YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|11353834
Organism:	Neisseria meningitidis
Length:	245 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|11353834.

Description	E-value	Query Range	Subject Range
gi\|38488593 - gi\|38488593\|dbj\|BAD02311.1\| peroxiredoxin like protein [Actinobacillus actinomycetemcomitans]	201.0	[0..3]	[244..12]
gi\|145642264, gi... - gi\|145642264\|ref\|ZP_01797829.1\| DNA-binding transcriptional regulator OxyR [Haemophilus influenzae R... gi\|145638519, gi... - gi\|145638519\|ref\|ZP_01794128.1\| hypothetical protein CGSHiII_07391 [Haemophilus influenzae PittII], ... gi\|145642264, gi... - gi\|145642264\|ref\|ZP_01797829.1\| DNA-binding transcriptional regulator OxyR [Haemophilus influenzae R... gi\|144979425, gi... - gi\|145628955\|ref\|ZP_01784755.1\| DNA-binding transcriptional regulator OxyR [Haemophilus influenzae 2... gi\|42630851 - gi\|42630851\|ref\|ZP_00156390.1\| COG0678: Peroxiredoxin [Haemophilus influenzae R2866] gi\|68057371, gi\|... - gi\|68249172\|ref\|YP_248284.1\| peroxiredoxin/glutaredoxin [Haemophilus influenzae 86-028NP], gi\|680573...	201.0	[0..3]	[242..1]
PRX5_HAEIN, Y572... - (P44758) Protein HI0572, Hybrid peroxiredoxin hyPrx5 OS=Haemophilus influenzae GN=HI_0572 PE=1 SV=1 gi\|260581018\|ref... - peroxiredoxin hybrid Prx5 [Haemophilus influenzae RdAW] PRX5_HAEIN - Hybrid peroxiredoxin hyPrx5 OS=Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) GN...	200.0	[0..3]	[242..1]
gi\|145268872, gi... - gi\|145637932\|ref\|ZP_01793574.1\| DNA-binding transcriptional regulator OxyR [Haemophilus influenzae P... gi\|144985841, gi... - gi\|145633472\|ref\|ZP_01789201.1\| hypothetical protein CGSHi3655_05114 [Haemophilus influenzae 3655], ... gi\|42630019 - gi\|42630019\|ref\|ZP_00155564.1\| COG0678: Peroxiredoxin [Haemophilus influenzae R2846]	200.0	[0..3]	[242..1]
gi\|32034501 - gi\|32034501\|ref\|ZP_00134673.1\| COG0678: Peroxiredoxin [Actinobacillus pleuropneumoniae serovar 1 str...	198.0	[0..1]	[244..1]
gi\|46156414, gi\|... - gi\|46156414\|ref\|ZP_00132875.2\| COG0678: Peroxiredoxin [Haemophilus somnus 2336], gi\|170718219\|ref\|YP... gi\|23467482 - gi\|23467482\|ref\|ZP_00123063.1\| COG0678: Peroxiredoxin [Haemophilus somnus 129PT]	198.0	[0..1]	[242..1]
gi\|239998839 - gi\|239998839\|ref\|ZP_04718763.1\| Peroxiredoxin 2 family protein/glutaredoxin [Neisseria gonorrhoeae 3... gi\|240112765 - gi\|240112765\|ref\|ZP_04727255.1\| Peroxiredoxin 2 family protein/glutaredoxin [Neisseria gonorrhoeae M... gi\|260440673\|ref... - peroxiredoxin 2 family protein/glutaredoxin [Neisseria gonorrhoeae DGI2], Peroxiredoxin 2 family pro... gi\|240080871 - gi\|240080871\|ref\|ZP_04725414.1\| Peroxiredoxin 2 family protein/glutaredoxin [Neisseria gonorrhoeae F... gi\|240016682 - gi\|240016682\|ref\|ZP_04723222.1\| Peroxiredoxin 2 family protein/glutaredoxin [Neisseria gonorrhoeae F... gi\|240014246 - gi\|240014246\|ref\|ZP_04721159.1\| Peroxiredoxin 2 family protein/glutaredoxin [Neisseria gonorrhoeae D... gi\|240123366 - gi\|240123366\|ref\|ZP_04736322.1\| Peroxiredoxin 2 family protein/glutaredoxin [Neisseria gonorrhoeae P... gi\|193933729, gi... - gi\|194098439\|ref\|YP_002001498.1\| Peroxiredoxin 2 family protein/glutaredoxin [Neisseria gonorrhoeae ... gi\|240121809 - gi\|240121809\|ref\|ZP_04734771.1\| Peroxiredoxin 2 family protein/glutaredoxin [Neisseria gonorrhoeae P... gi\|240117811 - gi\|240117811\|ref\|ZP_04731873.1\| Peroxiredoxin 2 family protein/glutaredoxin [Neisseria gonorrhoeae P... gi\|240115515 - gi\|240115515\|ref\|ZP_04729577.1\| Peroxiredoxin 2 family protein/glutaredoxin [Neisseria gonorrhoeae P... gi\|254493624, gi... - gi\|254493624\|ref\|ZP_05106795.1\| redoxin [Neisseria gonorrhoeae 1291], gi\|226512664\|gb\|EEH62009.1\| re... gi\|240125614 - gi\|240125614\|ref\|ZP_04738500.1\| Peroxiredoxin 2 family protein/glutaredoxin [Neisseria gonorrhoeae S... gi\|59718217, gi\|... - gi\|59801322\|ref\|YP_208034.1\| putative peroxiredoxin family protein/glutaredoxin [Neisseria gonorrhoe...	198.0	[0..1]	[245..1]
gi\|33151875, gi\|... - gi\|33151875\|ref\|NP_873228.1\| putative peroxiredoxin/glutaredoxin family protein [Haemophilus ducreyi...	198.0	[0..1]	[244..1]
gi\|91188685, gi\|... - gi\|91227291\|ref\|ZP_01261716.1\| peroxiredoxin family protein/glutaredoxin [Vibrio alginolyticus 12G01...	197.0	[0..6]	[242..5]
gi\|186893469, gi... - gi\|186893469\|ref\|YP_001870581.1\| glutaredoxin family protein [Yersinia pseudotuberculosis PB1/+], gi... gi\|170026287, gi... - gi\|170026287\|ref\|YP_001722792.1\| glutaredoxin family protein [Yersinia pseudotuberculosis YPIII], gi... gi\|229695978, gi... - gi\|229839612\|ref\|ZP_04459771.1\| putative peroxiredoxin/glutaredoxin family protein [Yersinia pestis ... gi\|229691036, gi... - gi\|229841697\|ref\|ZP_04461853.1\| putative peroxiredoxin/glutaredoxin family protein [Yersinia pestis ... gi\|229896701, gi... - gi\|229896701\|ref\|ZP_04511866.1\| putative peroxiredoxin/glutaredoxin family protein [Yersinia pestis ... Q66G63\|Q66G63_YERPS - Putative peroxiredoxin/glutaredoxin family protein - Yersinia pseudotuberculosis gi\|165919612, gi... - gi\|165928382\|ref\|ZP_02224214.1\| hybrid peroxiredoxin hyPrx5 [Yersinia pestis biovar Orientalis str. ... gi\|166213757, gi... - gi\|166213757\|ref\|ZP_02239792.1\| hybrid peroxiredoxin hyPrx5 [Yersinia pestis biovar Antiqua str. B42... gi\|165991426, gi... - gi\|166009504\|ref\|ZP_02230402.1\| hybrid peroxiredoxin hyPrx5 [Yersinia pestis biovar Antiqua str. E19... gi\|167420978, gi... - gi\|167420978\|ref\|ZP_02312731.1\| hybrid peroxiredoxin hyPrx5 [Yersinia pestis biovar Orientalis str. ... gi\|167401355, gi... - gi\|167401355\|ref\|ZP_02306855.1\| hybrid peroxiredoxin hyPrx5 [Yersinia pestis biovar Antiqua str. UG0... gi\|167467890 - gi\|167467890\|ref\|ZP_02332594.1\| hybrid peroxiredoxin hyPrx5 [Yersinia pestis FV-1] gi\|167425931, gi... - gi\|167425931\|ref\|ZP_02317684.1\| hybrid peroxiredoxin hyPrx5 [Yersinia pestis biovar Mediaevalis str.... gi\|218930916, gi... - gi\|218930916\|ref\|YP_002348791.1\| putative peroxiredoxin/glutaredoxin family protein [Yersinia pestis... gi\|165915226, gi... - gi\|89102385\|ref\|ZP_01175023.1\| COG0678: Peroxiredoxin [Yersinia pestis biovar Orientalis str. IP275]... gi\|108806104, gi... - gi\|108806104\|ref\|YP_650020.1\| putative peroxiredoxin/glutaredoxin family protein [Yersinia pestis An... gi\|108810217, gi... - gi\|229904749\|ref\|ZP_04519860.1\| putative peroxiredoxin/glutaredoxin family protein [Yersinia pestis ... gi\|270488732\|ref... - glutaredoxin [Yersinia pestis KIM D27] gi\|149290529, gi... - gi\|150261121\|ref\|ZP_01917849.1\| putative peroxiredoxin/glutaredoxin family protein [Yersinia pestis ... gi\|145212471, gi... - gi\|145600775\|ref\|YP_001164851.1\| peroxiredoxin/glutaredoxin family protein [Yersinia pestis Pestoide... gi\|21957000, gi\|... - gi\|22124236\|ref\|NP_667659.1\| peroxiredoxin family protein [Yersinia pestis KIM], gi\|21957000\|gb\|AAM8... gi\|25347426 - pir\|\|AB0477 probable peroxiredoxin/glutaredoxin family protein YPO3916 [imported] - Yersinia pestis ... gi\|51587759, gi\|... - gi\|51594477\|ref\|YP_068668.1\| putative peroxiredoxin/glutaredoxin family protein [Yersinia pseudotube... gi\|45437753, gi\|... - gi\|45442886\|ref\|NP_994425.1\| putative peroxiredoxin/glutaredoxin family protein [Yersinia pestis bio... gi\|77633924, gi\|... - gi\|77633924\|ref\|ZP_00796037.1\| COG0678: Peroxiredoxin [Yersinia pestis Angola], gi\|162419256\|ref\|YP_... gi\|152960856, gi... - gi\|77630801\|ref\|ZP_00793387.1\| COG0678: Peroxiredoxin [Yersinia pseudotuberculosis IP 31758], gi\|153... gi\|294505566\|ref... - putative peroxiredoxin/glutaredoxin family protein [Yersinia pestis Z176003]	196.0	[0..6]	[242..5]

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Predicted Domain #1

Region A:
Residues: [1-245]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALQDRTGQK VPSVVFRTRV GDTWKDVSTD DLFKGKKVVV FSLPGAFTPT CSSSHLPRYN  60
   61 ELFGAFKENG VDAIYCVSVN DTFVMNAWAA EEESDNIYMI PDGNGEFTEG MGMLVGKEDL 120
  121 GFGKRSWRYS MLVNDGVVEK MFIEPEEPGD PFKVSDADTM LQFVAPDWKA QESVAIFTKP 180
  181 GCQFCAKAKQ ALQDKGLSYE EIVLGKDATV TSVRAITGKM TAPQVFIGGK YIGGSEDLEA 240
  241 YLAKN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	51.522879
Match:	1nm3A
Description:	C-terminal, Grx domain of Hybrid-Prx5; N-terminal, Prx domain of Hybrid-Prx5
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
antioxidant activity	2.76704361987669	bayes_pls_golite062009
peroxidase activity	2.4535286431475	bayes_pls_golite062009
oxidoreductase activity, acting on peroxide as acceptor	2.4535286431475	bayes_pls_golite062009
peroxiredoxin activity	1.60801416784303	bayes_pls_golite062009
thioredoxin peroxidase activity	1.48148817403114	bayes_pls_golite062009
glutathione peroxidase activity	1.40767929314355	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors	1.17905334170166	bayes_pls_golite062009
disulfide oxidoreductase activity	0.691543699484554	bayes_pls_golite062009
catalytic activity	0.672192331361968	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: