YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|48825284
Organism:	Enterococcus faecium
Length:	275 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|48825284.

Description	E-value	Query Range	Subject Range
gi\|147676555, gi... - gi\|98661989\|dbj\|GAA01057.1\| unnamed protein product [Pelotomaculum thermopropionicum SI], gi\|1476765...	450.0	[0..2]	[275..5]
gi\|88946455, gi\|... - gi\|88946455\|ref\|ZP_01149533.1\| Ketopantoate hydroxymethyltransferase [Desulfotomaculum reducens MI-1...	447.0	[0..2]	[275..4]
gi\|27262460 - gi\|27262460\|gb\|AAN87511.1\| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Heliobacillus mobilis]	446.0	[0..2]	[275..4]
PANB_CLOB8 - 3-methyl-2-oxobutanoate hydroxymethyltransferase OS=Clostridium beijerinckii (strain ATCC 51743 / NC...	440.0	[0..1]	[275..1]
gi\|85859368, gi\|... - gi\|85859368\|ref\|YP_461570.1\| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Syntrophus aciditroph...	436.0	[0..2]	[264..15]
PANB_CARHZ - 3-methyl-2-oxobutanoate hydroxymethyltransferase OS=Carboxydothermus hydrogenoformans (strain ATCC B...	436.0	[0..2]	[275..3]
gi\|255100541 - gi\|255100541\|ref\|ZP_05329518.1\| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Clostridium diffic... PANB_PEPD6 - 3-methyl-2-oxobutanoate hydroxymethyltransferase OS=Peptoclostridium difficile (strain 630) GN=panB ...	436.0	[0..1]	[275..1]
PANB_CLOAB - 3-methyl-2-oxobutanoate hydroxymethyltransferase OS=Clostridium acetobutylicum (strain ATCC 824 / DS... PANB_CLOAB - 3-methyl-2-oxobutanoate hydroxymethyltransferase OS=Clostridium acetobutylicum GN=panB PE=3 SV=1	434.0	[0..1]	[274..1]
gi\|255314196 - gi\|255314196\|ref\|ZP_05355779.1\| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Clostridium diffic... gi\|255516875 - gi\|255516875\|ref\|ZP_05384551.1\| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Clostridium diffic... gi\|255649976 - gi\|255649976\|ref\|ZP_05396878.1\| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Clostridium diffic... gi\|119635940, gi... - gi\|90575017\|ref\|ZP_01231505.1\| hypothetical protein CdifQ_02001577 [Clostridium difficile QCD-32g58]... gi\|254975069 - gi\|254975069\|ref\|ZP_05271541.1\| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Clostridium diffic... gi\|255092458 - gi\|255092458\|ref\|ZP_05321936.1\| 3-methyl-2-oxobutanoate hydroxymethyltransferase [Clostridium diffic...	434.0	[0..1]	[275..1]

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Predicted Domain #1

Region A:
Residues: [1-275]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKNTAVTFKE SKLRNEKLTM LTAYDYSTAK IIDEAGINGI LVGDSLGMVC LGHEDTLSVT  60
   61 MEDMIHHTRA VTRGAKNTLV VADMPFMSYQ TSVYDSVVNA GRLIKEGRAQ VVKLEGGIEV 120
  121 CDKIEAIVKA SIPVMAHIGL TPQSVNAFGG FKVQGKDKEA AKELIRAAKA VEKAGAFAVV 180
  181 LECVPTKLAE LISKEISIPT IGIGAGAGCD GQILVYQDML GMYSDFTPKF VKKYANLSEE 240
  241 MNKAFTKYIE EVKDGVFPGP EHGFKISDDV LEKLY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	110.0
Match:	1m3uA
Description:	Ketopantoate hydroxymethyltransferase PanB
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
3-methyl-2-oxobutanoate hydroxymethyltransferase activity	4.08693637310631	bayes_pls_golite062009
catalytic activity	2.59838799615646	bayes_pls_golite062009
hydroxymethyl-, formyl- and related transferase activity	2.05689968523792	bayes_pls_golite062009
transferase activity	1.07154136609184	bayes_pls_golite062009
glycine hydroxymethyltransferase activity	0.646649320021871	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.366715189574293	bayes_pls_golite062009
oxo-acid-lyase activity	0.0960362356555544	bayes_pls_golite062009
carbon-carbon lyase activity	0.0846611486307003	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: