YRC Public Data Repository - Protein Structure Prediction

Protein:	DLD
Organism:	Homo sapiens
Length:	509 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DLD.

Description	E-value	Query Range	Subject Range
DLDH_CANLF - Dihydrolipoyl dehydrogenase, mitochondrial OS=Canis lupus familiaris GN=DLD PE=1 SV=1 gi\|55742732 - ref\|NP_001003294.1\| dihydrolipoamide: NAD+ oxidoreductase [Canis familiaris]	0.0	[1..509]	[1..509]
DLDH_CRIGR - Dihydrolipoyl dehydrogenase, mitochondrial OS=Cricetulus griseus GN=DLD PE=2 SV=1	0.0	[1..509]	[1..509]
DLDH_RAT - Dihydrolipoyl dehydrogenase, mitochondrial OS=Rattus norvegicus GN=Dld PE=1 SV=1	0.0	[1..509]	[1..509]
DLD - dihydrolipoamide dehydrogenase	0.0	[1..509]	[1..509]
gi\|114615450 - gi\|114615450\|ref\|XP_001165014.1\| PREDICTED: dihydrolipoamide dehydrogenase isoform 3 [Pan troglodyte...	0.0	[1..509]	[1..509]
gi\|76615127 - gi\|76615127\|ref\|XP_870811.1\| PREDICTED: similar to dihydrolipoamide dehydrogenase isoform 2 [Bos tau...	0.0	[1..509]	[1..509]
DLDH_PIG - Dihydrolipoyl dehydrogenase, mitochondrial OS=Sus scrofa GN=DLD PE=1 SV=1 gi\|66122 - pir\|\|DEPGLP dihydrolipoamide dehydrogenase (EC 1.8.1.4) precursor - pig	0.0	[1..509]	[1..509]

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Predicted Domain #1

Region A:
Residues: [1-509]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQSWSRVYCS LAKRGHFNRI SHGLQGLSAV PLRTYADQPI DADVTVIGSG PGGYVAAIKA  60
   61 AQLGFKTVCI EKNETLGGTC LNVGCIPSKA LLNNSHYYHM AHGKDFASRG IEMSEVRLNL 120
  121 DKMMEQKSTA VKALTGGIAH LFKQNKVVHV NGYGKITGKN QVTATKADGG TQVIDTKNIL 180
  181 IATGSEVTPF PGITIDEDTI VSSTGALSLK KVPEKMVVIG AGVIGVELGS VWQRLGADVT 240
  241 AVEFLGHVGG VGIDMEISKN FQRILQKQGF KFKLNTKVTG ATKKSDGKID VSIEAASGGK 300
  301 AEVITCDVLL VCIGRRPFTK NLGLEELGIE LDPRGRIPVN TRFQTKIPNI YAIGDVVAGP 360
  361 MLAHKAEDEG IICVEGMAGG AVHIDYNCVP SVIYTHPEVA WVGKSEEQLK EEGIEYKVGK 420
  421 FPFAANSRAK TNADTDGMVK ILGQKSTDRV LGAHILGPGA GEMVNEAALA LEYGASCEDI 480
  481 ARVCHAHPTL SEAFREANLA ASFGKSINF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	117.0
Match:	1zy8A
Description:	The crystal structure of dihydrolipoamide dehydrogenase and dihydrolipoamide dehydrogenase-binding protein (didomain) subcomplex of human pyruvate dehydrogenase complex.
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits