YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|121629969, gi...
Organism:	Vibrio cholerae V52
Length:	276 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|121629969, gi....

Description	E-value	Query Range	Subject Range
gi\|89082243, gi\|... - gi\|89093553\|ref\|ZP_01166501.1\| NAD(+) synthetase [Oceanospirillum sp. MED92], gi\|89082243\|gb\|EAR6146...	259.0	[0..5]	[276..6]
NADE_BACHD - NH(3)-dependent NAD(+) synthetase OS=Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 734... NADE_BACHD - NH(3)-dependent NAD(+) synthetase OS=Bacillus halodurans GN=nadE PE=3 SV=1	256.0	[0..1]	[276..1]
gi\|91223365, gi\|... - gi\|91223365\|ref\|ZP_01258631.1\| NAD synthetase [Vibrio alginolyticus 12G01], gi\|91192178\|gb\|EAS78441....	252.0	[0..1]	[276..1]
gi\|194539825, gi... - gi\|75856650\|ref\|ZP_00764275.1\| COG0171: NAD synthase [Vibrio sp. Ex25], gi\|254229089\|ref\|ZP_04922509...	252.0	[0..1]	[276..1]
gi\|84385297, gi\|... - gi\|84385297\|ref\|ZP_00988329.1\| NAD(+) synthetase [Vibrio splendidus 12B01], gi\|84379894\|gb\|EAP96745....	252.0	[0..1]	[276..1]
NADE_VIBPA - NH(3)-dependent NAD(+) synthetase OS=Vibrio parahaemolyticus GN=nadE PE=3 SV=1 NADE_VIBPA - NH(3)-dependent NAD(+) synthetase OS=Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) GN...	251.0	[0..1]	[276..1]
NADE_VIBVY - NH(3)-dependent NAD(+) synthetase OS=Vibrio vulnificus (strain YJ016) GN=nadE PE=3 SV=1	251.0	[0..1]	[276..1]
gi\|86144504, gi\|... - gi\|86144504\|ref\|ZP_01062836.1\| NAD(+) synthetase [Vibrio sp. MED222], gi\|85837403\|gb\|EAQ55515.1\| NAD...	250.0	[0..1]	[276..1]
NADE_VIBVU - NH(3)-dependent NAD(+) synthetase OS=Vibrio vulnificus GN=nadE PE=3 SV=1 NADE_VIBVU - NH(3)-dependent NAD(+) synthetase OS=Vibrio vulnificus (strain CMCP6) GN=nadE PE=3 SV=1	250.0	[0..1]	[276..1]
NADE_SHEON - NH(3)-dependent NAD(+) synthetase OS=Shewanella oneidensis (strain MR-1) GN=nadE PE=3 SV=1 SO2021 - NH(3)-dependent NAD(+) synthetase	250.0	[0..1]	[276..1]

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Predicted Domain #1

Region A:
Residues: [1-276]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEHKIREEMR VLPSIDPQFE IERRVAFIKR KLTEARCKSL VLGISGGVDS TTCGRLAQLA  60
   61 VEELNQQHNT TEYQFIAVRL PYGEQKDEDE AQLALSFIRP THSVSVNIKA GVDGLHAASH 120
  121 HALANTGLIP SDPAKVDFIK GNVKARARMV AQYEIAGYVG GLVLGTDHSA ENITGFYTKF 180
  181 GDGACDLAPL FGLNKRQVRL LAKTLGAPEQ LVYKTPTADL EELAPQKADE AALNLTYEQI 240
  241 DDFLEGKAVP AEVSQRLVAI YHATQHKRQP IPTIYD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	64.09691
Match:	1wxeA
Description:	E.coli NAD Synthetase, AMP
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ligase activity, forming carbon-nitrogen bonds	1.9422825865652	bayes_pls_golite062009
carbon-nitrogen ligase activity, with glutamine as amido-N-donor	1.77152913449838	bayes_pls_golite062009
GMP synthase (glutamine-hydrolyzing) activity	1.08094655947236	bayes_pls_golite062009
ligase activity	1.02544349488516	bayes_pls_golite062009
catalytic activity	0.828867994386867	bayes_pls_golite062009
NAD+ synthase activity	0.693146657234538	bayes_pls_golite062009
binding	0.268276895381766	bayes_pls_golite062009
protein binding	0.0198162482538781	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: