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View Structure Prediction Details

Protein: AME1
Organism: Saccharomyces cerevisiae
Length: 324 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for AME1.

Description E-value Query
Range
Subject
Range
AME1_YEAST - Central kinetochore subunit AME1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=AME1 PE...
AME1 - Essential kinetochore protein associated with microtubules and spindle pole bodies; component of the...
0.0 [1..324] [1..324]

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Predicted Domain #1
Region A:
Residues: [1-92]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDRDTKLAFR LRGSHSRRTD DIDDDVIVFK TPNAVYREEN SPIQSPVQPI LSSPKLANSF  60
   61 EFPITTNNVN AQDRHEHGYQ PLDAEDYPMI DS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.428 a.6.1 Putative DNA-binding domain
View Download 0.349 d.120.1 Cytochrome b5
View Download 0.227 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.364 a.21.1 HMG-box
View Download 0.227 a.64.1 Saposin
View Download 0.209 a.64.2 Bacteriocin AS-48

Predicted Domain #2
Region A:
Residues: [93-324]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ENKSLISESP QNVRNDEDLT TRYNFDDIPI RQLSSSITSV TTIDVLSSLF INLFENDLIP  60
   61 QALKDFNKSD DDQFRKLLYK LDLRLFQTIS DQMTRDLKDI LDINVSNNEL CYQLKQVLAR 120
  121 KEDLNQQIIS VRNEIQELKA GKDWHDLQNE QAKLNDKVKL NKRLNDLTST LLGKYEGDRK 180
  181 IMSQDSEDDS IRDDSNILDI AHFVDLMDPY NGLLKKINKI NENLSNELQP SL

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.48
Match: 1qoyA
Description: Hemolysin E (HlyE, ClyA, SheA)
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle