YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|61358634, gi\|...
Organism:	synthetic construct
Length:	364 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|61358634, gi|....

Description	E-value	Query Range	Subject Range
gi\|61368727, gi\|... - gi\|61368727\|gb\|AAX43227.1\| transcription factor-like 1 [synthetic construct], gi\|54695580\|gb\|AAV3816...	1.0E-96	[1..364]	[1..364]
gi\|109467177, gi... - gi\|34858037\|ref\|XP_227428.2\| PREDICTED: similar to Vacuolar protein sorting protein 72 homolog (Prot...	2.0E-96	[1..364]	[1..364]
VPS72_PONPY - Vacuolar protein sorting-associated protein 72 homolog - Pongo pygmaeus (Orangutan) VPS72_PONAB - Vacuolar protein sorting-associated protein 72 homolog OS=Pongo abelii GN=VPS72 PE=2 SV=1	6.0E-96	[1..364]	[1..364]
gi\|57098805 - gi\|57098805\|ref\|XP_533052.1\| PREDICTED: similar to YL-1 protein (Transcription factor-like 1) [Canis...	7.0E-96	[1..364]	[1..364]
gi\|62897437, gi\|... - gi\|62897437\|dbj\|BAD96659.1\| transcription factor-like 1 variant [Homo sapiens], gi\|62897429\|dbj\|BAD9...	7.0E-96	[1..364]	[1..364]
gi\|109016140 - gi\|109016140\|ref\|XP_001104866.1\| PREDICTED: transcription factor-like 1 [Macaca mulatta] gi\|163781015 - gi\|163781015\|gb\|ABY40791.1\| vacuolar protein sorting 72 homolog (predicted) [Papio anubis]	6.0E-95	[1..364]	[1..364]
VPS72_BOVIN - Vacuolar protein sorting-associated protein 72 homolog OS=Bos taurus GN=VPS72 PE=2 SV=1	2.0E-93	[1..364]	[1..364]
YL1_MOUSE - (Q62481) YL-1 protein (Transcription factor-like 1)	7.0E-92	[1..364]	[1..368]

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Predicted Domain #1

Region A:
Residues: [1-244]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLAGGRAPR KTAGNRLSGL LEAEEEDEFY QTTYGGFTEE SGDDEYQGDQ SDTEDEVDSD  60
   61 FDIDEGDEPS SDGEAEEPRR KRRVVTKAYK EPLKSLRPRK VNTPAGSSQK AREEKALLPL 120
  121 ELQDDGSDSR KSMRQSTAEH TRQTFLRVQE RQGQSRRRKG PHCERPLTQE ELLREAKITE 180
  181 ELNLRSLETY ERLEADKKKQ VHKKRKCPGP IITYHSVTVP LVGEPGPKEE NVDIEGLDPA 240
  241 PSVS

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.07
Match:	1rw6A
Description:	human APP core domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	2.91859588671053	bayes_pls_golite062009
nucleic acid binding	2.76287385741172	bayes_pls_golite062009
DNA binding	2.7437155216718	bayes_pls_golite062009
protein binding	1.72899821979103	bayes_pls_golite062009
identical protein binding	0.715609885862042	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [245-364]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ALTPHAGTGP VNPPARCSRT FITFSDDATF EEWFPQGRPP KVPVREVCPV THRPALYRDP  60
   61 VTDIPYATAR AFKIIREAYK KYITAHGLPP TASALGPGPP PPEPLPGSGP RALRQKIVIK 120
  121

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: