YRC Public Data Repository - Protein Structure Prediction

Protein:	META_ECOLI
Organism:	Escherichia coli
Length:	309 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for META_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|41998 - gi\|41998\|emb\|CAA32654.1\| unnamed protein product [Escherichia coli]	348.0	[0..1]	[309..1]
META_VIBVY - Homoserine O-succinyltransferase OS=Vibrio vulnificus (strain YJ016) GN=metA PE=3 SV=1	347.0	[0..1]	[306..1]
META_VIBVU - Homoserine O-succinyltransferase OS=Vibrio vulnificus (strain CMCP6) GN=metA PE=3 SV=1 META_VIBVU - Homoserine O-succinyltransferase OS=Vibrio vulnificus GN=metA PE=3 SV=1	347.0	[0..1]	[306..1]
gi\|30064710, gi\|... - gi\|30064710\|ref\|NP_838881.1\| homoserine O-succinyltransferase [Shigella flexneri 2a str. 2457T], gi\|... META_SHIF8 - Homoserine O-succinyltransferase OS=Shigella flexneri serotype 5b (strain 8401) GN=metA PE=3 SV=1	347.0	[0..1]	[309..1]
META_SHISS - Homoserine O-succinyltransferase OS=Shigella sonnei (strain Ss046) GN=metA PE=3 SV=1	346.0	[0..1]	[309..1]
META_ECOL6 - Homoserine O-succinyltransferase OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) GN=m... META_ECOL5 - Homoserine O-succinyltransferase OS=Escherichia coli O6:K15:H31 (strain 536 / UPEC) GN=metA PE=3 SV=... META_ECOUT - Homoserine O-succinyltransferase OS=Escherichia coli (strain UTI89 / UPEC) GN=metA PE=3 SV=1 gi\|226901471, gi... - gi\|237703559\|ref\|ZP_04534040.1\| homoserine O-succinyltransferase MetA [Escherichia sp. 3_2_53FAA], g... gi\|227836132, gi... - gi\|227886991\|ref\|ZP_04004796.1\| homoserine O-succinyltransferase [Escherichia coli 83972], gi\|227836... sp\|B7UPG4\|META_ECO27 - Homoserine O-succinyltransferase OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=metA PE=3 S... META_ECO27 - Homoserine O-succinyltransferase OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=metA PE=3 S... META_ECO45 - Homoserine O-succinyltransferase OS=Escherichia coli O45:K1 (strain S88 / ExPEC) GN=metA PE=3 SV=1 META_ECOK1 - Homoserine O-succinyltransferase OS=Escherichia coli O1:K1 / APEC GN=metA PE=3 SV=1 META_ECO81 - Homoserine O-succinyltransferase OS=Escherichia coli O81 (strain ED1a) GN=metA PE=3 SV=1 META_ECOL6 - Homoserine O-succinyltransferase OS=Escherichia coli O6 GN=metA PE=3 SV=3 gi\|190907698, gi... - gi\|75241039\|ref\|ZP_00724913.1\| COG1897: Homoserine trans-succinylase [Escherichia coli F11], gi\|1911...	346.0	[0..1]	[309..1]
gi\|217325123, gi... - gi\|217325123\|ref\|ZP_03441207.1\| homoserine O-succinyltransferase [Escherichia coli O157:H7 str. TW14... META_ECO7I - Homoserine O-succinyltransferase OS=Escherichia coli O7:K1 (strain IAI39 / ExPEC) GN=metA PE=3 SV=1 gi\|208807755, gi... - gi\|208807755\|ref\|ZP_03250092.1\| homoserine O-succinyltransferase [Escherichia coli O157:H7 str. EC42... gi\|208735645, gi... - gi\|208814368\|ref\|ZP_03255697.1\| homoserine O-succinyltransferase [Escherichia coli O157:H7 str. EC40... gi\|208821508, gi... - gi\|208821508\|ref\|ZP_03261828.1\| homoserine O-succinyltransferase [Escherichia coli O157:H7 str. EC40... META_ECO5E - Homoserine O-succinyltransferase OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) GN=metA PE=3 SV=... gi\|189374833, gi... - gi\|189374833\|gb\|EDU93249.1\| homoserine O-succinyltransferase [Escherichia coli O157:H7 str. EC869], ... gi\|168798356, gi... - gi\|189379183\|gb\|EDU97599.1\| homoserine O-succinyltransferase [Escherichia coli O157:H7 str. EC508], ... META_ECOSM - Homoserine O-succinyltransferase OS=Escherichia coli (strain SMS-3-5 / SECEC) GN=metA PE=3 SV=1 gi\|195935771 - gi\|195935771\|ref\|ZP_03081153.1\| homoserine O-succinyltransferase [Escherichia coli O157:H7 str. EC40... gi\|168760847, gi... - gi\|189368505\|gb\|EDU86921.1\| homoserine O-succinyltransferase [Escherichia coli O157:H7 str. EC4501],... gi\|189364088, gi... - gi\|189364088\|gb\|EDU82507.1\| homoserine O-succinyltransferase [Escherichia coli O157:H7 str. EC4486],... gi\|168774339, gi... - gi\|187769979\|gb\|EDU33823.1\| homoserine O-succinyltransferase [Escherichia coli O157:H7 str. EC4196],... gi\|254595406, gi... - gi\|254796006\|ref\|YP_003080843.1\| homoserine transsuccinylase [Escherichia coli O157:H7 str. TW14359]... gi\|189001797, gi... - gi\|189001797\|gb\|EDU70783.1\| homoserine O-succinyltransferase [Escherichia coli O157:H7 str. EC4076],... META_ECO57 - Homoserine O-succinyltransferase OS=Escherichia coli O157:H7 GN=metA PE=3 SV=2 gi\|168750868, gi... - gi\|188015019\|gb\|EDU53141.1\| homoserine O-succinyltransferase [Escherichia coli O157:H7 str. EC4113],... gi\|209751606, gi... - pir\|\|A86093 homoserine transsuccinylase [imported] - Escherichia coli (strain O157:H7, substrain ED... gi\|189357564, gi... - gi\|189357564\|gb\|EDU75983.1\| homoserine O-succinyltransferase [Escherichia coli O157:H7 str. EC4401],... gi\|12518943, gi\|... - gi\|15804599\|ref\|NP_290640.1\| homoserine O-succinyltransferase [Escherichia coli O157:H7 EDL933], gi\|... gi\|15834185, gi\|... - gi\|15834185\|ref\|NP_312958.1\| homoserine O-succinyltransferase [Escherichia coli O157:H7 str. Sakai],...	346.0	[0..1]	[309..1]
META_SHIB3 - Homoserine O-succinyltransferase OS=Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) GN=metA... META_SHIBS - Homoserine O-succinyltransferase OS=Shigella boydii serotype 4 (strain Sb227) GN=metA PE=3 SV=1 META_ECOLU - Homoserine O-succinyltransferase OS=Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC) GN=metA PE=...	346.0	[0..1]	[309..1]
gi\|238782894, gi... - gi\|77957521\|ref\|ZP_00821575.1\| COG1897: Homoserine trans-succinylase [Yersinia bercovieri ATCC 43970...	345.0	[0..1]	[309..1]
gi\|238789942, gi... - gi\|77972830\|ref\|ZP_00828387.1\| COG1897: Homoserine trans-succinylase [Yersinia frederiksenii ATCC 33...	345.0	[0..1]	[309..1]

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Predicted Domain #1

Region A:
Residues: [1-309]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPIRVPDELP AVNFLREENV FVMTTSRASG QEIRPLKVLI LNLMPKKIET ENQFLRLLSN  60
   61 SPLQVDIQLL RIDSRESRNT PAEHLNNFYC NFEDIQDQNF DGLIVTGAPL GLVEFNDVAY 120
  121 WPQIKQVLEW SKDHVTSTLF VCWAVQAALN ILYGIPKQTR TEKLSGVYEH HILHPHALLT 180
  181 RGFDDSFLAP HSRYADFPAA LIRDYTDLEI LAETEEGDAY LFASKDKRIA FVTGHPEYDA 240
  241 QTLAQEFFRD VEAGLDPDVP YNYFPHNDPQ NTPRASWRSH GNLLFTNWLN YYVYQITPYD 300
  301 LRHMNPTLD

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	89.69897
Match:	2ghrA
Description:	No description for 2ghrA was found.

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.67435536171189	bayes_pls_golite062009
homoserine O-succinyltransferase activity	1.30145766753842	bayes_pls_golite062009
O-succinyltransferase activity	1.30145766753842	bayes_pls_golite062009
ligase activity	1.25010133890527	bayes_pls_golite062009
imidazoleglycerol-phosphate synthase activity	0.52616972602552	bayes_pls_golite062009
anthranilate synthase activity	0.21391494060026	bayes_pls_golite062009
O-acyltransferase activity	0.20956639361114	bayes_pls_golite062009
carbon-nitrogen ligase activity, with glutamine as amido-N-donor	0.113939560975652	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	0.100283432019111	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: