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View Structure Prediction Details

Protein: TAF4
Organism: Homo sapiens
Length: 1085 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TAF4.

Description E-value Query
Range
Subject
Range
gi|114682906 - gi|114682906|ref|XP_514759.2| PREDICTED: TBP-associated factor 4 [Pan troglodytes]
0.0 [590..1085] [1..496]
gi|73992671 - gi|73992671|ref|XP_534471.2| PREDICTED: similar to TBP-associated factor 4 [Canis familiaris]
0.0 [483..1085] [194..795]
TAF4 - TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa
0.0 [1..1085] [1..1083]
gi|109091400 - gi|109091400|ref|XP_001115352.1| PREDICTED: similar to TBP-associated factor 4 [Macaca mulatta]
0.0 [448..1085] [13..650]
gi|94369081, gi|... - gi|94369081|ref|XP_997720.1| PREDICTED: similar to TBP-associated factor 4 isoform 1 [Mus musculus],...
0.0 [455..1085] [1..630]

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Predicted Domain #1
Region A:
Residues: [1-108]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAGSDLLDE VFFNSEVDEK VVSDLVGSLE SQLAASAAHH HHLAPRTPEV RAAAAGALGN  60
   61 HVVSGSPAGA AGAGPAAPAE GAPGAAPEPP PAGRARPGGG GPQRPGPP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [109-334]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPRRPLVPAG PAPPAAKLRP PPEGSAGSCA PVPAAAAVAA GPEPAPAGPA KPAGPAALAA  60
   61 RAGPGPGPGP GPGPGPGPGK PAGPGAAQTL NGSAALLNSH HAAAPAVSLV NNGPAALLPL 120
  121 PKPAAPGTVI QTPPFVGAAA PPAPAAPSPP AAPAPAAPAA APPPPPPAPA TLARPPGHPA 180
  181 GPPTAAPAVP PPAAAQNGGS AGAAPAPAPA AGGPAGVSGQ PGPGAA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [335-402]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AAAPAPGVKA ESPKRVVQAA PPAAQTLAAS GPASTAASMV IGPTMQGALP SPAAVPPPAP  60
   61 GTPTGLPK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [403-574]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GAAGAVTQSL SRTPTATTSG IRATLTPTVL APRLPQPPQN PTNIQNFQLP PGMVLVRSEN  60
   61 GQLLMIPQQA LAQMQAQAHA QPQTTMAPRP ATPTSAPPVQ ISTVQAPGTP IIARQVTPTT 120
  121 IIKQVSQAQT TVQPSATLQR SPGVQPQLVL GGAAQTASLG TATAVQTGTP QR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [575-743]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TVPGATTTSS AATETMENVK KCKNFLSTLI KLASSGKQST ETAANVKELV QNLLDGKIEA  60
   61 EDFTSRLYRE LNSSPQPYLV PFLKRSLPAL RQLTPDSAAF IQQSQQQPPP PTSQATTALT 120
  121 AVVLSSSVQR TAGKTAATVT SALQPPVLSL TQPTQVGVGK QGQPTPLVI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.0
Match: 2p6vA
Description: No description for 2p6vA was found.

Predicted Domain #6
Region A:
Residues: [744-818]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QQPPKPGALI RPPQVTLTQT PMVALRQPHN RIMLTTPQQI QLNPLQPVPV VKPAVLPGTK  60
   61 ALSAVSAQAA AAQKN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [819-975]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KLKEPGGGSF RDDDDINDVA SMAGVNLSEE SARILATNSE LVGTLTRSCK DETFLLQAPL  60
   61 QRRILEIGKK HGITELHPDV VSYVSHATQQ RLQNLVEKIS ETAQQKNFSY KDDDRYEQAS 120
  121 DVRAQLKFFE QLDQIEKQRK DEQEREILMR AAKSRSR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 33.69897
Match: 1h3oA
Description: TAF(II)-135, (TAF(II)-130, hTAF4), histone fold domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.581886805340955 bayes_pls_golite062009

Predicted Domain #8
Region A:
Residues: [976-1085]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QEDPEQLRLK QKAKEMQQQE LAQMRQRDAN LTALAAIGPR KKRKVDCPGP GSGAEGSGPG  60
   61 SVVPGSSGVG TPRQFTRQRI TRVNLRDLIF CLENERETSH SLLLYKAFLK 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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