YRC Public Data Repository - Protein Structure Prediction

Protein:	RPF2_SCHPO
Organism:	Schizosaccharomyces pombe 972h-
Length:	317 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RPF2_SCHPO.

Description	E-value	Query Range	Subject Range
gi\|31982662, gi\|... - gi\|31982662\|ref\|NP_075812.2\| brix domain containing 1 [Mus musculus], gi\|19263817\|gb\|AAH25093.1\| Bri...	397.0	[0..3]	[307..6]
gi\|165970868, gi... - gi\|27705690\|ref\|XP_215404.1\| PREDICTED: similar to brix domain containing 1 [Rattus norvegicus], gi\|...	397.0	[0..3]	[307..6]
gi\|148223607, gi... - gi\|28461332\|gb\|AAH46945.1\| Bxdc1-prov protein [Xenopus laevis], gi\|148223607\|ref\|NP_001080306.1\| bri...	387.0	[0..3]	[303..6]
gi\|46108586, gi\|... - gi\|46108586\|ref\|XP_381351.1\| hypothetical protein FG01175.1 [Gibberella zeae PH-1], gi\|42545798\|gb\|E...	386.0	[0..1]	[310..1]
gi\|109073017 - gi\|109073017\|ref\|XP_001087115.1\| PREDICTED: brix domain containing 1 [Macaca mulatta]	386.0	[0..3]	[311..6]
gi\|114608888 - gi\|114608888\|ref\|XP_001156493.1\| PREDICTED: brix domain containing 1 isoform 2 [Pan troglodytes] RPF2 - ribosome production factor 2 homolog (S. cerevisiae)	383.0	[0..3]	[307..6]
RPF2_YEAST - Ribosome biogenesis protein RPF2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RPF2 PE... RPF2 - Essential protein involved in the processing of pre-rRNA and the assembly of the 60S ribosomal subun...	382.0	[0..1]	[316..1]

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Predicted Domain #1

Region A:
Residues: [1-248]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRQVKPKNA RTKRALEKRE PKLVEGAKTA IFLRGNATSQ ISLDVLGDIH ALKKPFSVNF  60
   61 QKKNNILPFE DASSLEFFSE KNDAALAVMA THNKKRPHNL TWVRFFNYRV LDMIELGIVN 120
  121 YKSIQSFSAT PIVPGTKPMI LFQGPVFDAH PTYRHIKSLF LDFFRGEPIQ KLDSAGLSYV 180
  181 IVVSAAEAQE DETKPLPLVH FRVYGTKLLK TKTNLPRVEL EEMGPRIDFN IRRVQPAESD 240
  241 VLEEALKK

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	3.86
Match:	2cxhA
Description:	Crystal structure of probable ribosomal biogenesis protein from Aeropyrum pernix K1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
aminoacyl-tRNA ligase activity	3.51611427841435	bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds	3.51602790171379	bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds	3.51602790171379	bayes_pls_golite062009
ligase activity	2.39787140469438	bayes_pls_golite062009
binding	1.79619860046184	bayes_pls_golite062009
proline-tRNA ligase activity	1.61792117479721	bayes_pls_golite062009
catalytic activity	0.853948963582441	bayes_pls_golite062009
protein binding	0.668055564043996	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [249-317]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PKTQEPKPKK NVDVDIIGNK VGRIHVDQQD LGNLQTRKMK GLKRSVEERE DSENEEVEIE  60
   61 EDVISDASE

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: