YRC Public Data Repository - Protein Structure Prediction

Protein:	COOS2_CARHZ
Organism:	Carboxydothermus hydrogenoformans Z-2901
Length:	636 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for COOS2_CARHZ.

Description	E-value	Query Range	Subject Range
gi\|38257762, gi\|... - sp\|Q9F8A8\|COS2_CARHY Carbon monoxide dehydrogenase 2 (CODH 2), gi\|11095246\|gb\|AAG29809.1\|AF249899_2 ...	773.0	[0..1]	[635..1]
gi\|72398121, gi\|... - gi\|73670959\|ref\|YP_306974.1\| carbon monoxide dehydrogenase [Methanosarcina barkeri str. Fusaro], gi\|...	760.0	[0..7]	[634..8]
gi\|77996167, gi\|... - gi\|78044052\|ref\|YP_359590.1\| carbon-monoxide dehydrogenase, catalytic subunit [Carboxydothermus hydr...	759.0	[0..1]	[634..1]
COOS1_METAC - Carbon monoxide dehydrogenase 1 OS=Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12... COS1_METAC, COOS... - (Q8TKW2) Carbon monoxide dehydrogenase 1 (EC 1.2.99.2) (CODH 1), Carbon monoxide dehydrogenase 1 OS=...	753.0	[0..7]	[634..12]
COOS1_METMA - Carbon monoxide dehydrogenase 1 OS=Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1... COS1_METMA, COOS... - (Q8Q0L5) Carbon monoxide dehydrogenase 1 (EC 1.2.99.2) (CODH 1), Carbon monoxide dehydrogenase 1 OS=...	750.0	[0..7]	[634..12]
gi\|68169509, gi\|... - gi\|68206615\|ref\|ZP_00558799.1\| Carbon-monoxide dehydrogenase, catalytic subunit [Desulfitobacterium ...	741.0	[0..5]	[634..3]
gi\|39984086, gi\|... - gi\|39997196\|ref\|NP_953147.1\| carbon monoxide dehydrogenase subunit [Geobacter sulfurreducens PCA], g...	740.0	[0..7]	[634..11]
gi\|89336636, gi\|... - gi\|89897188\|ref\|YP_520675.1\| carbon monoxide dehydrogenase [Desulfitobacterium hafniense Y51], gi\|89...	739.0	[0..5]	[634..6]

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Predicted Domain #1

Region A:
Residues: [1-636]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAKQNLKSTD RAVQQMLDKA KREGIQTVWD RYEAMKPQCG FGETGLCCRH CLQGPCRINP  60
   61 FGDEPKVGIC GATAEVIVAR GLDRSIAAGA AGHSGHAKHL AHTLKKAVQG KAASYMIKDR 120
  121 TKLHSIAKRL GIPTEGQKDE DIALEVAKAA LADFHEKDTP VLWVTTVLPP SRVKVLSAHG 180
  181 LIPAGIDHEI AEIMHRTSMG CDADAQNLLL GGLRCSLADL AGCYMGTDLA DILFGTPAPV 240
  241 VTESNLGVLK ADAVNVAVHG HNPVLSDIIV SVSKEMENEA RAAGATGINV VGICCTGNEV 300
  301 LMRHGIPACT HSVSQEMAMI TGALDAMILD YQCIQPSVAT IAECTGTTVI TTMEMSKITG 360
  361 ATHVNFAEEA AVENAKQILR LAIDTFKRRK GKPVEIPNIK TKVVAGFSTE AIINALSKLN 420
  421 ANDPLKPLID NVVNGNIRGV CLFAGCNNVK VPQDQNFTTI ARKLLKQNVL VVATGCGAGA 480
  481 LMRHGFMDPA NVDELCGDGL KAVLTAIGEA NGLGGPLPPV LHMGSCVDNS RAVALVAALA 540
  541 NRLGVDLDRL PVVASAAEAM HEKAVAIGTW AVTIGLPTHI GVLPPITGSL PVTQILTSSV 600
  601 KDITGGYFIV ELDPETAADK LLAAINERRA GLGLPW

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1000.0
Match:	1su6A
Description:	Carbon monoxide dehydrogenase from Carboxydothermus hydrogenoformans: CO reduced state
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
carbon-monoxide dehydrogenase (acceptor) activity	2.71170968542992	bayes_pls_golite062009
catalytic activity	1.62887824627302	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	0.78837729116788	bayes_pls_golite062009
oxidoreductase activity	0.59225440851574	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: