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View Structure Prediction Details

Protein: NDE2
Organism: Saccharomyces cerevisiae
Length: 545 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NDE2.

Description E-value Query
Range
Subject
Range
gi|151941917 - gi|151941917|gb|EDN60273.1| type II NAD(P)H:quinone oxidoreductase [Saccharomyces cerevisiae YJM789]
gi|190405091 - gi|190405091|gb|EDV08358.1| type II NAD(P)H:quinone oxidoreductase [Saccharomyces cerevisiae RM11-1a...
NDH2_YEAST - External NADH-ubiquinone oxidoreductase 2, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 20...
NDE2 - Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2...
0.0 [1..545] [1..545]
NDH1_SCHPO - Probable NADH-ubiquinone oxidoreductase C3A11.07, mitochondrial OS=Schizosaccharomyces pombe (strain...
SPAC3A11.07 - NADH dehydrogenase
1.0E-98 [86..544] [80..549]
gi|3718005, gi|4... - gi|49651726|emb|CAG78667.1| YALI0F25135p [Yarrowia lipolytica], gi|3718005|emb|CAA07265.1| alternati...
NDH2_YARLI - External alternative NADH-ubiquinone oxidoreductase, mitochondrial OS=Yarrowia lipolytica (strain CL...
7.0E-92 [8..544] [36..580]
DLDH1_ARATH - Dihydrolipoyl dehydrogenase 1, mitochondrial OS=Arabidopsis thaliana GN=LPD1 PE=1 SV=2
3.0E-89 [50..524] [1..466]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
2.0E-87 [86..524] [26..460]
gi|4688668 - gi|4688668|emb|CAB41413.1| NADH dehydrogenase [Corynebacterium glutamicum]
gi|62390348, gi|... - gi|62390348|ref|YP_225750.1| NADH dehydrogenase [Corynebacterium glutamicum ATCC 13032], gi|41325685...
4.0E-87 [97..542] [12..424]

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Predicted Domain #1
Region A:
Residues: [1-87]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLPRLGFART ARSIHRFKMT QISKPFFHST EVGKPGPQQK LSKSYTAVFK KWFVRGLKLT  60
   61 FYTTLAGTLY VSYELYKESN PPKQVPQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.519 a.156.1 S13-like H2TH domain
View Download 0.472 a.2.3 Chaperone J-domain
View Download 0.519 a.156.1 S13-like H2TH domain
View Download 0.494 a.7.1 Spectrin repeat
View Download 0.472 a.2.3 Chaperone J-domain
View Download 0.494 a.7.1 Spectrin repeat
View Download 0.474 a.47.2 t-snare proteins
View Download 0.474 a.47.2 t-snare proteins
View Download 0.547 d.68.1 Translation initiation factor IF3, C-terminal domain
View Download 0.547 d.68.1 Translation initiation factor IF3, C-terminal domain
View Download 0.349 a.2.7 tRNA-binding arm
View Download 0.345 a.118.1 ARM repeat
View Download 0.332 d.95.2 Homing endonucleases
View Download 0.330 a.13.1 alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
View Download 0.314 a.12.1 Kix domain of CBP (creb binding protein)
View Download 0.302 a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain
View Download 0.298 a.47.2 t-snare proteins
View Download 0.296 d.52.5 Probable GTPase Der, C-terminal domain
View Download 0.295 d.68.1 Translation initiation factor IF3, C-terminal domain
View Download 0.287 a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.272 a.22.1 Histone-fold
View Download 0.263 d.74.3 RBP11-like subunits of RNA polymerase
View Download 0.259 a.39.1 EF-hand
View Download 0.255 a.24.7 FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
View Download 0.251 d.95.2 Homing endonucleases
View Download 0.245 a.1.1 Globin-like
View Download 0.243 a.64.1 Saposin
View Download 0.236 a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain
View Download 0.233 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.228 a.5.6 Hypothetical protein MTH1615
View Download 0.212 a.112.1 Description not found.
View Download 0.209 a.39.1 EF-hand
View Download 0.206 a.118.1 ARM repeat
View Download 0.204 d.39.1 Dynein light chain 8 (DLC8)
View Download 0.203 a.7.7 BAG domain
View Download 0.201 a.142.1 PTS-regulatory domain, PRD

Predicted Domain #2
Region A:
Residues: [88-210]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 STAFANGLKK KELVILGTGW GAISLLKKLD TSLYNVTVVS PRSFFLFTPL LPSTPVGTIE  60
   61 MKSIVEPVRS IARRTPGEVH YIEAEALDVD PKAKKVMVQS VSEDEYFVSS LSYDYLVVSV 120
  121 GAK

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [368-445]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NEPIDFSKTL MSRIPEQTNR RGLLINDKLE LLGSENSIYA IGDCTAHTGF FPTAQVAHQE  60
   61 GEYLAKILDK KLQIEQLE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 85.221849
Match: 1dxlA_
Description: Dihydrolipoamide dehydrogenase
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [211-367]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TTTFNIPGVY GNANFLKEIE DAQNIRMKLM KTIEQASSFP VNDPERKRLL TFVVVGGGPT  60
   61 GVEFAAELQD YINQDLRKWM PDLSKEMKVI LIEALPNILN MFDKTLIKYA EDLFARDEID 120
  121 LQVNTAVKVV EPTYIRTLQN GQTNTDIEYG MLVWATG

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [446-545]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WDMLNSTDET EVSRLQKEVN LRKSKLDKFN YKHMGALAYI GSETAIADLH MGDSSYQLKG  60
   61 MFAFLFWKSA YLAMCLSIRN RILIAMDWTK VYFLGRDSSV 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 85.221849
Match: 1dxlA_
Description: Dihydrolipoamide dehydrogenase
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle