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View Structure Prediction Details

Protein: CHK1
Organism: Saccharomyces cerevisiae
Length: 527 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CHK1.

Description E-value Query
Range
Subject
Range
CDPKH_ARATH - Calcium-dependent protein kinase 17 OS=Arabidopsis thaliana GN=CPK17 PE=2 SV=1
0.0 [15..471] [73..523]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [9..463] [87..534]
gi|5162882, gi|5... - gi|5162882|dbj|BAA81751.1| calcium-dependent protein kinase [Marchantia polymorpha], gi|5162878|dbj|...
0.0 [15..479] [81..539]
gi|19171502 - gi|19171502|emb|CAC87494.1| calcium-dependent protein kinase [Solanum lycopersicum]
0.0 [9..465] [99..548]

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Predicted Domain #1
Region A:
Residues: [1-64]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLSQVSPLP HIKDVVLGDT VGQGAFACVK NAHLQMDPSI ILAVKFIHVP TCKKMGLSDK  60
   61 DITK

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [82-96]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IDCNVSKEYM WIILE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 500.616428
Match: 1ia8A_
Description: Cell cycle checkpoint kinase chk1
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [65-81]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EVVLQSKCSK HPNVLRL

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [97-106]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADGGDLFDK 

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [122-175]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FQQLVSAINY LHVECGVAHR DIKPENILLD KNGNLKLADF GLASQFRRKD GTLR

[Run NCBI BLAST on this sequence.]

Region D:
Residues: [287-307]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FSGDDGLCND PELLAKKLFS H

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 500.616428
Match: 1ia8A_
Description: Cell cycle checkpoint kinase chk1
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [107-121]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IEPDVGVDSD VAQFY

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [176-286]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VSMDQRGSPP YMAPEVLYSE EGYYADRTDI WSIGILLFVL LTGQTPWELP SLENEDFVFF  60
   61 IENDGNLNWG PWSKIEFTHL NLLRKILQPD PNKRVTLKAL KLHPWVLRRA S

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 500.616428
Match: 1ia8A_
Description: Cell cycle checkpoint kinase chk1
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [308-395]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LKVSLSNENY LKFTQDTNSN NRYISTQPIG NELAELEHDS MHFQTVSNTQ RAFTSYDSNT  60
   61 NYNSGTGMTQ EAKWTQFISY DIAALQFH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.045757
Match: 1iq5A_
Description: Calmodulin
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [396-527]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SDENDCNELV KRHLQFNPNK LTKFYTLQPM DVLLPILEKA LNLSQIRVKP DLFANFERLC  60
   61 ELLGYDNVFP LIINIKTKSN GGYQLCGSIS IIKIEEELKS VGFERKTGDP LEWRRLFKKI 120
  121 STICRDIILI PN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.045757
Match: 1iq5A_
Description: Calmodulin
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle