YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|123993581, gi...
Organism:	synthetic construct
Length:	281 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|123993581, gi....

Description	E-value	Query Range	Subject Range
gi\|60830321 - gi\|60830321\|gb\|AAX36923.1\| tumor necrosis factor superfamily member 6 [synthetic construct]	1.0E-94	[1..281]	[1..281]
gi\|61658441 - gi\|61658441\|gb\|AAX49569.1\| CD95 ligand [Homo sapiens]	6.0E-94	[1..281]	[1..281]
gi\|114565468 - gi\|114565468\|ref\|XP_524967.2\| PREDICTED: fas ligand [Pan troglodytes]	1.0E-93	[1..281]	[1..280]
gi\|74136237, gi\|... - gi\|74136237\|ref\|NP_001028010.1\| FAS antigen CD95 [Macaca mulatta], gi\|13650010\|gb\|AAK37539.1\|AF34485...	2.0E-93	[1..281]	[1..280]
TNFL6_MACFA - Tumor necrosis factor ligand superfamily member 6 OS=Macaca fascicularis GN=FASLG PE=2 SV=1 TNFL6_MACMU - Tumor necrosis factor ligand superfamily member 6 OS=Macaca mulatta GN=FASLG PE=2 SV=1 TNFL6_MACNE - Tumor necrosis factor ligand superfamily member 6 OS=Macaca nemestrina GN=FASLG PE=2 SV=1	2.0E-93	[1..281]	[1..280]
TNFL6_CERAT - Tumor necrosis factor ligand superfamily member 6 OS=Cercocebus atys GN=FASLG PE=2 SV=1	4.0E-93	[1..281]	[1..280]
TNFL6_FELCA - Tumor necrosis factor ligand superfamily member 6 OS=Felis catus GN=FASLG PE=2 SV=1	4.0E-90	[1..281]	[1..280]
gi\|913760 - gi\|913760\|gb\|AAB33780.1\| Fas ligand; FasL [Mus sp.] TNFL6_MOUSE - Tumor necrosis factor ligand superfamily member 6 OS=Mus musculus GN=Faslg PE=1 SV=1	1.0E-89	[1..281]	[1..279]

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Predicted Domain #1

Region A:
Residues: [1-85]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQQPFNYPYP QIYWVDSSAS SPWAPPGTVL PCPTSVPRRP GQRRPPPPPP PPPLPPPPPP  60
   61 PPLPPLPLPP LKKRGNHSTG LCLLV

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [86-281]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFFMVLVALV GLGLGMFQLF HLQKELAELR ESTSQMHTAS SLEKQIGHPS PPPEKKELRK  60
   61 VAHLTGKSNS RSMPLEWEDT YGIVLLSGVK YKKGGLVINE TGLYFVYSKV YFRGQSCNNL 120
  121 PLSHKVYMRN SKYPQDLVMM EGKMMSYCTT GQMWARSSYL GAVFNLTSAD HLYVNVSELS 180
  181 LVNFEESQTF FGLYKL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	39.39794
Match:	1dg6A
Description:	Apoptosis-2 ligand, apo2l/TRAIL
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
receptor binding	3.37824597039547	bayes_pls_golite062009
tumor necrosis factor receptor superfamily binding	2.2657673851253	bayes_pls_golite062009
protein binding	2.25413201891408	bayes_pls_golite062009
binding	1.55055236820725	bayes_pls_golite062009
tumor necrosis factor receptor binding	1.07319043778379	bayes_pls_golite062009
cytokine activity	0.82341093302063	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: