YRC Public Data Repository - Protein Structure Prediction

Protein:	ORC2
Organism:	Saccharomyces cerevisiae
Length:	620 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ORC2.

Description	E-value	Query Range	Subject Range
ORC2_YEAST - Origin recognition complex subunit 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ORC... ORC2 - Subunit of the origin recognition complex, which directs DNA replication by binding to replication o...	0.0	[1..620]	[1..620]
gi\|7650495 - gi\|7650495\|gb\|AAF66068.1\|AF254573_1 origin recognition complex subunit 2 [Cricetulus griseus]	0.0	[40..614]	[30..570]
ORC2_MOUSE - Origin recognition complex subunit 2 OS=Mus musculus GN=Orc2 PE=1 SV=1	0.0	[16..614]	[7..570]
gi\|1142706, gi\|1... - gi\|1587281\|prf\|\|2206380B origin recognition complex subunit, gi\|1142706\|gb\|AAB33970.1\| hORC2L [Homo ...	0.0	[40..614]	[30..571]
gi\|1136134 - gi\|1136134\|gb\|AAC46955.1\| DmORC2	0.0	[3..615]	[25..614]
ORC2_XENLA - Origin recognition complex subunit 2 OS=Xenopus laevis GN=orc2 PE=2 SV=1	0.0	[85..614]	[79..552]
ORC2_SCHPO - Origin recognition complex subunit 2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=orc2 ... orc2 - origin recognition complex subunit Orc2	0.0	[83..617]	[36..532]
gi\|15866776, gi\|... - gi\|195645744\|gb\|ACG42340.1\| origin recognition complex subunit 2 [Zea mays], gi\|162460144\|ref\|NP_001...	0.0	[222..616]	[3..376]
ORC2_ARATH - Origin of replication complex subunit 2 OS=Arabidopsis thaliana GN=ORC2 PE=1 SV=1	0.0	[232..616]	[2..361]

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Predicted Domain #1

Region A:
Residues: [1-260]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLNGEDFVEH NDILSSPAKS RNVTPKRVDP HGERQLRRIH SSKKNLLERI SLVGNERKNT  60
   61 SPDPALKPKT PSKAPRKRGR PRKIQEELTD RIKKDEKDTI SSKKKRKLDK DTSGNVNEES 120
  121 KTSNNKQVME KTGIKEKRER EKIQVATTTY EDNVTPQTDD NFVSNSPEPP EPATPSKKSL 180
  181 TTNHDFTSPL KQIIMNNLKE YKDSTSPGKL TLSRNFTPTP VPKNKKLYQT SETKSASSFL 240
  241 DTFEGYFDQR KIVRTNAKSR

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	12.87
Match:	1m2vB
Description:	Sec24
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [261-620]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HTMSMAPDVT REEFSLVSNF FNENFQKRPR QKLFEIQKKM FPQYWFELTQ GFSLLFYGVG  60
   61 SKRNFLEEFA IDYLSPKIAY SQLAYENELQ QNKPVNSIPC LILNGYNPSC NYRDVFKEIT 120
  121 DLLVPAELTR SETKYWGNHV ILQIQKMIDF YKNQPLDIKL ILVVHNLDGP SIRKNTFQTM 180
  181 LSFLSVIRQI AIVASTDHIY APLLWDNMKA QNYNFVFHDI SNFEPSTVES TFQDVMKMGK 240
  241 SDTSSGAEGA KYVLQSLTVN SKKMYKLLIE TQMQNMGNLS ANTGPKRGTQ RTGVELKLFN 300
  301 HLCAADFIAS NEIALRSMLR EFIEHKMANI TKNNSGMEII WVPYTYAELE KLLKTVLNTL 360
  361

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits