YRC Public Data Repository - Protein Structure Prediction

Protein:	LYAR
Organism:	Homo sapiens
Length:	379 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LYAR.

Description	E-value	Query Range	Subject Range
gi\|114593035, gi... - gi\|114593035\|ref\|XP_001153843.1\| PREDICTED: hypothetical protein FLJ20425 isoform 2 [Pan troglodytes...	1.0E-46	[1..379]	[1..379]
gi\|16041815, gi\|... - gi\|8923398\|ref\|NP_060286.1\| Ly1 antibody reactive homolog [Homo sapiens], gi\|7020518\|dbj\|BAA91162.1\|... HGNC:26021\|Ensem... - antibody reactive homolog (mouse) gi\|208965202 - gi\|208965202\|dbj\|BAG72615.1\| Ly1 antibody reactive homolog [synthetic construct]	3.0E-46	[1..379]	[1..379]
gi\|109073735, gi... - gi\|109073735\|ref\|XP_001096901.1\| PREDICTED: hypothetical protein FLJ20425 isoform 3 [Macaca mulatta]...	1.0E-45	[1..379]	[1..379]
gi\|67971354 - gi\|67971354\|dbj\|BAE02019.1\| unnamed protein product [Macaca fascicularis]	4.0E-45	[1..379]	[1..379]
LYAR_RAT - Cell growth-regulating nucleolar protein OS=Rattus norvegicus GN=Lyar PE=2 SV=1	1.0E-42	[1..379]	[1..386]
gi\|13384622, gi\|... - gi\|13384622\|ref\|NP_079557.1\| Ly1 antibody reactive clone [Mus musculus], gi\|12839441\|dbj\|BAB24554.1\|...	2.0E-42	[1..379]	[1..388]
LYAR_MOUSE - (Q08288) Cell growth regulating nucleolar protein gi\|300372 - gi\|300372\|gb\|AAB26644.1\| LYAR [Mus sp.]	7.0E-42	[1..379]	[1..388]
gi\|61554339, gi\|... - gi\|76620347\|ref\|XP_607845.2\| PREDICTED: hypothetical protein LOC537667 isoform 1 [Bos taurus], gi\|72...	6.0E-40	[1..367]	[1..370]

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Predicted Domain #1

Region A:
Residues: [1-68]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVFFTCNACG ESVKKIQVEK HVSVCRNCEC LSCIDCGKDF WGDDYKNHVK CISEDQKYGG  60
   61 KGYEGKTH

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	25.0
Match:	1wjvA
Description:	Solution structure of the N-terminal zinc finger domain of mouse cell growth regulating nucleolar protein LYAR
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	0.414217765611205	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [69-182]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KGDIKQQAWI QKISELIKRP NVSPKVRELL EQISAFDNVP RKKAKFQNWM KNSLKVHNES  60
   61 ILDQVWNIFS EASNSEPVNK EQDQRPLHPV ANPHAEISTK VPASKVKDAV EQQG

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [183-379]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EVKKNKRERK EERQKKRKRE KKELKLENHQ ENSRNQKPKK RKKGQEADLE AGGEEVPEAN  60
   61 GSAGKRSKKK KQRKDSASEE EAHVGAGKRK RRHSEVETDS KKKKMKLPEH PEGGEPEDDE 120
  121 APAKGKFNWK GTIKAILKQA PDNEITIKKL RKKVLAQYYT VTDEHHRSEE ELLVIFNKKI 180
  181 SKNPTFKLLK DKVKLVK

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: