YRC Public Data Repository - Protein Structure Prediction

Protein:	GAL1
Organism:	Saccharomyces cerevisiae
Length:	528 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GAL1.

Description	E-value	Query Range	Subject Range
GAL1_YEAST - Galactokinase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GAL1 PE=1 SV=4 GAL1 - Galactokinase, phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step o... gi\|151946413 - gi\|151946413\|gb\|EDN64635.1\| galactokinase [Saccharomyces cerevisiae YJM789]	0.0	[1..528]	[1..528]
gi\|171567\|gb\|AAA... - gal1 gi\|171567 - gi\|171567\|gb\|AAA34631.1\| gal1	0.0	[1..528]	[1..528]
GAL1_KLULA - Galactokinase OS=Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-... GAL1_KLULA - Galactokinase OS=Kluyveromyces lactis GN=GAL1 PE=2 SV=2	0.0	[10..527]	[2..503]
SPBPB2B2.13 - galactokinase Gal1 GAL1_SCHPO - Galactokinase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=gal1 PE=3 SV=1	0.0	[10..528]	[3..516]
GAL1_CANAX - Galactokinase OS=Candida albicans GN=GAL1 PE=3 SV=1	0.0	[10..526]	[2..509]
GAL1_CANPA - Galactokinase OS=Candida parapsilosis GN=GAL1 PE=3 SV=1	0.0	[10..528]	[2..496]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[7..528]	[5..496]
GALK1_ARATH - Galactokinase OS=Arabidopsis thaliana GN=GAL1 PE=1 SV=2	0.0	[7..528]	[5..496]

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Predicted Domain #1

Region A:
Residues: [1-50]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTKSHSEEVI VPEFNSSAKE LPRPLAEKCP SIIKKFISAY DAKPDFVARS

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [77-213]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLCAVKVLNE KNPSITLINA DPKFAQRKFD LPLDGSYVTI DPSVSDWSNY FKCGLHVAHS  60
   61 FLKKLAPERF ASAPLAGLQV FCEGDVPTGS GLSSSAAFIC AVALAVVKAN MGPGYHMSKQ 120
  121 NLMRITVVAE HYVGVNN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	70.0
Match:	1kkhA_
Description:	Mevalonate kinase
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [51-76]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PGRVNLIGEH IDYCDFSVLP LAIDFD

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [214-372]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGMDQAASVC GEEDHALYVE FKPQLKATPF KFPQLKNHEI SFVIANTLVV SNKFETAPTN  60
   61 YNLRVVEVTT AANVLAATYG VVLLSGKEGS STNKGNLRDF MNVYYARYHN ISTPWNGDIE 120
  121 SGIERLTKML VLVEESLANK KQGFSVDDVA QSLNCSREE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	70.0
Match:	1kkhA_
Description:	Mevalonate kinase
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [373-528]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FTRDYLTTSP VRFQVLKLYQ RAKHVYSESL RVLKAVKLMT TASFTADEDF FKQFGALMNE  60
   61 SQASCDKLYE CSCPEIDKIC SIALSNGSYG SRLTGAGWGG CTVHLVPGGP NGNIEKVKEA 120
  121 LANEFYKVKY PKITDAELEN AIIVSKPALG SCLYEL

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	13.73
Match:	1kvkA
Description:	Mevalonate kinase
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits