YRC Public Data Repository - Protein Structure Prediction

Protein:	NADC_ECOLI
Organism:	Escherichia coli
Length:	297 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NADC_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|62178714, gi\|... - gi\|62178714\|ref\|YP_215131.1\| nicotinate-nucleotide pyrophosphorylase [Salmonella enterica subsp. ent... gi\|7688345\|emb\|C... - NadC protein [Salmonella typhimurium] gi\|7688345 - gi\|7688345\|emb\|CAB89834.1\| NadC protein [Salmonella typhimurium]	336.0	[0..1]	[296..15]
gi\|238911203 - gi\|238911203\|ref\|ZP_04655040.1\| quinolinate phosphoribosyltransferase [Salmonella enterica subsp. en... gi\|56126676, gi\|... - gi\|56412419\|ref\|YP_149494.1\| quinolinate phosphoribosyltransferase [Salmonella enterica subsp. enter... gi\|194458766, gi... - gi\|194472402\|ref\|ZP_03078386.1\| nicotinate-nucleotide diphosphorylase [Salmonella enterica subsp. en... gi\|168230426, gi... - gi\|205334949\|gb\|EDZ21713.1\| nicotinate-nucleotide diphosphorylase [Salmonella enterica subsp. enteri...	335.0	[0..1]	[297..1]
gi\|91228624, gi\|... - gi\|91228624\|ref\|ZP_01262541.1\| nicotinate-nucleotide pyrophosphorylase [Vibrio alginolyticus 12G01],...	334.0	[0..4]	[297..3]
lcl\|NC_016856.1_... - [gene=nadC] [protein=quinolinate phosphoribosyltransferase] [protein_id=YP_005235806.1] [location=co... NADC_SALTY - Nicotinate-nucleotide pyrophosphorylase [carboxylating] OS=Salmonella typhimurium (strain LT2 / SGSC... gi\|224466517, gi... - gi\|224581990\|ref\|YP_002635788.1\| nicotinate-nucleotide pyrophosphorylase [Salmonella enterica subsp.... NADC_SALTY - Nicotinate-nucleotide pyrophosphorylase [carboxylating] OS=Salmonella typhimurium GN=nadC PE=1 SV=3 gi\|194406281, gi... - gi\|194447977\|ref\|YP_002044115.1\| quinolinate phosphoribosyltransferase [Salmonella enterica subsp. e... gi\|197263332, gi... - gi\|197263332\|ref\|ZP_03163406.1\| nicotinate-nucleotide diphosphorylase [Salmonella enterica subsp. en... gi\|197937000, gi... - gi\|198242484\|ref\|YP_002214098.1\| nicotinate-nucleotide diphosphorylase [Salmonella enterica subsp. e... gi\|200388062, gi... - gi\|200388062\|ref\|ZP_03214674.1\| nicotinate-nucleotide diphosphorylase [Salmonella enterica subsp. en... gi\|167990020, gi... - gi\|205331315\|gb\|EDZ18079.1\| nicotinate-nucleotide diphosphorylase [Salmonella enterica subsp. enteri... gi\|205337522, gi... - gi\|205337522\|gb\|EDZ24286.1\| nicotinate-nucleotide diphosphorylase [Salmonella enterica subsp. enteri... gi\|205347469, gi... - gi\|205347469\|gb\|EDZ34100.1\| nicotinate-nucleotide diphosphorylase [Salmonella enterica subsp. enteri... gi\|194444228, gi... - gi\|194444228\|ref\|YP_002039377.1\| nicotinate-nucleotide diphosphorylase [Salmonella enterica subsp. e... NADC_SALTY - Nicotinate-nucleotide pyrophosphorylase [carboxylating] OS=Salmonella typhimurium GN=nadC PE=1 SV=3 gi\|162139623 - gi\|162139623\|ref\|YP_215131.2\| quinolinate phosphoribosyltransferase [Salmonella enterica subsp. ente...	334.0	[0..1]	[296..1]
gi\|29140692, gi\|... - gi\|29140692\|ref\|NP_804034.1\| quinolinate phosphoribosyltransferase [Salmonella enterica subsp. enter... gi\|16759142 - gi\|16759142\|ref\|NP_454759.1\| quinolinate phosphoribosyltransferase [Salmonella enterica subsp. enter... gi\|213857636 - gi\|213857636\|ref\|ZP_03384607.1\| quinolinate phosphoribosyltransferase [Salmonella enterica subsp. en... gi\|213999304 - gi\|213999304\|ref\|ZP_03410039.1\| quinolinate phosphoribosyltransferase [Salmonella enterica subsp. en... gi\|213052267 - gi\|213052267\|ref\|ZP_03345145.1\| quinolinate phosphoribosyltransferase [Salmonella enterica subsp. en... gi\|16501432, gi\|... - gi\|25324575\|pir\|\|AH0520 nicotinate-nucleotide pyrophosphorylase [imported] - Salmonella enterica sub... gi\|213582390 - gi\|213582390\|ref\|ZP_03364216.1\| quinolinate phosphoribosyltransferase [Salmonella enterica subsp. en... gi\|213618717 - gi\|213618717\|ref\|ZP_03372543.1\| quinolinate phosphoribosyltransferase [Salmonella enterica subsp. en... gi\|213648172 - gi\|213648172\|ref\|ZP_03378225.1\| quinolinate phosphoribosyltransferase [Salmonella enterica subsp. en...	333.0	[0..1]	[296..1]
gi\|90438546, gi\|... - gi\|90580244\|ref\|ZP_01236051.1\| nicotinate-nucleotide pyrophosphorylase [Vibrio angustum S14], gi\|904...	332.0	[0..6]	[297..5]
gi\|1941992, gi\|1... - gi\|1941992\|pdb\|1QAP\|B Chain B, Quinolinic Acid Phosphoribosyltransferase With Bound Quinolinic Acid,... gi\|1941991\|pdb\|1... - Chain A, Quinolinic Acid Phosphoribosyltransferase With Bound Quinolinic Acid, Chain B, Quinolinic A...	332.0	[0..2]	[296..1]
gi\|37199711, gi\|... - gi\|37680961\|ref\|NP_935570.1\| quinolinate phosphoribosyltransferase [Vibrio vulnificus YJ016], gi\|371...	331.0	[0..4]	[297..15]
gi\|89050087, gi\|... - gi\|89074151\|ref\|ZP_01160650.1\| nicotinate-nucleotide pyrophosphorylase [Photobacterium sp. SKA34], g...	331.0	[0..6]	[297..5]
gi\|16930777 - gi\|16930777\|gb\|AAL32048.1\|AF439854_1 NadC [Vibrio vulnificus]	330.0	[0..4]	[297..3]

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Predicted Domain #1

Region A:
Residues: [1-297]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPPRRYNPDT RRDELLERIN LDIPGAVAQA LREDLGGTVD ANNDITAKLL PENSRSHATV  60
   61 ITRENGVFCG KRWVEEVFIQ LAGDDVTIIW HVDDGDVINA NQSLFELEGP SRVLLTGERT 120
  121 ALNFVQTLSG VASKVRHYVE LLEGTNTQLL DTRKTLPGLR SALKYAVLCG GGANHRLGLS 180
  181 DAFLIKENHI IASGSVRQAV EKASWLHPDA PVEVEVENLE ELDEALKAGA DIIMLDNFET 240
  241 EQMREAVKRT NGKALLEVSG NVTDKTLREF AETGVDFISV GALTKHVQAL DLSMRFR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	91.045757
Match:	1qapA
Description:	Quinolinic acid phosphoribosyltransferase (Nicotinate-nucleotide pyrophosphorylase, NadC), C-terminal domain; Quinolinic acid phosphoribosyltransferase (Nicotinate-nucleotide pyrophosphorylase, NadC), N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
nicotinate phosphoribosyltransferase activity	3.4096751090496	bayes_pls_golite062009
nicotinate-nucleotide diphosphorylase (carboxylating) activity	3.12788282156037	bayes_pls_golite062009
binding	1.58263447797054	bayes_pls_golite062009
catalytic activity	0.60409960326459	bayes_pls_golite062009
protein binding	0.502035039039958	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: