YRC Public Data Repository - Protein Structure Prediction

Protein:	HMP_RALEU
Organism:	Cupriavidus necator
Length:	403 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HMP_RALEU.

Description	E-value	Query Range	Subject Range
gi\|113724938, gi... - gi\|150377361\|ref\|YP_001313956.1\| nitric oxide dioxygenase [Sinorhizobium medicae WSM419], gi\|1500319...	347.0	[0..1]	[403..1]
HMP_RHIME - Flavohemoprotein OS=Rhizobium meliloti GN=hmp PE=3 SV=2 HMP_RHIME - Flavohemoprotein OS=Rhizobium meliloti (strain 1021) GN=hmp PE=3 SV=2	345.0	[0..1]	[403..1]
gi\|33089388 - gi\|33089388\|gb\|AAP93662.1\| flavohemoglobin [Sinorhizobium meliloti]	339.0	[0..1]	[403..1]
gi\|32527202, gi\|... - gi\|38637864\|ref\|NP_942838.1\| flavohemoprotein [Cupriavidus necator], gi\|32527202\|gb\|AAP85952.1\| flav... HMP_CUPNH - Flavohemoprotein OS=Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) GN=hmp PE=...	339.0	[0..1]	[403..1]
HMP_BACHD - Flavohemoprotein OS=Bacillus halodurans GN=hmp PE=3 SV=1 HMP_BACHD - Flavohemoprotein OS=Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-...	338.0	[0..2]	[399..6]
gi\|52002629, gi\|... - gi\|52784778\|ref\|YP_090607.1\| Hmp [Bacillus licheniformis ATCC 14580], gi\|52347280\|gb\|AAU39914.1\| Hmp...	335.0	[0..1]	[403..1]
gi\|70983767, gi\|... - gi\|70983767\|ref\|XP_747410.1\| flavohemoprotein [Aspergillus fumigatus Af293], gi\|66845036\|gb\|EAL85372...	332.0	[0..2]	[401..31]
gi\|46324061, gi\|... - gi\|67543014\|ref\|ZP_00420948.1\| Globin:Oxidoreductase FAD/NAD(P)-binding:Oxidoreductase FAD-binding r...	331.0	[0..1]	[403..1]
gi\|56908365, gi\|... - gi\|56962130\|ref\|YP_173853.1\| nitric oxide dioxygenase [Bacillus clausii KSM-K16], gi\|56908365\|dbj\|BA...	330.0	[0..1]	[399..5]
HMP_BACC1 - Flavohemoprotein OS=Bacillus cereus (strain ATCC 10987 / NRS 248) GN=hmp PE=3 SV=1	327.0	[0..1]	[403..1]

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Predicted Domain #1

Region A:
Residues: [1-403]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLTQKTKDIV KATAPVLAEH GYDIIKCFYQ RMFEAHPELK NVFNMAHQEQ GQQQQALARA  60
   61 VYAYAENIED PNSLMAVLKN IANKHASLGV KPEQYPIVGE HLLAAIKEVL GNAATDDIIS 120
  121 AWAQAYGNLA DVLMGMESEL YERSAEQPGG WKGWRTFVIR EKRPESDVIT SFILEPADGG 180
  181 PVVNFEPGQY TSVAIDVPAL GLQQIRQYSL SDMPNGRTYR ISVKREGGGP QPPGYVSNLL 240
  241 HDHVNVGDQV KLAAPYGSFH IDVDAKTPIV LISGGVGLTP MVSMLKVALQ APPRQVVFVH 300
  301 GARNSAVHAM RDRLREAAKT YENLDLFVFY DQPLPEDVQG RDYDYPGLVD VKQIEKSILL 360
  361 PDADYYICGP IPFMRMQHDA LKNLGIHEAR IHYEVFGPDL FAE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	93.30103
Match:	1cqxA
Description:	Flavohemoglobin, N-terminal domain; Flavohemoglobin, central domain; Flavohemoglobin, C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
oxygen transporter activity	7.81281381234264	bayes_pls_golite062009
oxygen binding	3.78522064312431	bayes_pls_golite062009
hemoglobin binding	3.17505496298935	bayes_pls_golite062009
transporter activity	2.77225108027137	bayes_pls_golite062009
substrate-specific transporter activity	2.44807175467553	bayes_pls_golite062009
binding	1.56341797572673	bayes_pls_golite062009
catalytic activity	1.45374095556065	bayes_pls_golite062009
hemoglobin alpha binding	1.07662870695556	bayes_pls_golite062009
nitric-oxide synthase activity	0.943011064240739	bayes_pls_golite062009
transferase activity	0.708491789248912	bayes_pls_golite062009
riboflavin synthase activity	0.366634814975673	bayes_pls_golite062009
cofactor binding	0.365255270036622	bayes_pls_golite062009
oxidoreductase activity	0.27336340260908	bayes_pls_golite062009
coenzyme binding	0.270924422726986	bayes_pls_golite062009
protein binding	0.144900113694048	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: