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View Structure Prediction Details

Protein: PDI1
Organism: Saccharomyces cerevisiae
Length: 522 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PDI1.

Description E-value Query
Range
Subject
Range
PDI_YEAST - Protein disulfide-isomerase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PDI1 PE=1 SV...
PDI1 - Protein disulfide isomerase, multifunctional protein resident in the endoplasmic reticulum lumen, es...
0.0 [1..522] [1..522]
PDIA1_RABIT - Protein disulfide-isomerase OS=Oryctolagus cuniculus GN=P4HB PE=2 SV=1
0.0 [8..497] [1..488]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [1..493] [1..493]
PDI_ASPNG - Protein disulfide-isomerase OS=Aspergillus niger GN=pdiA PE=2 SV=1
0.0 [8..522] [1..515]
gi|5326749 - gi|5326749|gb|AAD42032.1|AF075246_1 protein disulfide isomerase precursor [Kluyveromyces marxianus]
0.0 [15..496] [14..491]
gi|5650705, gi|4... - gi|5650705|emb|CAB51612.1| protein disulfide isomerase [Kluyveromyces lactis], gi|49641377|emb|CAH01...
gi|50304577, gi|... - gi|50304577|ref|XP_452244.1| unnamed protein product [Kluyveromyces lactis], gi|49641377|emb|CAH0109...
0.0 [12..496] [11..491]

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Predicted Domain #1
Region A:
Residues: [1-142]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKFSAGAVLS WSSLLLASSV FAQQEAVAPE DSAVVKLATD SFNEYIQSHD LVLAEFFAPW  60
   61 CGHCKNMAPE YVKAAETLVE KNITLAQIDC TENQDLCMEH NIPGFPSLKI FKNSDVNNSI 120
  121 DYEGPRTAEA IVQFMIKQSQ PA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 239.67837
Match: 1mek__
Description: Protein disulfide isomerase, PDI
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [143-309]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VAVVADLPAY LANETFVTPV IVQSGKIDAD FNATFYSMAN KHFNDYDFVS AENADDDFKL  60
   61 SIYLPSAMDE PVVYNGKKAD IADADVFEKW LQVEALPYFG EIDGSVFAQY VESGLPLGYL 120
  121 FYNDEEELEE YKPLFTELAK KNRGLMNFVS IDARKFGRHA GNLNMKE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 9.0
Match: 1bjx__
Description: Protein disulfide isomerase, PDI
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [310-370]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QFPLFAIHDM TEDLKYGLPQ LSEEAFDELS DKIVLESKAI ESLVKDFLKG DASPIVKSQE  60
   61 I

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.681 a.4.5 "Winged helix" DNA-binding domain
View Download 0.680 a.4.1 Homeodomain-like
View Download 0.729 a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.649 a.4.1 Homeodomain-like
View Download 0.608 a.5.2 UBA-like
View Download 0.592 a.4.1 Homeodomain-like
View Download 0.531 a.5.7 4-hydroxy-2-oxovalerate aldolase DmpG, communication domain
View Download 0.507 a.144.1 PABC (PABP) domain
View Download 0.457 a.4.5 "Winged helix" DNA-binding domain
View Download 0.434 a.48.3 Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
View Download 0.431 a.4.10 N-terminal Zn binding domain of HIV integrase
View Download 0.429 a.60.12 DNA polymerase beta-like, second domain
View Download 0.421 a.5.1 DNA helicase RuvA subunit, C-terminal domain
View Download 0.407 d.68.7 R3H domain
View Download 0.402 a.4.5 "Winged helix" DNA-binding domain
View Download 0.361 a.60.9 lambda integrase-like, N-terminal domain
View Download 0.322 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.308 a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.304 a.4.1 Homeodomain-like
View Download 0.295 a.64.2 Bacteriocin AS-48
View Download 0.291 d.58.17 Metal-binding domain
View Download 0.280 a.159.1 Protein serine/threonine phosphatase 2C, C-terminal domain
View Download 0.272 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.260 a.5.1 DNA helicase RuvA subunit, C-terminal domain
View Download 0.259 a.5.1 DNA helicase RuvA subunit, C-terminal domain
View Download 0.253 a.60.1 SAM/Pointed domain
View Download 0.252 a.108.1 Ribosomal protein L7/12, oligomerisation (N-terminal) domain
View Download 0.249 a.60.2 RuvA domain 2-like
View Download 0.249 a.65.1 Annexin
View Download 0.245 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.242 a.179.1 Replisome organizer (g39p helicase loader/inhibitor protein)
View Download 0.241 a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.236 c.3.1 FAD/NAD(P)-binding domain
View Download 0.234 a.118.11 Cytochrome c oxidase subunit E
View Download 0.231 a.39.1 EF-hand
View Download 0.218 a.153.1 Nuclear receptor coactivator interlocking domain
View Download 0.210 a.101.1 Uteroglobin-like
View Download 0.209 a.60.11 Hypothetical protein YjbJ
View Download 0.206 d.50.3 PI-Pfui intein middle domain
View Download 0.205 a.60.3 C-terminal domain of RNA polymerase alpha subunit

Predicted Domain #4
Region A:
Residues: [371-522]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FENQDSSVFQ LVGKNHDEIV NDPKKDVLVL YYAPWCGHCK RLAPTYQELA DTYANATSDV  60
   61 LIAKLDHTEN DVRGVVIEGY PTIVLYPGGK KSESVVYQGS RSLDSLFDFI KENGHFDVDG 120
  121 KALYEEAQEK AAEEADADAE LADEEDAIHD EL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 94.67837
Match: 1t7pB_
Description: Thioredoxin
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle