YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|60816049, gi\|...
Organism:	synthetic construct
Length:	378 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|60816049, gi|....

Description	E-value	Query Range	Subject Range
gi\|60653087, gi\|... - gi\|60653087\|gb\|AAX29238.1\| CDC37 cell division cycle 37-like [synthetic construct], gi\|30585211\|gb\|A...	0.0	[1..378]	[1..378]
gi\|60820842 - gi\|60820842\|gb\|AAX36551.1\| CDC37 cell division cycle 37-like [synthetic construct] gi\|49457492 - gi\|49457492\|emb\|CAG47045.1\| CDC37 [Homo sapiens]	0.0	[1..378]	[1..378]
gi\|109123422 - gi\|109123422\|ref\|XP_001105596.1\| PREDICTED: CDC37 homolog [Macaca mulatta]	0.0	[1..378]	[1..429]
CDC37_RAT - Hsp90 co-chaperone Cdc37 OS=Rattus norvegicus GN=Cdc37 PE=1 SV=2	0.0	[1..377]	[1..378]
CDC37_MOUSE - Hsp90 co-chaperone Cdc37 OS=Mus musculus GN=Cdc37 PE=1 SV=1	0.0	[1..377]	[1..378]
gi\|73986801 - gi\|73986801\|ref\|XP_854103.1\| PREDICTED: similar to Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein...	0.0	[1..377]	[1..379]
CDC37_BOVIN - Hsp90 co-chaperone Cdc37 OS=Bos taurus GN=CDC37 PE=2 SV=1	0.0	[1..378]	[1..380]
gi\|51870491, gi\|... - gi\|51870491\|emb\|CAG15149.1\| CDC37 cell division cycle 37 protein [Sus scrofa], gi\|178057067\|ref\|NP_0... gi\|61553449 - gi\|61553449\|gb\|AAX46408.1\| CDC37 homolog [Bos taurus]	0.0	[1..377]	[1..379]

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Predicted Domain #1

Region A:
Residues: [1-131]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVDYSVWDHI EVSDDEDETH PNIDTASLFR WRHQARVERM EQFQKEKEEL DRGCRECKRK  60
   61 VAECQRKLKE LEVAEGGKAE LERLQAEAQQ LRKEERSWEQ KLEEMRKKEK SMPWNVDTLS 120
  121 KDGFSKSMVN T

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	60.251812
Match:	PF03234.5
Description:	No description for PF03234.5 was found.

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.589	N/A	N/A	a.24.9	alpha-catenin/vinculin
View	Download	0.512	N/A	N/A	f.14.1	Voltage-gated potassium channels
View	Download	0.501	N/A	N/A	a.24.9	alpha-catenin/vinculin
View	Download	0.454	N/A	N/A	a.24.14	FAT domain of focal adhesion kinase
View	Download	0.312	N/A	N/A	f.32.1	a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)

Predicted Domain #2

Region A:
Residues: [132-378]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KPEKTEEDSE EVREQKHKTF VEKYEKQIKH FGMLRRWDDS QKYLSDNVHL VCEETANYLV  60
   61 IWCIDLEVEE KCALMEQVAH QTIVMQFILE LAKSLKVDPR ACFRQFFTKI KTADRQYMEG 120
  121 FNDELEAFKE RVRGRAKLRI EKAMKEYEEE ERKKRLGPGG LDPVEVYESL PEELQKCFDV 180
  181 KDVQMLQDAI SKMDPTDAKY HMQRCIDSGL WVPNSKASEA KEGEEAGPGD PLLEAVPKTG 240
  241 DEKDVSV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	97.522879
Match:	1us7B
Description:	Complex of Hsp90 and P50
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	1.63059449218992	bayes_pls_golite062009
protein binding	0.967371813449539	bayes_pls_golite062009
unfolded protein binding	0.68193901105298	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: