YRC Public Data Repository - Protein Structure Prediction

Protein:	LIPA_YERPG
Organism:	Yersinia pestis Angola
Length:	321 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LIPA_YERPG.

Description	E-value	Query Range	Subject Range
LIPA_VIBVY - Lipoyl synthase OS=Vibrio vulnificus (strain YJ016) GN=lipA PE=3 SV=1 LIPA_VIBVU - Lipoyl synthase OS=Vibrio vulnificus GN=lipA PE=3 SV=1 LIPA_VIBVU - Lipoyl synthase OS=Vibrio vulnificus (strain CMCP6) GN=lipA PE=3 SV=1	1.0E-73	[1..321]	[1..321]
LIPA_VIBPA - Lipoyl synthase OS=Vibrio parahaemolyticus GN=lipA PE=3 SV=1 LIPA_VIBPA - Lipoyl synthase OS=Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) GN=lipA PE=3 SV=1	5.0E-73	[1..321]	[1..321]
LIPA_VIBF1 - Lipoyl synthase OS=Vibrio fischeri (strain ATCC 700601 / ES114) GN=lipA PE=3 SV=1	9.0E-73	[1..321]	[1..321]
LIPA_VIBTL - Lipoyl synthase OS=Vibrio tasmaniensis (strain LGP32) GN=lipA PE=3 SV=1 gi\|85836660, gi\|... - gi\|86145689\|ref\|ZP_01064019.1\| lipoyl synthase [Vibrio sp. MED222], gi\|85836660\|gb\|EAQ54786.1\| lipoy...	9.0E-73	[1..321]	[1..321]
LIPA_YERE8 - Lipoyl synthase OS=Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081) GN=l... gi\|238721480, gi... - gi\|77973025\|ref\|ZP_00828578.1\| COG0320: Lipoate synthase [Yersinia frederiksenii ATCC 33641], gi\|238...	1.0E-72	[1..321]	[1..321]
LIPA_PECAS - Lipoyl synthase OS=Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) GN=lipA PE=3 SV=1 LIPA_ERWCT - Lipoyl synthase OS=Erwinia carotovora subsp. atroseptica GN=lipA PE=3 SV=1	1.0E-72	[1..321]	[1..321]
gi\|238791634, gi... - gi\|77979027\|ref\|ZP_00834449.1\| COG0320: Lipoate synthase [Yersinia intermedia ATCC 29909], gi\|238791...	1.0E-72	[1..321]	[1..321]
gi\|77962165, gi\|... - gi\|77962165\|ref\|ZP_00825989.1\| COG0320: Lipoate synthase [Yersinia mollaretii ATCC 43969], gi\|238795...	2.0E-72	[1..321]	[1..321]
gi\|229357678, gi... - gi\|229505455\|ref\|ZP_04394965.1\| lipoate synthase [Vibrio cholerae BX 330286], gi\|229357678\|gb\|EEO225... LIPA_VIBCM - Lipoyl synthase OS=Vibrio cholerae serotype O1 (strain M66-2) GN=lipA PE=3 SV=1 gi\|229339626, gi... - gi\|229523263\|ref\|ZP_04412670.1\| lipoate synthase [Vibrio cholerae TM 11079-80], gi\|229339626\|gb\|EEO0... gi\|229349855, gi... - gi\|229512962\|ref\|ZP_04402428.1\| lipoate synthase [Vibrio cholerae TMA 21], gi\|229349855\|gb\|EEO14809.... gi\|229333733, gi... - gi\|229529959\|ref\|ZP_04419349.1\| lipoate synthase [Vibrio cholerae 12129(1)], gi\|229333733\|gb\|EEN9921... gi\|229525555, gi... - gi\|229525555\|ref\|ZP_04414960.1\| lipoate synthase [Vibrio cholerae bv. albensis VL426], gi\|229339136\|... gi\|153213828, gi... - gi\|153213828\|ref\|ZP_01949034.1\| lipoic acid synthetase [Vibrio cholerae 1587], gi\|124115662\|gb\|EAY34... gi\|121548057, gi... - gi\|121587685\|ref\|ZP_01677447.1\| lipoic acid synthetase [Vibrio cholerae 2740-80], gi\|121548057\|gb\|EA... gi\|153817221, gi... - gi\|153817221\|ref\|ZP_01969888.1\| lipoic acid synthetase [Vibrio cholerae NCTC 8457], gi\|126512255\|gb\|... gi\|124118405, gi... - gi\|153223154\|ref\|ZP_01953692.1\| lipoic acid synthetase [Vibrio cholerae MAK 757], gi\|124118405\|gb\|EA... LIPA_VIBC3 - Lipoyl synthase OS=Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395) GN=l... gi\|75816444, gi\|... - gi\|75816444\|ref\|ZP_00746914.1\| COG0320: Lipoate synthase [Vibrio cholerae V52], gi\|121728058\|ref\|ZP_... gi\|150424477, gi... - gi\|254285615\|ref\|ZP_04960579.1\| lipoic acid synthetase [Vibrio cholerae AM-19226], gi\|197753052\|ref\|... gi\|148875554, gi... - gi\|153828938\|ref\|ZP_01981605.1\| lipoic acid synthetase [Vibrio cholerae 623-39], gi\|148875554\|gb\|EDL... gi\|149740162, gi... - gi\|153826139\|ref\|ZP_01978806.1\| lipoic acid synthetase [Vibrio cholerae MZO-2], gi\|149740162\|gb\|EDM5... tr\|A0A085SV12\|A0... - Lipoyl synthase OS=Vibrio cholerae GN=lipA PE=3 SV=1	3.0E-72	[1..321]	[1..321]
gi\|84377037, gi\|... - gi\|84388973\|ref\|ZP_00991181.1\| lipoyl synthase [Vibrio splendidus 12B01], gi\|84377037\|gb\|EAP93909.1\|...	3.0E-72	[1..321]	[1..321]

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Predicted Domain #1

Region A:
Residues: [1-321]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKPIQMERG VKYRDADKMA LIPVKNVVTE RQELLRKPEW LKIKLPTDSS RIQGIKAAMR  60
   61 KNGLHSVCEE ASCPNLSECF NHGTATFMIL GAICTRRCPF CDVAHGRPVT PDANEPEKLA 120
  121 QTIQDMGLRY VVITSVDRDD LRDGGAQHFA DCISAIRAKN PTIKIETLVP DFRGRMDRAL 180
  181 DILTATPPDV FNHNLENVPR VYRQVRPGAN YDWSLKLLER FKEAHPDIPT KSGLMVGLGE 240
  241 TNAEIVEVMH DLRRHGVTML TLGQYLQPSR HHLPVQRYVS PAEFDEMKAE AMAMGFTHAA 300
  301 CGPFVRSSYH ADLQAKGMEV K

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	45.0
Match:	1r30A
Description:	The Crystal Structure of Biotin Synthase, an S-Adenosylmethionine-Dependent Radical Enzyme
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
biotin synthase activity	2.22585029668171	bayes_pls_golite062009
radical SAM enzyme activity	2.08127882819276	bayes_pls_golite062009
catalytic activity	1.85375915825216	bayes_pls_golite062009
coproporphyrinogen oxidase activity	1.27516985221578	bayes_pls_golite062009
sulfurtransferase activity	1.26112752511053	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor	0.604275066192139	bayes_pls_golite062009
transferase activity, transferring sulfur-containing groups	0.35292941647096	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: