YRC Public Data Repository - Protein Structure Prediction

Protein:	METK_SALPA
Organism:	Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150
Length:	384 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for METK_SALPA.

Description	E-value	Query Range	Subject Range
gi\|254037990, gi... - gi\|254037990\|ref\|ZP_04872048.1\| S-adenosylmethionine synthetase [Escherichia sp. 1_1_43], gi\|2268396... gi\|91073898, gi\|... - gi\|91212324\|ref\|YP_542310.1\| S-adenosylmethionine synthetase [Escherichia coli UTI89], gi\|91073898\|g... gi\|226899446, gi... - gi\|237706406\|ref\|ZP_04536887.1\| S-adenosylmethionine synthetase [Escherichia sp. 3_2_53FAA], gi\|2268... gi\|24114197, gi\|... - ref\|NP_708707.1\| methionine adenosyltransferase 1 (AdoMet synthetase); methyl and propylamine donor,... gi\|26109771, gi\|... - gi\|26249363\|ref\|NP_755403.1\| S-adenosylmethionine synthetase [Escherichia coli CFT073], gi\|26109771\|...	0.0	[1..384]	[5..388]
gi\|254289612, gi... - gi\|254289612\|ref\|YP_003055360.1\| S-adenosylmethionine synthetase [Escherichia coli BL21(DE3)], gi\|25... gi\|251786195, gi... - gi\|251786195\|ref\|YP_003000499.1\| hypothetical protein B21_02735 [Escherichia coli BL21], gi\|24237846... METK_ECOBW - S-adenosylmethionine synthase OS=Escherichia coli (strain K12 / MC4100 / BW2952) GN=metK PE=3 SV=1 gi\|227888496, gi... - gi\|227888496\|ref\|ZP_04006301.1\| S-adenosylmethionine synthetase [Escherichia coli 83972], gi\|2278347... METK_SHISS - S-adenosylmethionine synthase OS=Shigella sonnei (strain Ss046) GN=metK PE=3 SV=1 gi\|168773420, gi... - gi\|187770947\|gb\|EDU34791.1\| S-adenosylmethionine synthetase [Escherichia coli O157:H7 str. EC4196], ... METK_ECOL6 - S-adenosylmethionine synthase OS=Escherichia coli O6 GN=metK PE=3 SV=2 gi\|189000642, gi... - gi\|189000642\|gb\|EDU69628.1\| S-adenosylmethionine synthetase [Escherichia coli O157:H7 str. EC4076], ... gi\|192930746, gi... - gi\|75258550\|ref\|ZP_00729972.1\| COG0192: S-adenosylmethionine synthetase [Escherichia coli E22], gi\|1... gi\|189373892, gi... - gi\|189373892\|gb\|EDU92308.1\| S-adenosylmethionine synthetase [Escherichia coli O157:H7 str. EC869], g... gi\|75515278, gi\|... - gi\|75515278\|ref\|ZP_00737462.1\| COG0192: S-adenosylmethionine synthetase [Escherichia coli 53638], gi... METK_ECOLC - S-adenosylmethionine synthase OS=Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks) GN=metK PE=... gi\|168797516, gi... - gi\|189379804\|gb\|EDU98220.1\| S-adenosylmethionine synthetase [Escherichia coli O157:H7 str. EC508], g... gi\|56383766, gi\|... - gi\|56480215\|ref\|NP_708707.2\| S-adenosylmethionine synthetase [Shigella flexneri 2a str. 301], gi\|563... METK_ECODH - S-adenosylmethionine synthase OS=Escherichia coli (strain K12 / DH10B) GN=metK PE=3 SV=1 METK_ECOSM - S-adenosylmethionine synthase OS=Escherichia coli (strain SMS-3-5 / SECEC) GN=metK PE=3 SV=1 METK_SHIDS - S-adenosylmethionine synthase OS=Shigella dysenteriae serotype 1 (strain Sd197) GN=metK PE=3 SV=1 gi\|195936564 - gi\|195936564\|ref\|ZP_03081946.1\| S-adenosylmethionine synthetase [Escherichia coli O157:H7 str. EC402... gi\|89109719, gi\|... - gi\|89109719\|ref\|AP_003499.1\| methionine adenosyltransferase 1 [Escherichia coli str. K-12 substr. W3... gi\|208806270, gi... - gi\|208806270\|ref\|ZP_03248607.1\| S-adenosylmethionine synthetase [Escherichia coli O157:H7 str. EC420... METK_ECO24 - S-adenosylmethionine synthase OS=Escherichia coli O139:H28 (strain E24377A / ETEC) GN=metK PE=3 SV=1 METK_ECOHS - S-adenosylmethionine synthase OS=Escherichia coli O9:H4 (strain HS) GN=metK PE=3 SV=1 METK_ECOL6 - S-adenosylmethionine synthase OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) GN=metK... gi\|194436893, gi... - gi\|83587660\|ref\|ZP_00926287.1\| COG0192: S-adenosylmethionine synthetase [Escherichia coli 101-1], gi... gi\|162138378 - gi\|162138378\|ref\|YP_542310.2\| S-adenosylmethionine synthetase [Escherichia coli UTI89] gi\|192959310, gi... - gi\|75239488\|ref\|ZP_00723459.1\| COG0192: S-adenosylmethionine synthetase [Escherichia coli E110019], ... gi\|188017763, gi... - gi\|188017763\|gb\|EDU55885.1\| S-adenosylmethionine synthetase [Escherichia coli O157:H7 str. EC4113], ... gi\|190907904, gi... - gi\|75241262\|ref\|ZP_00725124.1\| COG0192: S-adenosylmethionine synthetase [Escherichia coli F11], gi\|1... gi\|189358493, gi... - gi\|189358493\|gb\|EDU76912.1\| S-adenosylmethionine synthetase [Escherichia coli O157:H7 str. EC4401], ... gi\|194415755, gi... - gi\|75212436\|ref\|ZP_00712460.1\| COG0192: S-adenosylmethionine synthetase [Escherichia coli B171], gi\|... gi\|189369445, gi... - gi\|189369445\|gb\|EDU87861.1\| S-adenosylmethionine synthetase [Escherichia coli O157:H7 str. EC4501], ... gi\|75228896, gi\|... - gi\|75228896\|ref\|ZP_00715493.1\| COG0192: S-adenosylmethionine synthetase [Escherichia coli B7A], gi\|1... gi\|168766948, gi... - gi\|189363617\|gb\|EDU82036.1\| S-adenosylmethionine synthetase [Escherichia coli O157:H7 str. EC4486], ... METK_ECO55 - S-adenosylmethionine synthase OS=Escherichia coli (strain 55989 / EAEC) GN=metK PE=3 SV=1 METK_ECO7I - S-adenosylmethionine synthase OS=Escherichia coli O7:K1 (strain IAI39 / ExPEC) GN=metK PE=3 SV=1 METK_ECOLU - S-adenosylmethionine synthase OS=Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC) GN=metK PE=3 S... EG10589 - S-adenosylmethionine synthetase / S-adenosylmethionine synthase; methionine adenosyltransferase; eth... gi\|208734303, gi... - gi\|208813026\|ref\|ZP_03254355.1\| S-adenosylmethionine synthetase [Escherichia coli O157:H7 str. EC404... gi\|208821064, gi... - gi\|208821064\|ref\|ZP_03261384.1\| S-adenosylmethionine synthetase [Escherichia coli O157:H7 str. EC404... METK_ECO5E - S-adenosylmethionine synthase OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) GN=metK PE=3 SV=1 METK_ECOSE - S-adenosylmethionine synthase OS=Escherichia coli (strain SE11) GN=metK PE=3 SV=1 METK_ECO27 - S-adenosylmethionine synthase OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=metK PE=3 SV=1 METK_ECO8A - S-adenosylmethionine synthase OS=Escherichia coli O8 (strain IAI1) GN=metK PE=3 SV=1 gi\|218366702, gi... - gi\|218559933\|ref\|YP_002392846.1\| S-adenosylmethionine synthetase [Escherichia coli S88], gi\|21836670... gi\|254594294, gi... - gi\|254794894\|ref\|YP_003079731.1\| methionine adenosyltransferase 1 [Escherichia coli O157:H7 str. TW1... gi\|218691066, gi... - gi\|218691066\|ref\|YP_002399278.1\| S-adenosylmethionine synthetase [Escherichia coli ED1a], gi\|2184286... gi\|253974753, gi... - gi\|254162852\|ref\|YP_003045960.1\| S-adenosylmethionine synthetase [Escherichia coli B str. REL606], g... METK_ECOLI - S-adenosylmethionine synthetase (EC 2.5.1.6) (Methionine adenosyltransferase) (AdoMet synthetase) (M... METK_SHIFL - S-adenosylmethionine synthase OS=Shigella flexneri GN=metK PE=3 SV=2 METK_ECO57 - S-adenosylmethionine synthase OS=Escherichia coli O157:H7 GN=metK PE=3 SV=2 gi\|30064258, gi\|... - gi\|30064258\|ref\|NP_838429.1\| S-adenosylmethionine synthetase [Shigella flexneri 2a str. 2457T], gi\|3... gi\|12517485, gi\|... - gi\|15803481\|ref\|NP_289514.1\| S-adenosylmethionine synthetase [Escherichia coli O157:H7 EDL933], gi\|1... EG10589 - S-adenosylmethionine synthetase / S-adenosylmethionine synthase; methionine adenosyltransferase; eth... sp\|B7UHY9\|METK_ECO27 - S-adenosylmethionine synthase OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=metK PE=3 SV=1 gi\|15833072, gi\|... - gi\|15833072\|ref\|NP_311845.1\| S-adenosylmethionine synthetase [Escherichia coli O157:H7 str. Sakai], ... gi\|117625169, gi... - gi\|117625169\|ref\|YP_854157.1\| S-adenosylmethionine synthetase [Escherichia coli APEC O1], gi\|1155142... METK_ECOL5 - S-adenosylmethionine synthase OS=Escherichia coli O6:K15:H31 (strain 536 / UPEC) GN=metK PE=3 SV=1 gi\|124526158, gi... - gi\|124526158\|ref\|ZP_01698163.1\| Methionine adenosyltransferase [Escherichia coli B], gi\|124502262\|gb... METK_SHIF8 - S-adenosylmethionine synthase OS=Shigella flexneri serotype 5b (strain 8401) GN=metK PE=3 SV=1	0.0	[1..384]	[1..384]
METK_SHIB3 - S-adenosylmethionine synthase OS=Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) GN=metK PE... METK_SHIBS - S-adenosylmethionine synthase OS=Shigella boydii serotype 4 (strain Sb227) GN=metK PE=3 SV=1	0.0	[1..384]	[1..384]
METK_PHOLL - S-adenosylmethionine synthase OS=Photorhabdus luminescens subsp. laumondii GN=metK PE=3 SV=1 METK_PHOLL - S-adenosylmethionine synthase OS=Photorhabdus luminescens subsp. laumondii (strain DSM 15139 / CIP 1...	0.0	[1..384]	[1..384]
METK_ECOLI - (P0A817) S-adenosylmethionine synthetase (EC 2.5.1.6) (Methionine adenosyltransferase) (AdoMet synth... METK_SHIFL - (P0A820) S-adenosylmethionine synthetase (EC 2.5.1.6) (Methionine adenosyltransferase) (AdoMet synth... METK_ECO57 - (P0A819) S-adenosylmethionine synthetase (EC 2.5.1.6) (Methionine adenosyltransferase) (AdoMet synth... METK_ECOL6 - (P0A818) S-adenosylmethionine synthetase (EC 2.5.1.6) (Methionine adenosyltransferase) (AdoMet synth...	0.0	[2..384]	[1..383]
gi\|238798628, gi... - gi\|77961486\|ref\|ZP_00825322.1\| COG0192: S-adenosylmethionine synthetase [Yersinia mollaretii ATCC 43...	0.0	[1..384]	[1..384]
gi\|238725540, gi... - gi\|77976235\|ref\|ZP_00831745.1\| COG0192: S-adenosylmethionine synthetase [Yersinia intermedia ATCC 29...	0.0	[1..384]	[1..384]
gi\|77956703, gi\|... - gi\|77956703\|ref\|ZP_00820786.1\| COG0192: S-adenosylmethionine synthetase [Yersinia bercovieri ATCC 43...	0.0	[1..384]	[1..384]
gi\|77974474, gi\|... - gi\|77974474\|ref\|ZP_00830014.1\| COG0192: S-adenosylmethionine synthetase [Yersinia frederiksenii ATCC...	0.0	[1..384]	[1..384]
gi\|21960256, gi\|... - gi\|22127190\|ref\|NP_670613.1\| S-adenosylmethionine synthetase [Yersinia pestis KIM], gi\|21960256\|gb\|A... METK_YERPS - S-adenosylmethionine synthase OS=Yersinia pseudotuberculosis serotype I (strain IP32953) GN=metK PE=... gi\|45443250, gi\|... - gi\|45443250\|ref\|NP_994789.1\| S-adenosylmethionine synthetase [Yersinia pestis biovar Microtus str. 9... METK_YERPE - S-adenosylmethionine synthase OS=Yersinia pestis GN=metK PE=3 SV=1 gi\|115346714, gi... - gi\|218928103\|ref\|YP_002345978.1\| S-adenosylmethionine synthetase [Yersinia pestis CO92], gi\|16121235... gi\|165990834, gi... - gi\|166010348\|ref\|ZP_02231246.1\| S-adenosylmethionine synthetase [Yersinia pestis biovar Antiqua str.... METK_YERPP - S-adenosylmethionine synthase OS=Yersinia pestis (strain Pestoides F) GN=metK PE=3 SV=1 gi\|165923173, gi... - gi\|165924973\|ref\|ZP_02220805.1\| S-adenosylmethionine synthetase [Yersinia pestis biovar Orientalis s... gi\|167399744, gi... - gi\|167399744\|ref\|ZP_02305262.1\| S-adenosylmethionine synthetase [Yersinia pestis biovar Antiqua str.... gi\|166205972, gi... - gi\|166212680\|ref\|ZP_02238715.1\| S-adenosylmethionine synthetase [Yersinia pestis biovar Antiqua str.... gi\|167426700, gi... - gi\|167426700\|ref\|ZP_02318453.1\| S-adenosylmethionine synthetase [Yersinia pestis biovar Mediaevalis ... gi\|167421931, gi... - gi\|167421931\|ref\|ZP_02313684.1\| S-adenosylmethionine synthetase [Yersinia pestis biovar Orientalis s... METK_YERPB - S-adenosylmethionine synthase OS=Yersinia pseudotuberculosis serotype IB (strain PB1/+) GN=metK PE=3... gi\|229704308, gi... - gi\|229837620\|ref\|ZP_04457782.1\| methionine adenosyltransferase 1 [Yersinia pestis Pestoides A], gi\|2... METK_YERPY - S-adenosylmethionine synthase OS=Yersinia pseudotuberculosis serotype O:3 (strain YPIII) GN=metK PE=... gi\|229697213, gi... - gi\|229840847\|ref\|ZP_04461006.1\| methionine adenosyltransferase 1 [Yersinia pestis biovar Orientalis ... gi\|229842593, gi... - gi\|229842593\|ref\|ZP_04462748.1\| methionine adenosyltransferase 1 [Yersinia pestis biovar Orientalis ... gi\|149290674, gi... - gi\|149367060\|ref\|ZP_01889093.1\| S-adenosylmethionine synthetase [Yersinia pestis CA88-4125], gi\|1492... METK_YERPG - S-adenosylmethionine synthase OS=Yersinia pestis bv. Antiqua (strain Angola) GN=metK PE=3 SV=1 METK_YERP3 - S-adenosylmethionine synthase OS=Yersinia pseudotuberculosis serotype O:1b (strain IP 31758) GN=metK... METK_YERPN - S-adenosylmethionine synthase OS=Yersinia pestis bv. Antiqua (strain Nepal516) GN=metK PE=3 SV=1 METK_YERPS - S-adenosylmethionine synthase OS=Yersinia pseudotuberculosis GN=metK PE=3 SV=1 gi\|165937296, gi... - gi\|89104334\|ref\|ZP_01176880.1\| COG0192: S-adenosylmethionine synthetase [Yersinia pestis biovar Orie... METK_YERPA - S-adenosylmethionine synthase OS=Yersinia pestis bv. Antiqua (strain Antiqua) GN=metK PE=3 SV=1	0.0	[1..384]	[1..384]

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Predicted Domain #1

Region A:
Residues: [1-384]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAKHLFTSES VSEGHPDKIA DQISDAVLDA ILQQDPKARV ACETYVKTGM VLVGGEITTS  60
   61 AWVDIEEITR NTVREIGYVH SDMGFDANSC AVLSAIGKQS PDINQGVDRA DPLEQGAGDQ 120
  121 GLMFGYATNE TDVLMPAPIT YAHRLVQRQA EVRKNGTLPW LRPDAKSQVT FQYDDGKIVG 180
  181 IDAVVLSTQH AEDIDQKSLQ EAVMEEIIKP ILPSEWLNTS TKFFINPTGR FVIGGPMGDC 240
  241 GLTGRKIIVD TYGGMARHGG GAFSGKDPSK VDRSAAYAAR YVAKNIVAAG LADRCEIQVS 300
  301 YAIGVAEPTS IMVETFGTEK VPAEQLILLV REFFDLRPYG LIQMLDLLHP IYKETAAYGH 360
  361 FGRENFPWEK TDKAQLLRDA AGLK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1000.0
Match:	1fugA
Description:	S-adenosylmethionine synthetase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
methionine adenosyltransferase activity	8.00759843092519	bayes_pls_golite062009
transferase activity	1.78879119839291	bayes_pls_golite062009
binding	1.70779292877479	bayes_pls_golite062009
catalytic activity	1.59111295908728	bayes_pls_golite062009
transferase activity, transferring alkyl or aryl (other than methyl) groups	1.11999094477144	bayes_pls_golite062009
protein binding	0.298204436433395	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: