE=3 SV=1	0.0	[33..439]	[1..424]
LEU1_BUCAP - 2-isopropylmalate synthase OS=Buchnera aphidicola subsp. Schizaphis graminum (strain Sg) GN=leuA PE=... gi\|219730356\|emb... - unnamed protein product [Buchnera aphidicola], unnamed protein product [Buchnera aphidicola], unname... LEU1_BUCAP - 2-isopropylmalate synthase OS=Buchnera aphidicola subsp. Schizaphis graminum GN=leuA PE=3 SV=1	0.0	[33..439]	[1..425]
LEU1_BUCAI - 2-isopropylmalate synthase OS=Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) GN=leuA PE... LEU1_BUCAI - 2-isopropylmalate synthase OS=Buchnera aphidicola subsp. Acyrthosiphon pisum GN=leuA PE=3 SV=3 gi\|219783132\|emb... - unnamed protein product [Buchnera aphidicola], unnamed protein product [Buchnera aphidicola], unname...	0.0	[33..439]	[1..425]
LEU1_BUCRP - 2-isopropylmalate synthase OS=Buchnera aphidicola subsp. Rhopalosiphum padi GN=leuA PE=3 SV=1 gi\|899388 - gi\|899388\|emb\|CAA50615.1\| 2-isopropylmalate synthase [Buchnera aphidicola]	0.0	[33..439]	[1..425]
LEU1_ECOLU - 2-isopropylmalate synthase OS=Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC) GN=leuA PE=3 SV=1 gi\|217321924, gi... - gi\|217325703\|ref\|ZP_03441787.1\| 2-isopropylmalate synthase [Escherichia coli O157:H7 str. TW14588], ... LEU1_ECO5E - 2-isopropylmalate synthase OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) GN=leuA PE=3 SV=1 gi\|208741018, gi... - gi\|208820895\|ref\|ZP_03261215.1\| 2-isopropylmalate synthase [Escherichia coli O157:H7 str. EC4042], g... gi\|254791212, gi... - gi\|254791212\|ref\|YP_003076049.1\| 2-isopropylmalate synthase [Escherichia coli O157:H7 str. TW14359],... LEU1_ECO57 - 2-isopropylmalate synthase OS=Escherichia coli O157:H7 GN=leuA PE=3 SV=3 gi\|189370825, gi... - gi\|189370825\|gb\|EDU89241.1\| 2-isopropylmalate synthase [Escherichia coli O157:H7 str. EC869], gi\|168... gi\|25311587, gi\|... - pir\|\|F85489 2-isopropylmalate synthase [imported] - Escherichia coli (strain O157:H7, substrain EDL... gi\|168781958, gi... - gi\|189000468\|gb\|EDU69454.1\| 2-isopropylmalate synthase [Escherichia coli O157:H7 str. EC4076], gi\|16... gi\|187767772, gi... - gi\|187767772\|gb\|EDU31616.1\| 2-isopropylmalate synthase [Escherichia coli O157:H7 str. EC4196], gi\|16... gi\|15799758, gi\|... - gi\|15799758\|ref\|NP_285770.1\| 2-isopropylmalate synthase [Escherichia coli O157:H7 EDL933], gi\|125127... gi\|189359889, gi... - gi\|189359889\|gb\|EDU78308.1\| 2-isopropylmalate synthase [Escherichia coli O157:H7 str. EC4486], gi\|16... gi\|208812302, gi... - gi\|208812302\|ref\|ZP_03253631.1\| 2-isopropylmalate synthase [Escherichia coli O157:H7 str. EC4045], g... gi\|208729331, gi... - gi\|208809530\|ref\|ZP_03251867.1\| 2-isopropylmalate synthase [Escherichia coli O157:H7 str. EC4206], g... gi\|195939291 - gi\|195939291\|ref\|ZP_03084673.1\| 2-isopropylmalate synthase [Escherichia coli O157:H7 str. EC4024] gi\|189376350, gi... - gi\|189376350\|gb\|EDU94766.1\| 2-isopropylmalate synthase [Escherichia coli O157:H7 str. EC508], gi\|168... gi\|168764048, gi... - gi\|189365887\|gb\|EDU84303.1\| 2-isopropylmalate synthase [Escherichia coli O157:H7 str. EC4501], gi\|16... gi\|189357002, gi... - gi\|189357002\|gb\|EDU75421.1\| 2-isopropylmalate synthase [Escherichia coli O157:H7 str. EC4401], gi\|16... gi\|15829332, gi\|... - gi\|15829332\|ref\|NP_308105.1\| 2-isopropylmalate synthase [Escherichia coli O157:H7 str. Sakai], gi\|13... gi\|188014548, gi... - gi\|188014548\|gb\|EDU52670.1\| 2-isopropylmalate synthase [Escherichia coli O157:H7 str. EC4113], gi\|16...	0.0	[33..437]	[1..422]

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Predicted Domain #1

Region A:
Residues: [1-328]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSENNEFQSV TESTTAPTTS NPYGPNPADY LSNVKNFQLI DSTLREGEQF ANAFFDTEKK  60
   61 IEIARALDDF GVDYIELTSP VASEQSRKDC EAICKLGLKA KILTHIRCHM DDARVAVETG 120
  121 VDGVDVVIGT SKFLRQYSHG KDMNYIAKSA VEVIEFVKSK GIEIRFSSED SFRSDLVDLL 180
  181 NIYKTVDKIG VNRVGIADTV GCANPRQVYE LIRTLKSVVS CDIECHFHND TGCAIANAYT 240
  241 ALEGGARLID VSVLGIGERN GITPLGGLMA RMIVAAPDYV RSKYKLHKIR DIENLVADAV 300
  301 EVNIPFNNPI TGFCAFTHKA GIHAKAIL

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	11.52
Match:	1euaA
Description:	KDPG aldolase
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [329-440]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ANPSTYEILD PHDFGMKRYI HFANRLTGWN AIKSRVDQLN LNLTDDQIKE VTAKIKKLGD  60
   61 VRPLNIDDVD SIIKDFHAEL STPLLKPVNK GTDDDNIDIS NGHVSKKAKV TK

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.694	0.837	nucleus	a.74.1	Cyclin-like
View	Download	0.457	0.837	nucleus	a.24.13	Domain of the SRP/SRP receptor G-proteins
View	Download	0.506	0.837	nucleus	a.69.1	C-terminal domain of alpha and beta subunits of F1 ATP synthase
View	Download	0.443	0.837	nucleus	a.24.13	Domain of the SRP/SRP receptor G-proteins
View	Download	0.417	0.837	nucleus	a.74.1	Cyclin-like
View	Download	0.405	0.837	nucleus	a.56.1	CO dehydrogenase ISP C-domain like
View	Download	0.403	0.837	nucleus	a.74.1	Cyclin-like
View	Download	0.396	0.837	nucleus	a.74.1	Cyclin-like
View	Download	0.378	0.837	nucleus	a.60.13	Putative methyltransferase TM0872, insert domain
View	Download	0.364	0.837	nucleus	a.177.1	Sigma2 domain of RNA polymerase sigma factors
View	Download	0.364	0.837	nucleus	d.65.1	Hedgehog/DD-pepidase
View	Download	0.364	0.837	nucleus	a.142.1	PTS-regulatory domain, PRD
View	Download	0.363	0.837	nucleus	d.203.1	DsrC, the gamma subunit of dissimilatory sulfite reductase
View	Download	0.352	0.837	nucleus	a.74.1	Cyclin-like
View	Download	0.309	0.837	nucleus	a.22.1	Histone-fold
View	Download	0.285	0.837	nucleus	a.39.1	EF-hand
View	Download	0.284	0.837	nucleus	a.74.1	Cyclin-like
View	Download	0.278	0.837	nucleus	a.74.1	Cyclin-like
View	Download	0.276	0.837	nucleus	a.165.1	Myosin phosphatase inhibitor 17kDa protein, CPI-17
View	Download	0.267	0.837	nucleus	a.5.6	Hypothetical protein MTH1615
View	Download	0.255	0.837	nucleus	a.5.3	N-terminal domain of phosphatidylinositol transfer protein sec14p
View	Download	0.255	0.837	nucleus	a.52.1	Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View	Download	0.254	0.837	nucleus	a.27.1	Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View	Download	0.249	0.837	nucleus	a.61.1	Retroviral matrix proteins
View	Download	0.238	0.837	nucleus	a.39.1	EF-hand
View	Download	0.228	0.837	nucleus	a.39.1	EF-hand
View	Download	0.214	0.837	nucleus	a.74.1	Cyclin-like
View	Download	0.201	0.837	nucleus	a.1.1	Globin-like

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits