YRC Public Data Repository - Protein Structure Prediction

Protein:	THYX_GEOSL
Organism:	Geobacter sulfurreducens
Length:	232 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for THYX_GEOSL.

Description	E-value	Query Range	Subject Range
gi\|78192854, gi\|... - gi\|78221599\|ref\|YP_383346.1\| FAD-dependent thymidylate synthase [Geobacter metallireducens GS-15], g...	304.0	[0..1]	[232..1]
gi\|168214714, gi... - gi\|170713810\|gb\|EDT25992.1\| thymidylate synthase, flavin-dependent [Clostridium perfringens CPE str.... gi\|182380042, gi... - gi\|182380042\|gb\|EDT77521.1\| thymidylate synthase, flavin-dependent [Clostridium perfringens NCTC 823... gi\|169297747, gi... - gi\|169344136\|ref\|ZP_02865119.1\| thymidylate synthase, flavin-dependent [Clostridium perfringens C st... gi\|182626994, gi... - gi\|182626994\|ref\|ZP_02954724.1\| thymidylate synthase, flavin-dependent [Clostridium perfringens D st... THYX_CLOPE - Thymidylate synthase ThyX OS=Clostridium perfringens (strain 13 / Type A) GN=thyX PE=3 SV=1 gi\|170661745, gi... - gi\|170661745\|gb\|EDT14428.1\| thymidylate synthase, flavin-dependent [Clostridium perfringens E str. J... gi\|170710771, gi... - gi\|170710771\|gb\|EDT22953.1\| thymidylate synthase, flavin-dependent [Clostridium perfringens B str. A... gi\|110801337, gi... - gi\|110801337\|ref\|YP_697114.1\| FAD-dependent thymidylate synthase [Clostridium perfringens ATCC 13124... THYX_CLOPE - Thymidylate synthase thyX OS=Clostridium perfringens GN=thyX PE=3 SV=1	293.0	[0..1]	[227..2]
gi\|110803744, gi... - gi\|110803744\|ref\|YP_699683.1\| FAD-dependent thymidylate synthase [Clostridium perfringens SM101], gi...	290.0	[0..1]	[227..2]
gi\|115249057, gi... - gi\|126697620\|ref\|YP_001086517.1\| FAD-dependent thymidylate synthase [Clostridium difficile 630], gi\|... gi\|255099213 - gi\|255099213\|ref\|ZP_05328190.1\| FAD-dependent thymidylate synthase [Clostridium difficile QCD-63q42] gi\|255304996 - gi\|255304996\|ref\|ZP_05349168.1\| FAD-dependent thymidylate synthase [Clostridium difficile ATCC 43255... gi\|255654142 - gi\|255654142\|ref\|ZP_05399551.1\| FAD-dependent thymidylate synthase [Clostridium difficile QCD-23m63]	290.0	[0..1]	[230..1]
gi\|110547969, gi... - gi\|222053786\|ref\|YP_002536148.1\| thymidylate synthase, flavin-dependent [Geobacter sp. FRC-32], gi\|2...	289.0	[0..1]	[230..1]
THYX_CLOTE - Thymidylate synthase ThyX OS=Clostridium tetani (strain Massachusetts / E88) GN=thyX PE=3 SV=1 THYX_CLOTE - Thymidylate synthase thyX OS=Clostridium tetani GN=thyX PE=3 SV=1	285.0	[0..1]	[227..8]
gi\|88936613, gi\|... - gi\|88936613\|ref\|ZP_01142218.1\| Thymidylate synthase complementing protein ThyX [Geobacter uraniumred...	281.0	[0..1]	[229..1]
gi\|89332643, gi\|... - gi\|89893195\|ref\|YP_516682.1\| FAD-dependent thymidylate synthase [Desulfitobacterium hafniense Y51], ... gi\|23121815, gi\|... - gi\|68209503\|ref\|ZP_00561497.1\| Thymidylate synthase complementing protein [Desulfitobacterium hafnie...	279.0	[0..1]	[232..1]
gi\|77546367, gi\|... - gi\|77920284\|ref\|YP_358099.1\| FAD-dependent thymidylate synthase [Pelobacter carbinolicus DSM 2380], ...	276.0	[0..1]	[230..1]
gi\|95134915, gi\|... - gi\|95929014\|ref\|ZP_01311759.1\| Thymidylate synthase (FAD) [Desulfuromonas acetoxidans DSM 684], gi\|9...	274.0	[0..1]	[227..1]

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Predicted Domain #1

Region A:
Residues: [1-232]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKIALLQHTP DPEAAVALAA RLCYASVGID ELREKLSASD VTAFLDKIMS LGHQSVLEHA  60
   61 SFTFGIEGIS RAASHQLVRH RIASYSQQSQ RYVTFRGDGF PRVVPGSVSA TEKRRQVFES 120
  121 AMQACADAYR ALVDDGVPAE DARFVLPNAA ETKIIVTMNA RELIHFFGLR CCERAQWEIR 180
  181 ALAVEMLRLV KGVAPTIFRD AGPGCLTGPC PEGGMTCGKA AEVKRLFREM SI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	56.69897
Match:	2af6A
Description:	Crystal structure of Mycobacterium tuberculosis Flavin dependent thymidylate synthase (Mtb ThyX) in the presence of co-factor FAD and substrate analog 5-Bromo-2'-Deoxyuridine-5'-Monophosphate (BrdUMP)
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits