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View Structure Prediction Details

Protein: BRE1
Organism: Saccharomyces cerevisiae
Length: 700 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for BRE1.

Description E-value Query
Range
Subject
Range
MYH4_PIG - Myosin-4 OS=Sus scrofa GN=MYH4 PE=2 SV=1
6.0E-78 [1..658] [1048..1690]
MYH4_RABIT - Myosin-4 OS=Oryctolagus cuniculus GN=MYH4 PE=1 SV=1
1.0E-76 [1..658] [1049..1691]
MYH1 - myosin, heavy chain 1, skeletal muscle, adult
2.0E-76 [1..658] [1050..1692]
MYH2_BOVIN - Myosin-2 OS=Bos taurus GN=MYH2 PE=2 SV=1
2.0E-76 [1..658] [1051..1693]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
2.0E-76 [1..658] [47..689]
gi|6683485 - gi|6683485|dbj|BAA89233.1| skeletal myosin heavy chain [Gallus gallus]
2.0E-76 [1..658] [1050..1692]

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Predicted Domain #1
Region A:
Residues: [1-342]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTAEPATKKI KLELSDPSEP LTQSDVIAFQ KEALFRCINR RRVDFEALRK QYELSRRECI  60
   61 DVSRKLANIM ALIVTLARFI ETFCTDANEK QLCREIAQGD ETLIVQRSDS FMKLLTKYGK 120
  121 PNTTDSNTNS NASDHIQELT TELKNLRKSK EELFYENSQL TEEISALKEY YTNIIRKYDR 180
  181 DESFTIKRVF KEDKTDAVKE LREDEKESNE NNIKSGNKDS SAINGDNTSK KSEKGDELVQ 240
  241 AEDERKEDAE NEKLELDLKF SDLRAEINSL SSTIKDLENI RRENEEELIK TRSEVSNLKK 300
  301 QQIAAADQDP DFKSYDHESL LAKIQHLTEQ NAELSEINSS FL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 21.522879
Match: 1i84S_
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [343-400]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKFQVLAKEK EIYTKKVREE FQKSLDSLVE MNSSLEKDVV RIRTARDDLL SKIAILEA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.545 a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.607 a.30.1 ROP protein
View Download 0.536 d.43.1 Elongation factor Ts (EF-Ts), dimerisation domain
View Download 0.535 a.126.1 Serum albumin-like
View Download 0.641 a.2.2 Ribosomal protein L29 (L29p)
View Download 0.520 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.481 a.2.9 C-terminal UvrC-binding domain of UvrB
View Download 0.388 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.386 g.2.2 Neurotoxin B-IV
View Download 0.384 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.376 f.13.1 Family A G protein-coupled receptor-like
View Download 0.355 a.4.1 Homeodomain-like
View Download 0.354 a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.341 a.2.8 Eukaryotic DNA topoisomerase I, dispensable insert domain
View Download 0.297 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.293 a.2.10 Epsilon subunit of F1F0-ATP synthase C-terminal domain
View Download 0.291 a.64.1 Saposin
View Download 0.289 a.30.2 Homodimeric domain of signal transducing histidine kinase
View Download 0.285 a.2.7 tRNA-binding arm
View Download 0.283 a.48.3 Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
View Download 0.278 a.5.1 DNA helicase RuvA subunit, C-terminal domain
View Download 0.263 a.2.7 tRNA-binding arm
View Download 0.263 a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.244 d.120.1 Cytochrome b5
View Download 0.243 a.108.1 Ribosomal protein L7/12, oligomerisation (N-terminal) domain
View Download 0.240 c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.230 a.157.1 Skp1 dimerisation domain-like
View Download 0.230 a.46.1 Methionine synthase domain
View Download 0.222 a.4.5 "Winged helix" DNA-binding domain
View Download 0.221 a.90.1 Transcription factor STAT-4 N-domain
View Download 0.220 d.58.17 Metal-binding domain
View Download 0.213 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.212 a.24.4 Hemerythrin
View Download 0.208 a.66.1 Transducin (alpha subunit), insertion domain

Predicted Domain #3
Region A:
Residues: [401-470]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EKSKTEVLSD LQHAIDILKE QWTKIDQRSN DTKSSSTQDA LIKEIQDLEK GFRELSDLTH  60
   61 KKYSEIINHE 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 9.522879
Match: 1c1gA_
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [471-700]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SVISKLTVEK TKADQKYFAA MRSKDSILIE IKTLSKSLSK SNELILQLKD SDRLLQQKIG  60
   61 NLHKQLDLSQ NNERRLIDSS KTETLKIIDL NNTSTKLKRS LEKLQEESNK SIADMTHLET 120
  121 KLNDTEIELK HFKQKASHLE SKCEKLHDTL FRGNNKNKGS SDEALVEELA NFRTLVYCSL 180
  181 CSKNWKNMAI KTCGHVFCEN CCKERLAARM RKCPTCNKAF SSNDLLTVHL 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 9.522879
Match: 1c1gA_
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle