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View Structure Prediction Details

Protein: CKS1
Organism: Saccharomyces cerevisiae
Length: 150 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CKS1.

Description E-value Query
Range
Subject
Range
CKS1_YEAST - Cyclin-dependent kinases regulatory subunit OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c)...
CKS1 - Cyclin-dependent protein kinase regulatory subunit and adaptor; modulates proteolysis of M-phase tar...
gi|151946525 - gi|151946525|gb|EDN64747.1| cyclin-dependent protein kinase subunit [Saccharomyces cerevisiae YJM789...
2.0E-49 [1..150] [1..150]
gi|157833583, gi... - gi|157833583|pdb|1PUC|A Chain A, P13suc1 In A Strand-Exchanged Dimer, gi|1421400|pdb|1PUC| Chain ,...
1.0E-35 [11..107] [7..103]
suc1 - cyclin-dependent protein kinase regulatory subunit Suc1
CKS1_SCHPO - Cyclin-dependent kinases regulatory subunit OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) G...
2.0E-35 [11..107] [8..104]
gi|3108171, gi|3... - gi|3108171|gb|AAC15772.1| Cdc2 binding protein Suc1 [Pneumocystis carinii f. sp. carinii], gi|310816...
1.0E-32 [11..111] [11..111]
CE22913 - status:Partially_confirmed UniProt:Q95XM4 protein_id:AAK73928.1
2.0E-30 [26..129] [2..98]
CKS1_LEIME - Cyclin-dependent kinases regulatory subunit OS=Leishmania mexicana PE=3 SV=1
1.0E-27 [21..104] [24..98]
CKS2_ARATH - Cyclin-dependent kinases regulatory subunit 2 OS=Arabidopsis thaliana GN=CKS2 PE=3 SV=1
2.0E-27 [27..115] [3..82]

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Predicted Domain #1
Region A:
Residues: [1-150]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYHHYHAFQG RKLTDQERAR VLEFQDSIHY SPRYSDDNYE YRHVMLPKAM LKVIPSDYFN  60
   61 SEVGTLRILT EDEWRGLGIT QSLGWEHYEC HAPEPHILLF KRPLNYEAEL RAATAAAQQQ 120
  121 QQQQQQQQQQ QQQHQTQSIS NDMQVPPQIS 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.313 0.721 protein kinase activator activity c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.325 0.018 protein kinase activator activity d.110.4 SNARE-like
View Download 0.233 0.010 protein kinase activator activity d.110.2 GAF domain-like
View Download 0.292 N/A N/A c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.243 N/A N/A d.87.1 FAD/NAD-linked reductases, dimerisation (C-terminal) domain
View Download 0.207 N/A N/A d.109.1 Actin depolymerizing proteins
View Download 0.203 N/A N/A d.110.2 GAF domain-like

Predicted functions:

Term Confidence Notes
cyclin-dependent protein kinase regulator activity 3.97841828100668 bayes_pls_golite062009
binding 2.18113207610794 bayes_pls_golite062009
protein binding 1.97943309243131 bayes_pls_golite062009
protein kinase regulator activity 1.37860707665544 bayes_pls_golite062009
kinase regulator activity 1.32978090173102 bayes_pls_golite062009
protein kinase binding 0.944579171364175 bayes_pls_golite062009
kinase binding 0.867010292327918 bayes_pls_golite062009
enzyme binding 0.54410658997703 bayes_pls_golite062009
enzyme regulator activity 0.334428481657021 bayes_pls_golite062009
small conjugating protein binding 0.32298430897304 bayes_pls_golite062009
ubiquitin binding 0.2354005843111 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle