YRC Public Data Repository - Protein Structure Prediction

Protein:	HEM6_SHIFL
Organism:	Shigella flexneri
Length:	299 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HEM6_SHIFL.

Description	E-value	Query Range	Subject Range
gi\|75240094 - gi\|75240094\|ref\|ZP_00724053.1\| COG0408: Coproporphyrinogen III oxidase [Escherichia coli F11] gi\|91073348, gi\|... - gi\|91211774\|ref\|YP_541760.1\| coproporphyrinogen III oxidase [Escherichia coli UTI89], gi\|91073348\|gb... gi\|26248812, gi\|... - gi\|26248812\|ref\|NP_754852.1\| coproporphyrinogen III oxidase [Escherichia coli CFT073], gi\|26109218\|g... gi\|226901325, gi... - gi\|237704959\|ref\|ZP_04535440.1\| coproporphyrinogen III oxidase [Escherichia sp. 3_2_53FAA], gi\|22690...	551.0	[0..1]	[298..2]
HEM6_ECOK1 - Oxygen-dependent coproporphyrinogen-III oxidase OS=Escherichia coli O1:K1 / APEC GN=hemF PE=3 SV=1 HEM6_ECO45 - Oxygen-dependent coproporphyrinogen-III oxidase OS=Escherichia coli O45:K1 (strain S88 / ExPEC) GN=h... HEM6_ECO27 - Oxygen-dependent coproporphyrinogen-III oxidase OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC)... gi\|227887481, gi... - gi\|227887481\|ref\|ZP_04005286.1\| coproporphyrinogen III oxidase [Escherichia coli 83972], gi\|22783583... HEM6_ECOL6 - Oxygen-dependent coproporphyrinogen-III oxidase OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 7009... HEM6_ECO81 - Oxygen-dependent coproporphyrinogen-III oxidase OS=Escherichia coli O81 (strain ED1a) GN=hemF PE=3 S... HEM6_ECOL5 - Oxygen-dependent coproporphyrinogen-III oxidase OS=Escherichia coli O6:K15:H31 (strain 536 / UPEC) G... gi\|190906764, gi... - gi\|191172900\|ref\|ZP_03034435.1\| coproporphyrinogen III oxidase, aerobic [Escherichia coli F11], gi\|1... sp\|B7UGD5\|HEM6_ECO27 - Coproporphyrinogen-III oxidase, aerobic OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=hemF... HEM6_ECOL6 - Coproporphyrinogen-III oxidase, aerobic OS=Escherichia coli O6 GN=hemF PE=3 SV=2	550.0	[0..1]	[298..1]
HEM6_SHIF8 - Oxygen-dependent coproporphyrinogen-III oxidase OS=Shigella flexneri serotype 5b (strain 8401) GN=he...	550.0	[0..1]	[298..1]
EG12189 - coproporphyrinogen III oxidase / Coproporphyrinogen III oxidase, oxygen-dependent; stimulated by man... HEM6_ECODH - Oxygen-dependent coproporphyrinogen-III oxidase OS=Escherichia coli (strain K12 / DH10B) GN=hemF PE=... HEM6_ECOLI - Coproporphyrinogen 3 oxidase, aerobic (EC 1.3.3.3) (Coproporphyrinogen III oxidase, aerobic) (Coprop... gi\|1799866, gi\|8... - gi\|89109250\|ref\|AP_003030.1\| coproporphyrinogen III oxidase [Escherichia coli str. K-12 substr. W311... gi\|124531850, gi... - gi\|124531850\|ref\|ZP_01701957.1\| Coproporphyrinogen oxidase [Escherichia coli B], gi\|124498333\|gb\|EAY... gi\|188489261, gi... - gi\|75515781\|ref\|ZP_00737916.1\| COG0408: Coproporphyrinogen III oxidase [Escherichia coli 53638], gi\|... EG12189 - coproporphyrinogen III oxidase / Coproporphyrinogen III oxidase, oxygen-dependent; stimulated by man... HEM6_ECOHS - Oxygen-dependent coproporphyrinogen-III oxidase OS=Escherichia coli O9:H4 (strain HS) GN=hemF PE=3 S... HEM6_ECOLC - Oxygen-dependent coproporphyrinogen-III oxidase OS=Escherichia coli (strain ATCC 8739 / DSM 1576 / C... HEM6_ECOBW - Oxygen-dependent coproporphyrinogen-III oxidase OS=Escherichia coli (strain K12 / MC4100 / BW2952) G...	550.0	[0..1]	[298..1]
gi\|194432098, gi... - gi\|83570659\|ref\|ZP_00922102.1\| COG0408: Coproporphyrinogen III oxidase [Shigella dysenteriae 1012], ... HEM6_ECO8A - Oxygen-dependent coproporphyrinogen-III oxidase OS=Escherichia coli O8 (strain IAI1) GN=hemF PE=3 SV... gi\|191168977, gi... - gi\|75227767\|ref\|ZP_00714496.1\| COG0408: Coproporphyrinogen III oxidase [Escherichia coli B7A], gi\|19... gi\|192958352, gi... - gi\|75237812\|ref\|ZP_00721828.1\| COG0408: Coproporphyrinogen III oxidase [Escherichia coli E110019], g... HEM6_ECO24 - Oxygen-dependent coproporphyrinogen-III oxidase OS=Escherichia coli O139:H28 (strain E24377A / ETEC)... gi\|194427271, gi... - gi\|75211406\|ref\|ZP_00711496.1\| COG0408: Coproporphyrinogen III oxidase [Escherichia coli B171], gi\|1... HEM6_SHIBS - Oxygen-dependent coproporphyrinogen-III oxidase OS=Shigella boydii serotype 4 (strain Sb227) GN=hemF... gi\|75257248, gi\|... - gi\|75257248\|ref\|ZP_00728772.1\| COG0408: Coproporphyrinogen III oxidase [Escherichia coli E22], gi\|19... HEM6_SHISS - Oxygen-dependent coproporphyrinogen-III oxidase OS=Shigella sonnei (strain Ss046) GN=hemF PE=3 SV=1	549.0	[0..1]	[298..1]
gi\|242378044, gi... - gi\|251785771\|ref\|YP_003000075.1\| hypothetical protein B21_02298 [Escherichia coli BL21], gi\|24237804... gi\|254162419, gi... - gi\|254162419\|ref\|YP_003045527.1\| coproporphyrinogen III oxidase [Escherichia coli B str. REL606], gi... gi\|253323709, gi... - gi\|254289180\|ref\|YP_003054928.1\| coproporphyrinogen III oxidase [Escherichia coli BL21(DE3)], gi\|253... gi\|194423517, gi... - gi\|83586907\|ref\|ZP_00925538.1\| COG0408: Coproporphyrinogen III oxidase [Escherichia coli 101-1], gi\|...	549.0	[0..1]	[298..1]
HEM6_SALPA - Oxygen-dependent coproporphyrinogen-III oxidase OS=Salmonella paratyphi A (strain ATCC 9150 / SARB42... HEM6_SALPA - Coproporphyrinogen-III oxidase, aerobic OS=Salmonella paratyphi A GN=hemF PE=3 SV=1 HEM6_SALPK - Oxygen-dependent coproporphyrinogen-III oxidase OS=Salmonella paratyphi A (strain AKU_12601) GN=hemF...	548.0	[0..1]	[298..1]
HEM6_SHIDS - Oxygen-dependent coproporphyrinogen-III oxidase OS=Shigella dysenteriae serotype 1 (strain Sd197) GN...	547.0	[0..1]	[298..1]
HEM6_SHIB3 - Oxygen-dependent coproporphyrinogen-III oxidase OS=Shigella boydii serotype 18 (strain CDC 3083-94 /...	546.0	[0..1]	[298..1]
gi\|214003178 - gi\|214003178\|ref\|ZP_03413913.1\| coproporphyrinogen III oxidase [Salmonella enterica subsp. enterica ... HEM6_SALTI - Oxygen-dependent coproporphyrinogen-III oxidase OS=Salmonella typhi GN=hemF PE=3 SV=1 gi\|213857596 - gi\|213857596\|ref\|ZP_03384567.1\| coproporphyrinogen III oxidase [Salmonella enterica subsp. enterica ... gi\|213027732 - gi\|213027732\|ref\|ZP_03342179.1\| coproporphyrinogen III oxidase [Salmonella enterica subsp. enterica ... gi\|29140934, gi\|... - gi\|29140934\|ref\|NP_804276.1\| coproporphyrinogen III oxidase [Salmonella enterica subsp. enterica ser... gi\|213647109 - gi\|213647109\|ref\|ZP_03377162.1\| coproporphyrinogen III oxidase [Salmonella enterica subsp. enterica ... gi\|16761369 - gi\|16761369\|ref\|NP_456986.1\| coproporphyrinogen III oxidase [Salmonella enterica subsp. enterica ser... gi\|213424311 - gi\|213424311\|ref\|ZP_03357143.1\| coproporphyrinogen III oxidase [Salmonella enterica subsp. enterica ... HEM6_SALTI - Coproporphyrinogen 3 oxidase, aerobic OS=Salmonella typhi GN=hemF PE=3 SV=1	544.0	[0..1]	[298..1]

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Predicted Domain #1

Region A:
Residues: [1-299]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKPDAHQVKQ FLLNLQDTIC QQLTAVDGAE FVEDSWQREA GGGGRSRVLR NGGVFEQAGV  60
   61 NFSHVHGEAM PASATAHRPE LAGRSFEAMG VSLVVHPHNP YVPTSHANVR FFIAEKPGAE 120
  121 PVWWFGGGFD LTPFYGFEED AIHWHRTARD LCQPFGEDVY PRYKKWCDDY FYLKHRNEQR 180
  181 GIGGLFFDDL NTPDFDHCFA FMQAVGKGYT DAYLPIVERR KAMAYGERER NFQLYRRGRY 240
  241 VEFNLVWDRG TLFGLQTGGR TESILMSMPP LVRWEYDYQP KDGSPEAALS EFIKVRDWG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	133.0
Match:	1vjuA
Description:	Hypothetical protein from Leishmania major Lmaj006828
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
coproporphyrinogen oxidase activity	5.81247465629978	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor	5.1724965213902	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors	3.24343461428814	bayes_pls_golite062009
binding	1.8297496024321	bayes_pls_golite062009
catalytic activity	1.56559069221062	bayes_pls_golite062009
protein binding	0.374996803717649	bayes_pls_golite062009
oxidoreductase activity	0.0360049460478797	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: